author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03282295 chr6:17418420 6 17418420 CAP2 Open sea -0.00069 0.000075 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18876602 chr6:17393472 6 17393472 CAP2 Open sea -0.017 0.0019 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21183536 chr6:17393563 6 17393563 CAP2 Open sea 0.0015 0.00016 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0029 0.00015 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22997906 chr6:17556830 6 17556830 CAP2 Open sea -0.003 0.00034 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea -0.0041 0.0003 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25416270 chr6:17505703 6 17505703 CAP2 Open sea -0.0011 0.00012 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18876602 chr6:17393472 6 17393472 CAP2 Open sea 0.45961 0.00568 8.2e-151 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02934347 chr6:17393628 6 17393628 CAP2 Open sea 0.18406 0.00258 1.4999999999999999e-140 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11276986 chr6:17393616 6 17393616 CAP2 Open sea 0.18983 0.00277 2.1e-137 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg23087150 chr6:17393647 6 17393647 CAP2 Open sea 0.14496 0.00212 4.1e-137 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21183536 chr6:17393563 6 17393563 CAP2 Open sea 0.14113 0.00258 1.5e-119 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg24017912 chr6:17393521 6 17393521 CAP2 Open sea 0.16656 0.00311 8.3e-118 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg23013864 chr6:17393396 6 17393396 CAP2 Open sea 0.22654 0.00598 2.3e-91 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.14017 0.00817506 2.9044999999999998e-65 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.28651 0.01124 1.1e-63 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 3.3 0.204 2.6000000000000004e-57 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22997906 chr6:17556830 6 17556830 CAP2 Open sea 0.11072 0.00528 1.3e-51 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0021 None 5.1e-51 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.119382 0.00819752 1.037213e-47 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.392235 0.0277829 5.091569e-45 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.16878 0.00951 1.9999999999999998e-42 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06573088 chr6:17492721 6 17492721 CAP2 Open sea -0.04126 0.00247 2.7999999999999998e-39 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18449728 chr6:17393822 6 17393822 CAP2 Open sea 0.00024 None 1.6000000000000001e-38 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.120615 0.00945212 4.284151e-37 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg16709403 chr6:17470162 6 17470162 CAP2 Open sea 0.06354 0.00418 7.8e-35 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06682978 chr6:17394417 6 17394417 CAP2 Open sea 0.01978 0.00131 1.1e-34 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.116197 0.00948944 2.633844e-34 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.113303 0.00960269 5.505687e-32 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14488952 chr6:17394312 6 17394312 CAP2 Open sea 0.01623 0.00117 8.3e-31 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg05374569 chr6:17413083 6 17413083 CAP2 Open sea -0.03483 0.00254 2.7000000000000002e-30 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.331159 0.0290595 5.53987e-30 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg03282295 chr6:17418420 6 17418420 CAP2 Open sea - - 6.15e-30 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.113307 0.00994872 6.333773e-30 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg06573088 chr6:17492721 6 17492721 CAP2 Open sea 1.88582 0.11234 5.0400000000000004e-29 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0914822 0.00822195 1.2126760000000001e-28 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.09107 0.00822226 2.125025e-28 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.0902459 0.00822288 6.473889e-28 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.300012 0.0287304 1.891299e-25 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0959066 0.00964619 3.2225850000000004e-23 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg18449728 chr6:17393822 6 17393822 CAP2 Open sea 0.01478 0.0013 3.5e-23 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.081567 0.00822906 4.3600640000000005e-23 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21597596 chr6:17393825 6 17393825 CAP2 Open sea 0.0155 0.0014 2.3000000000000003e-22 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0929956 0.00963392 5.55296e-22 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0787574 0.00823093 1.254638e-21 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0908779 0.00963644 4.675727e-21 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea 0.0764173 0.00823243 1.8838179999999998e-20 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0742326 0.00823379 2.1963669999999998e-19 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0853678 0.00953605 3.8999309999999997e-19 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.112007 0.0125231 4.1921549999999995e-19 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea 0.0733307 0.00823434 5.930968999999999e-19 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.317943 0.0359806 1.080553e-18 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0727154 0.00823471 1.160023e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21597596 chr6:17393825 6 17393825 CAP2 Open sea 0.00046 None 1.6e-18 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0810245 0.00923885 1.981148e-18 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.251041 0.0288236 3.321443e-18 None 39706196_Hannah-M.-Smith_body_fat_discovery Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg22997906 chr6:17556830 6 17556830 CAP2 Open sea -4.099841 0.4757 6.83e-18 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.070979 0.00823575 7.474696e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0816799 0.00964252 2.666406e-17 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0695893 0.00823656 3.215918e-17 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0688078 0.008237 7.215331000000001e-17 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0835141 0.0100315 9.161459000000001e-17 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0783487 0.00953163 2.206779e-16 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16709403 chr6:17470162 6 17470162 CAP2 Open sea -0.0024 0.0003 8.9e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21597596 chr6:17393825 6 17393825 CAP2 Open sea 0.00044 0.000055 8.9e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 1.7 0.214 8.9e-16 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0652721 0.00823896 0.000000000000002496911 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0989511 0.0125456 0.000000000000003304803 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.140568 0.0178539 0.000000000000003647828 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.0644234 0.00823942 0.000000000000005688612 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.0642054 0.00823954 0.000000000000007016631 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0747149 0.00966217 0.00000000000001120892 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0635503 0.00823988 0.00000000000001312598 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0740199 0.0096107 0.00000000000001426873 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0717945 0.00956565 0.00000000000006473707 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0616374 0.00824087 0.00000000000007884791 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea -0.0616054 0.00824089 0.00000000000008121197 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0608552 0.00824127 0.0000000000001616196 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0605842 0.0082414 0.0000000000002068058 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.264023 0.0359777 0.0000000000002255426 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.060438 0.00824148 0.0000000000002361409 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0600549 0.00824167 0.0000000000003337204 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0707623 0.00972016 0.0000000000003509387 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0678026 0.00936373 0.0000000000004676238 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0596134 0.00824189 0.0000000000004958788 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea 0.057927 0.00824271 0.000000000002192739 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.0575595 0.00824288 0.000000000003015104 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0572846 0.00824301 0.000000000003821033 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0704664 0.0101464 0.000000000003945967 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg22753611 chr6:17472892 6 17472892 CAP2 Open sea None None 0.0000000000044 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea -0.0641256 0.00929025 0.00000000000532065 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0567506 0.00824327 0.000000000006035283 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18449728 chr6:17393822 6 17393822 CAP2 Open sea 0.00069 None 0.0000000000062 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0700893 0.0102407 0.000000000007997426 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.238717 0.035068 0.00000000001025746 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0657894 0.00966477 0.0000000000103425 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0560079 0.00824361 0.00000000001131914 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0654665 0.00963847 0.00000000001146829 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.125502 0.0185419 0.00000000001340333 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0556194 0.00824379 0.00000000001567746 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg18876602 chr6:17393472 6 17393472 CAP2 Open sea -0.0089 0.0013 0.00000000002 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0834479 0.0125156 0.00000000002694695 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.082395 0.0123901 0.00000000003033421 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06682978 chr6:17394417 6 17394417 CAP2 Open sea 0.00035 0.000053 0.000000000031 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0640739 0.00966039 0.00000000003412834 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0544427 0.00824433 0.00000000004149469 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0543283 0.00824438 0.00000000004556145 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea -0.0541377 0.00824446 0.00000000005322329 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0637128 0.00971096 0.00000000005527193 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.063362 0.00967283 0.00000000005924943 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0666442 0.0102728 0.00000000009011472 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_4 Sun D Bogalusa Heart Study, Georgia Stress and Heart Study 31510868 2019-09-12 body mass index EFO_0004340 meta-analysis in Europeans Online Table I DNA methylation body mass index age, sex, smoking, cell composition (reference based), batch effects Beta Values kg/m2 Illumina HumanMethylation450 Whole blood None 1247 2 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.00091 None 0.000000000091 None 31510868_Sun-D_body_mass_index_meta-analysis_in_europeans Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0629867 0.0097155 0.0000000000927225 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.062237 0.0096155 0.00000000009940673 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0624759 0.00966435 0.0000000001047938 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea -0.0531324 0.00824491 0.0000000001197834 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.19131 0.0298839 0.0000000001575155 None 39706196_Hannah-M.-Smith_bmi_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.265658 0.0416905 0.0000000001911224 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea 0.052398 0.00824523 0.00000000021465 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea 0.171612 0.027052 0.000000000229509 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.185163 0.0292282 0.0000000002427775 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0522382 0.0082453 0.0000000002434535 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.060962 0.00962425 0.0000000002455331 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0611243 0.00965452 0.0000000002504071 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.228345 0.0361026 0.0000000002596008 None 39706196_Hannah-M.-Smith_body_fat_discovery Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg03282295 chr6:17418420 6 17418420 CAP2 Open sea -0.10048 0.016 0.000000000362 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.0516718 0.00824554 0.0000000003792487 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0606502 0.00967927 0.0000000003808278 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0515026 0.00824561 0.0000000004325503 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0614627 0.00989925 0.0000000005482345 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0510316 0.00824581 0.000000000622429 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Hedman AK - 28213390 2017-02-17 Serum high-density lipoprotein cholesterol EFO_0004612, CHEBI_47775 Discovery and replication Table S4 DNA methylation Serum high-density lipoprotein cholesterol Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood Inverse variance weighted fixed-effect meta-analysis 3889 4 63 Both None cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0002218 3.6e-05 0.00000000069 - 28213390_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0596386 0.00968264 0.0000000007495903 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea -0.170905 0.0277724 0.0000000007732206 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0506758 0.00824596 0.0000000008176144 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0592086 0.00964319 0.0000000008467791 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0622398 0.0101591 0.0000000009211358 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_4 Dugue PA Melbourne Collaborative Cohort Study 31552803 2019-09-25 Smoking EFO_0006527, EFO_0004318 Current vs never smoking Supplementary table 1 DNA methylation Smoking Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects M Values None Illumina HumanMethylation450 Whole blood None 1851 1 Adults Both European cg14488952 chr6:17394312 6 17394312 CAP2 Open sea 0.2 0.0327 0.000000001 None 31552803_Dugue-PA_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.0502608 0.00824614 0.000000001121306 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25227770 chr6:17413647 6 17413647 CAP2 Open sea 0.0500968 0.0082462 0.000000001269472 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.0500417 0.00824623 0.000000001323429 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea -0.0560552 0.00927407 0.000000001537071 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.167093 0.0278212 0.000000001938146 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0579037 0.00966533 0.000000002136133 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25227770 chr6:17413647 6 17413647 CAP2 Open sea 0.0493412 0.00824651 0.000000002237815 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.037 0.00627 0.0000000026 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02934347 chr6:17393628 6 17393628 CAP2 Open sea -0.048861 0.00824671 0.000000003194636 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0488437 0.00824672 0.000000003235844 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0603303 0.0102163 0.000000003597591 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0597055 0.0101964 0.000000004856873 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.168416 0.0287699 0.000000004888304 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11276986 chr6:17393616 6 17393616 CAP2 Open sea -0.0482558 0.00824695 0.00000000497993 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg25416270 chr6:17505703 6 17505703 CAP2 Open sea -0.01763 0.003 0.00000000503 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0590985 0.010142 0.000000005757495 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_4 Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg14488952 chr6:17394312 6 17394312 CAP2 Open sea 0.70800815 0.122 0.00000000644 - 25888029_ageing Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0559151 0.00964917 0.000000006980155 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18732158 chr6:17392729 6 17392729 CAP2 Open sea 0.0476412 0.0082472 0.00000000777455 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.058786 0.0101938 0.000000008239416 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Sun D Georgia Stress and Heart Study 31510868 2019-09-12 body mass index EFO_0004340 Replication in Europeans Online Table I DNA methylation body mass index age, sex, smoking, cell composition (reference based), batch effects Beta Values kg/m2 Illumina HumanMethylation450 Unspecified tissue type not specified for this cohort 252 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0014 None 0.0000000093 None 31510868_Sun-D_body_mass_index_replication_in_europeans Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.042 0.00738 0.000000014 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0466706 0.00824757 0.00000001553653 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0466633 0.00824758 0.00000001561681 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.103574 0.0183525 0.00000001691546 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02934347 chr6:17393628 6 17393628 CAP2 Open sea -0.0075 0.0013 0.000000022 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0531155 0.00951682 0.00000002430663 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0537178 0.00963897 0.0000000254835 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0459605 0.00824785 0.0000000255641 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Spiers H - 25650246 2015-02-03 Sex PATO_0000047 - Additional file 3 DNA methylation Sex Gestational age and technical covariates Beta values - Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg21183536 chr6:17393563 6 17393563 CAP2 Open sea -0.00713451 0.0013 0.000000026 - 25650246_sex Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18732158 chr6:17392729 6 17392729 CAP2 Open sea 0.0458491 0.00824789 0.00000002762309 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GZMA protein levels (SeqId = 3440-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMA protein levels (SeqId = 3440-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme A 774 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -1.13 0.204 0.000000028 None Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea 0.0458279 0.0082479 0.00000002803319 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hedman AK - 28213390 2017-02-17 Serum high-density lipoprotein cholesterol EFO_0004612, CHEBI_47775 Discovery Table S4 DNA methylation Serum high-density lipoprotein cholesterol Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 2306 2 68 Both None cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0002432 4.4e-05 0.0000000324 - 28213390_serum_highdensity_lipoprotein_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0533208 0.00964678 0.00000003307239 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0533702 0.00967187 0.0000000348521 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.026 0.00437 0.000000036 None 32795589_Kyung-WK_atopy_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0454154 0.00824805 0.00000003728312 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0554668 0.0101208 0.00000004311725 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0450969 0.00824817 0.00000004638694 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea -0.0450227 0.0082482 0.00000004879884 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea -0.037 0.00686 0.000000054 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.0503791 0.00927924 0.00000005749963 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02934347 chr6:17393628 6 17393628 CAP2 Open sea -0.044669 0.00824833 0.00000006207163 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0482786 0.00892209 0.00000006361194 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25416270 chr6:17505703 6 17505703 CAP2 Open sea 0.00083 None 0.00000007 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0514662 0.00959056 0.00000008157109 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_3 Witt S None 32080920 02-02-2020 alcohol withdrawal recovery None discovery Table S1 DNA methylation alcohol withdrawal recovery Age, Smoking, Cell composition (reference based), Batch effects Beta values None Illumina HumanMethylationEPIC whole blood two weeks after vs active withdrawal 99 1 Adults Males European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -2.9 0.501 0.000000088 None 32080920_Witt-S_alcohol_withdrawal_recovery_discovery Gadd DA Generation Scotland 35945220 31/07/2022 GZMK protein levels (SeqId = 9545-156) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMK protein levels (SeqId = 9545-156) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme K 774 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -1.09 0.204 0.000000088 None Gadd-DA_gzmk_protein_levels__seqid___9545-156__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.0440752 0.00824855 0.0000000925856 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06682978 chr6:17394417 6 17394417 CAP2 Open sea 0.0011 None 0.000000096 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.06684 0.0125271 0.0000000966342 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.159844 0.0300887 0.0000001095096 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg06741243 chr6:17447605 6 17447605 CAP2 Open sea -0.028 0.00523 0.00000011 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0436068 0.00824872 0.0000001264706 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.0451325 0.00856257 0.0000001376721 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea 0.0433798 0.0082488 0.000000146941 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0662129 0.0125925 0.0000001475736 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0507405 0.00965694 0.0000001506672 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0495611 0.00944217 0.0000001551328 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea -0.01 0.0019 0.00000017 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0430463 0.00824892 0.0000001829224 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.0430221 0.00824893 0.0000001858341 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea 0.0429397 0.00824896 0.000000196123 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0500516 0.00966562 0.0000002268643 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0501751 0.00969933 0.0000002333395 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.049905 0.00965684 0.000000239921 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0425342 0.0082491 0.0000002552569 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0946046 0.0183697 0.0000002632838 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.0424542 0.00824913 0.0000002688155 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0643625 0.0125111 0.0000002717791 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0642401 0.012527 0.0000002963267 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0526708 0.0102716 0.0000002968459 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0494044 0.00967743 0.0000003347276 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0491483 0.00966379 0.0000003705541 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0490585 0.00965013 0.0000003746915 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.041925 0.00824931 0.0000003775873 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.0418958 0.00824932 0.0000003847039 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0625528 0.0123394 0.0000004039855 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25227770 chr6:17413647 6 17413647 CAP2 Open sea 0.0417934 0.00824936 0.0000004106274 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06682978 chr6:17394417 6 17394417 CAP2 Open sea 0.00033 None 0.00000043 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -1.3 0.265 0.00000047 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0415591 0.00824944 0.0000004764929 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.043182 0.00858987 0.0000005038639 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0511536 0.010204 0.0000005418841 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18732158 chr6:17392729 6 17392729 CAP2 Open sea 0.0413198 0.00824952 0.0000005541933 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06741243 chr6:17447605 6 17447605 CAP2 Open sea -0.0415771 0.00830255 0.0000005570949 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0625635 0.0125138 0.0000005811889 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0470375 0.00941789 0.0000005967356 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0624002 0.0124967 0.0000006002362 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0628182 0.0126066 0.0000006333505 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0410544 0.00824961 0.0000006547134 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0621627 0.0124936 0.0000006579336 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0410295 0.00824962 0.0000006649716 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0508431 0.0102512 0.0000007138777 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05374569 chr6:17413083 6 17413083 CAP2 Open sea -0.00075 0.00015 0.00000077 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0406099 0.00824976 0.0000008634762 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0475844 0.00969819 0.0000009370095 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0484719 0.00991907 0.000001036036 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0470643 0.00967353 0.000001154919 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0401184 0.00824992 0.000001168885 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0610976 0.0125694 0.000001181151 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02934347 chr6:17393628 6 17393628 CAP2 Open sea 0.0043 0.00089 0.0000012 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.0399723 0.00824997 0.000001278133 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06573088 chr6:17492721 6 17492721 CAP2 Open sea -0.00057 0.00012 0.0000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.202077 0.0418068 0.000001352382 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11276986 chr6:17393616 6 17393616 CAP2 Open sea -0.0397396 0.00825005 0.00000147269 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.0397338 0.00825005 0.00000147786 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0396748 0.00825007 0.00000153176 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05374569 chr6:17413083 6 17413083 CAP2 Open sea 0.040083 0.00835063 0.00000160231 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0463944 0.00968975 0.000001701058 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05374569 chr6:17413083 6 17413083 CAP2 Open sea 0.0402633 0.00840967 0.000001703152 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0394765 0.00825014 0.000001726943 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0463859 0.00971447 0.000001815057 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.0393847 0.00825017 0.000001825233 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea -0.0393624 0.00825017 0.000001849889 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0393376 0.00825018 0.000001877665 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0392684 0.0082502 0.000001957426 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0461265 0.00972017 0.000002100193 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea -0.0391498 0.00825024 0.000002101752 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0457103 0.00964818 0.000002181645 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0482894 0.0102342 0.000002398721 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21183536 chr6:17393563 6 17393563 CAP2 Open sea 0.001 None 0.0000024 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.0388163 0.00825035 0.000002564241 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea 0.0387964 0.00825036 0.000002594668 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0387081 0.00825038 0.000002734292 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0386535 0.0082504 0.000002824106 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0479918 0.0102542 0.000002891809 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05374569 chr6:17413083 6 17413083 CAP2 Open sea 0.0386122 0.00825041 0.000002893968 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea -0.0385195 0.00825044 0.000003056815 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14488952 chr6:17394312 6 17394312 CAP2 Open sea 0.00039 None 0.0000032 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.0438904 0.00947349 0.000003635614 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0579573 0.0125267 0.000003747496 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0396953 0.00857992 0.000003750164 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0381607 0.00825056 0.000003773826 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0447764 0.00968295 0.000003791651 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Battram T GEO 27886173 2020-09-15 Ulcerative colitis EFO_0000729 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Ulcerative colitis Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 163 1 Adults Both European cg06573088 chr6:17492721 6 17492721 CAP2 Open sea -0.0259 0.00542 0.0000043 None 27886173_Battram-T_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0378533 0.00825065 0.000004513931 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0574025 0.0125332 0.0000046869 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02934347 chr6:17393628 6 17393628 CAP2 Open sea -0.0377248 0.00825069 0.000004862884 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea -0.127223 0.0278497 0.000004953507 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06741243 chr6:17447605 6 17447605 CAP2 Open sea -0.0394549 0.00863922 0.000004989009 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0376709 0.00825071 0.000005016852 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_1 Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg22753611 chr6:17472892 6 17472892 CAP2 Open sea None None 0.0000052 None 31789449_Dugue-P-A_alcohol_consumption_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.037573 0.00825074 0.0000053087 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0439606 0.009675 0.000005570857 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0559779 0.0123297 0.000005667795 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.0374571 0.00825078 0.000005674887 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.0373456 0.00825081 0.000006049889 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.0373176 0.00825082 0.00000614774 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21597596 chr6:17393825 6 17393825 CAP2 Open sea 0.0014 None 0.0000062 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Kidney Disease (Estimated) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Kidney Disease (Estimated) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18318 1 Adults (18-65y) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.044 0.00979 0.0000062 None Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Basic_model Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.022 0.00498 0.0000064 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0371796 0.00825086 0.00000665271 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.037122 0.00825088 0.000006874956 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0371002 0.00825089 0.000006960697 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0856001 0.0190462 0.000007024259 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.0415155 0.00924245 0.000007115415 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.037024 0.00825091 0.000007269146 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0557455 0.0124292 0.000007345443 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.036953 0.00825093 0.000007568723 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea -0.0369029 0.00825095 0.000007786692 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.043338 0.00970178 0.000007991136 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02934347 chr6:17393628 6 17393628 CAP2 Open sea -0.0367554 0.00825099 0.000008464401 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea 0.0366955 0.00825101 0.000008755909 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0366882 0.00825101 0.000008791819 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0431529 0.00970595 0.000008811697 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0818494 0.0184153 0.000008858821 None 39706196_Hannah-M.-Smith_body_fat_discovery Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg02934347 chr6:17393628 6 17393628 CAP2 Open sea 0.002 0.00042 0.0000089 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.0366647 0.00825102 0.000008908936 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0427628 0.00965396 0.000009510934 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06741243 chr6:17447605 6 17447605 CAP2 Open sea -0.0382318 0.00864476 0.0000098251 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06573088 chr6:17492721 6 17492721 CAP2 Open sea -0.0038 0.00086 0.00001 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.013 0.0029 0.00001 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0552518 0.0125148 0.00001017757 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11276986 chr6:17393616 6 17393616 CAP2 Open sea 0.0363411 0.00825112 0.00001068378 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0427976 0.00972071 0.00001076568 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_3 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 CD4+ T-cells Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 CD4+ T-cells - 60 1 46.5 Males European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea -0.324393 0.0737 0.0000108 None 27105112_hiv_infection_cd4_tcells Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg18876602 chr6:17393472 6 17393472 CAP2 Open sea 0.0038 0.00082 0.000011 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0377955 0.00859618 0.00001106418 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F3 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 500 1 53 Both European cg18876602 chr6:17393472 6 17393472 CAP2 Open sea - - 0.0000114 - 26500701_sex_kora_f3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.041212 0.00940504 0.00001184654 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea -0.240387 0.0548681 0.00001187285 None 39706196_Hannah-M.-Smith_bmi_discovery Gadd DA Generation Scotland 35945220 31/07/2022 FCN2 protein levels (SeqId = 13717-15) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCN2 protein levels (SeqId = 13717-15) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ficolin-2 774 1 Adults (18-65 years) Both European cg06682978 chr6:17394417 6 17394417 CAP2 Open sea 1.01 0.231 0.000012 None Gadd-DA_fcn2_protein_levels__seqid___13717-15__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0548077 0.0125217 0.00001211522 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23087150 chr6:17393647 6 17393647 CAP2 Open sea -0.036072 0.0082512 0.0000124115 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg06573088 chr6:17492721 6 17492721 CAP2 Open sea - - 0.0000125 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0359955 0.00825122 0.00001294965 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0448428 0.0102891 0.00001319876 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0419881 0.00965406 0.00001375152 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea -0.0391534 0.00900894 0.00001395335 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0422641 0.00972751 0.00001403356 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea -0.0358431 0.00825127 0.00001408848 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18732158 chr6:17392729 6 17392729 CAP2 Open sea 0.0357484 0.00825129 0.0000148433 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23013864 chr6:17393396 6 17393396 CAP2 Open sea -0.011 0.0024 0.000015 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18732158 chr6:17392729 6 17392729 CAP2 Open sea 0.0357217 0.0082513 0.00001506304 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0371943 0.00859586 0.00001521487 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.52 0.121 0.000016 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0353419 0.00825141 0.00001854503 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea -0.0352463 0.00825144 0.0000195353 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 EPO protein levels (SeqId = 5813-58) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EPO protein levels (SeqId = 5813-58) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Erythropoietin 774 1 Adults (18-65 years) Both European cg03282295 chr6:17418420 6 17418420 CAP2 Open sea -0.59 0.138 0.00002 None Gadd-DA_epo_protein_levels__seqid___5813-58__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25416270 chr6:17505703 6 17505703 CAP2 Open sea 0.03519 0.00825146 0.00002014184 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11276986 chr6:17393616 6 17393616 CAP2 Open sea -0.0351705 0.00825146 0.00002035645 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0351245 0.00825148 0.00002087016 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea 0.03511 0.00825148 0.00002103467 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01762 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01762 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0436331 0.010275 0.00002184433 P01762 41361833_Josephine_Robertson_P01762_OSCA_model_4 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea -0.94 0.222 0.000022 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0424972 0.0100126 0.00002205504 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23087150 chr6:17393647 6 17393647 CAP2 Open sea -0.0369627 0.00874074 0.00002363797 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0400004 0.00947777 0.00002452918 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea 0.0348199 0.00825156 0.00002460027 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11276986 chr6:17393616 6 17393616 CAP2 Open sea 0.0037 0.00087 0.000025 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg22753611 chr6:17472892 6 17472892 CAP2 Open sea None None 0.000025 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.0345881 0.00825163 0.00002785275 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16709403 chr6:17470162 6 17470162 CAP2 Open sea -0.0083 0.002 0.000028 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0525032 0.0125377 0.00002835193 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.041051 0.00980413 0.00002841704 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea 0.034535 0.00825165 0.0000286545 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23087150 chr6:17393647 6 17393647 CAP2 Open sea -0.0345068 0.00825165 0.00002908837 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LY9 protein levels (SeqId = 3324-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LY9 protein levels (SeqId = 3324-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: T-lymphocyte surface antigen Ly-9 774 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.85 0.203 0.00003 None Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06741243 chr6:17447605 6 17447605 CAP2 Open sea -0.0359618 0.00862499 0.00003070401 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25227770 chr6:17413647 6 17413647 CAP2 Open sea 0.0367474 0.00881959 0.00003110032 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea -0.164277 0.0394519 0.00003142652 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0343604 0.0082517 0.00003144558 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0401155 0.00965157 0.00003251837 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06741243 chr6:17447605 6 17447605 CAP2 Open sea 0.0342728 0.00825172 0.00003294161 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25416270 chr6:17505703 6 17505703 CAP2 Open sea 0.0342727 0.00825172 0.00003294291 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0422544 0.0101742 0.00003298555 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_4 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg18876602 chr6:17393472 6 17393472 CAP2 Open sea 0.00037331 8.96e-05 0.0000332 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.159556 0.0384354 0.00003321177 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0425908 0.0102726 0.00003401634 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0400022 0.00967744 0.00003591891 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0401065 0.0097282 0.00003765123 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_3 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.00015637 3.8e-05 0.0000379 - 27843151_alcohol_consumption_per_day_european_ancestry Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16709403 chr6:17470162 6 17470162 CAP2 Open sea 0.012 0.0029 0.000038 None 33450751_Mulder-RH_sex_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea -0.02 0.00484 0.000038 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0515686 0.0125382 0.00003928429 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0397646 0.00967576 0.00003982998 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11276986 chr6:17393616 6 17393616 CAP2 Open sea -0.0339054 0.00825182 0.000039981 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Neumann A ALSPAC, GENR, HELIX, GLAKU 33184255 2020-11-12 ADHD EFO_0003888 At school age Supplementary data adhd_results9 ADHD DNA methylation education level, smoking, gestational age, sex, cell composition (reference based), assessment age ADHD score Beta Values Illumina HumanMethylation450 Whole blood None 2374 9 Children Both European, South Asian cg23087150 chr6:17393647 6 17393647 CAP2 Open sea 4.209 1.32 0.00004 None 33184255_Neumann-A_adhd_at_school_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25227770 chr6:17413647 6 17413647 CAP2 Open sea -0.0339007 0.00825183 0.00004008016 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03282295 chr6:17418420 6 17418420 CAP2 Open sea -0.0342048 0.0083272 0.00004019565 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0395726 0.00963686 0.00004040942 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0338392 0.00825184 0.00004139327 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0338304 0.00825185 0.00004158469 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea -0.0337619 0.00825186 0.00004310221 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23087150 chr6:17393647 6 17393647 CAP2 Open sea -0.0337297 0.00825187 0.00004383373 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea 0.0511752 0.0125454 0.00004543024 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03282295 chr6:17418420 6 17418420 CAP2 Open sea -0.033074 0.00811204 0.00004583112 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0393543 0.00965246 0.00004583634 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06573088 chr6:17492721 6 17492721 CAP2 Open sea -0.0336073 0.00825191 0.0000467201 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23087150 chr6:17393647 6 17393647 CAP2 Open sea 0.0334892 0.00825194 0.00004967843 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.0334749 0.00825194 0.00005004945 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea 0.0334493 0.00825195 0.00005071723 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0334369 0.00825195 0.00005104364 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea 0.0363576 0.0089739 0.00005115657 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02934347 chr6:17393628 6 17393628 CAP2 Open sea -0.0333659 0.00825197 0.00005295484 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea -0.0362566 0.00897753 0.00005404479 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea 0.0333261 0.00825199 0.00005405473 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0388048 0.00966201 0.0000594318 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 NRCAM protein levels (SeqId = 5109-24) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 NRCAM protein levels (SeqId = 5109-24) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Neuronal cell adhesion molecule 774 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.74 0.185 0.00006 None Gadd-DA_nrcam_protein_levels__seqid___5109-24__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.0379449 0.00945464 0.00006015849 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0501697 0.0125131 0.00006117863 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea -1.8 0.449 0.000062 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea -0.0330374 0.00825206 0.00006270952 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.024 0.00588 0.000063 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25227770 chr6:17413647 6 17413647 CAP2 Open sea 0.0330149 0.00825207 0.00006343968 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea 0.0329862 0.00825208 0.00006437848 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg23036213 chr6:17519387 6 17519387 CAP2 Open sea -0.103254 0.0258349 0.00006449735 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg11276986 chr6:17393616 6 17393616 CAP2 Open sea - - 0.0000645 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25227770 chr6:17413647 6 17413647 CAP2 Open sea 0.0329532 0.00825209 0.0000654716 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Battram T GEO 30291105 2020-11-01 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE113904 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Colon, rectum None 232 1 Adults Both Unclear cg05374569 chr6:17413083 6 17413083 CAP2 Open sea 0.00064 0.00016 0.000067 None 30291105_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse113904 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea -0.0328885 0.0082521 0.00006767349 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18732158 chr6:17392729 6 17392729 CAP2 Open sea 0.0327989 0.00825213 0.00007083556 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11276986 chr6:17393616 6 17393616 CAP2 Open sea -0.0053 0.0013 0.000073 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0327042 0.00825215 0.00007433064 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Battram T ARIES None 2020-08-20 Arm bone mineral density EFO_0007591 None None DNA methylation Arm bone mineral density Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values g/cm2 Illumina HumanMethylation450 Whole blood DXA scan measurement 706 1 Adults Females European cg18449728 chr6:17393822 6 17393822 CAP2 Open sea 1.37 0.34 0.000075 None Battram-T_arm_bone_mineral_density Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01762 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01762 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0384919 0.00972415 0.00007581395 P01762 41361833_Josephine_Robertson_P01762_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0496077 0.0125538 0.00007799352 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Pain (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Pain (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood Fully-adjusted model 18413 1 Adults (18-65y) Both European cg26058290 chr6:17392261 6 17392261 CAP2 Open sea -0.23 0.0574 0.000078 None Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03282295 chr6:17418420 6 17418420 CAP2 Open sea -0.0323654 0.00819966 0.00007945212 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea 0.0325452 0.0082522 0.00008056529 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0380963 0.00966689 0.00008155013 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18732158 chr6:17392729 6 17392729 CAP2 Open sea 0.0324744 0.00825222 0.00008349714 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg06741243 chr6:17447605 6 17447605 CAP2 Open sea -0.11834 0.030085 0.00008404098 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25227770 chr6:17413647 6 17413647 CAP2 Open sea -0.0324513 0.00825222 0.00008447584 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Ischemic Heart Disease None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Ischemic Heart Disease Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17483 1 Adults (18-65y) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea -0.031 0.00777 0.000086 None Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21183536 chr6:17393563 6 17393563 CAP2 Open sea -0.0061 0.0016 0.000089 None 33450751_Mulder-RH_sex_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg22753611 chr6:17472892 6 17472892 CAP2 Open sea None None 0.00009 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25645553 chr6:17470599 6 17470599 CAP2 Open sea -0.0322897 0.00825227 0.00009163403 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22026442 chr6:17442621 6 17442621 CAP2 Open sea 0.0322751 0.00825227 0.00009230531 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P19652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02048478 chr6:17432613 6 17432613 CAP2 Open sea 0.0322122 0.00825229 0.00009526652 P19652 41361833_Josephine_Robertson_P19652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13355472 chr6:17431988 6 17431988 CAP2 Open sea 0.0355489 0.00910817 0.00009544319 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20110678 chr6:17493813 6 17493813 CAP2 Open sea 0.0333955 0.00858073 0.00009989404 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06741243 chr6:17447605 6 17447605 CAP2 Open sea -0.0326111 0.00837937 0.00009993262 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22753611 chr6:17472892 6 17472892 CAP2 Open sea -0.0376654 0.00967847 0.00009999623 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_2