author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.64	0	0	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05951221	chr2:233284402	2	233284402	-	Island	-0.72	0	0	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21566642	chr2:233284661	2	233284661	-	Island	-0.91	0	0	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-1.26	0	0	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03636183	chr19:17000585	19	17000585	F2RL3	North shore	-0.66	0	0	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.78	0.0233	7.900000000000001e-246	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26703534	chr5:377358	5	377358	AHRR	South shelf	-0.31	0.0125	2e-136	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14817490	chr5:392920	5	392920	AHRR	Open sea	-0.46	0.0185	2.4e-136	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.52	0.021	6.699999999999999e-135	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25648203	chr5:395444	5	395444	AHRR	Open sea	-0.39	0.017	2e-116	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19859270	chr3:98251294	3	98251294	GPR15	Open sea	-0.4	0.0188	1.3e-100	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09935388	chr1:92947588	1	92947588	GFI1	Island	-0.56	0.0273	2.3e-93	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23576855	chr5:373299	5	373299	AHRR	North shore	-1.06	0.0529	1.8e-89	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25189904	chr1:68299493	1	68299493	GNG12	South shore	-0.47	0.0257	1.8e-74	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22132788	chr7:45002486	7	45002486	MYO1G	Island	0.76	0.0419	1.1e-73	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21611682	chr11:68138269	11	68138269	LRP5	Open sea	-0.21	0.0116	1.4e-73	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11660018	chr11:86510915	11	86510915	PRSS23	North shore	-0.26	0.0144	6.4e-73	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14753356	chr6:30720108	6	30720108	-	Open sea	-0.26	0.0145	4.2e-72	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06644428	chr2:233284112	2	233284112	-	Island	-0.61	0.0344	2.3999999999999998e-70	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24859433	chr6:30720203	6	30720203	-	Open sea	-0.27	0.0155	3.2e-68	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23161492	chr15:90357202	15	90357202	ANPEP	North shore	-0.36	0.0207	1.5e-67	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03991871	chr5:368447	5	368447	AHRR	North shore	-0.48	0.028	5.000000000000001e-66	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23079012	chr2:8343710	2	8343710	-	Open sea	-0.78	0.0458	3.6000000000000002e-65	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03329539	chr2:233283329	2	233283329	-	North shore	-0.36	0.0212	7e-65	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25949550	chr7:145814306	7	145814306	CNTNAP2	South shore	-0.28	0.0165	8.7e-65	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04885881	chr1:11123118	1	11123118	-	South shelf	-0.26	0.0157	2.1e-61	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12803068	chr7:45002919	7	45002919	MYO1G	South shore	0.6	0.0367	4.0000000000000004e-60	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23771366	chr11:86510998	11	86510998	PRSS23	North shore	-0.26	0.0162	5.4000000000000005e-58	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23916896	chr5:368804	5	368804	AHRR	North shore	-0.45	0.0281	6.7e-58	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08709672	chr1:206224334	1	206224334	AVPR1B	South shore	-0.16	0.01	7.8e-58	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11902777	chr5:368843	5	368843	AHRR	North shore	-0.42	0.0263	2.5e-57	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12876356	chr1:92946825	1	92946825	GFI1	Island	-0.4	0.0253	1.8e-56	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12513616	chr5:177370977	5	177370977	-	Island	-0.17	0.0108	1.7999999999999997e-55	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27537125	chr1:25349681	1	25349681	-	Open sea	-0.23	0.0149	7.6e-54	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15342087	chr6:30720209	6	30720209	-	Open sea	-0.23	0.015	4.3e-53	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00310412	chr15:74724918	15	74724918	SEMA7A	North shore	-0.17	0.0111	7.099999999999999e-53	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08035323	chr2:9843525	2	9843525	-	Open sea	0.34	0.0224	5.1e-52	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19572487	chr17:38476024	17	38476024	RARA	South shore	-0.27	0.0179	1.3e-51	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07826859	chr7:45020086	7	45020086	MYO1G	Open sea	-0.2	0.0133	2.6e-51	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03604011	chr5:400201	5	400201	AHRR	Open sea	0.42	0.0281	1.2e-50	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07339236	chr20:50312490	20	50312490	ATP9A	Open sea	-0.33	0.0222	4.9e-50	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17287155	chr5:393347	5	393347	AHRR	Open sea	-0.26	0.0176	1.9e-49	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18146737	chr1:92946700	1	92946700	GFI1	Island	-0.67	0.046	4.4e-48	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26361535	chr8:144576604	8	144576604	ZC3H3	Open sea	-0.3	0.0206	5.1e-48	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11207515	chr7:146904205	7	146904205	CNTNAP2	Open sea	0.32	0.0222	5.1e-47	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21322436	chr7:145812842	7	145812842	CNTNAP2	North shore	-0.22	0.0154	1.9e-46	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14580211	chr5:150161299	5	150161299	C5orf62	South shelf	-0.28	0.0198	1.7e-45	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05284742	chr14:93552128	14	93552128	ITPK1	Open sea	-0.21	0.0151	6.7e-44	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00501876	chr3:39193251	3	39193251	CSRNP1	North shore	-0.15	0.011	1.9999999999999998e-42	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03707168	chr19:49379127	19	49379127	PPP1R15A	South shelf	-0.29	0.0213	2.6e-42	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04551776	chr5:393366	5	393366	AHRR	Open sea	-0.23	0.0171	1.8e-41	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01901332	chr11:75031054	11	75031054	ARRB1	Open sea	-0.22	0.0165	1.3e-40	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02583484	chr12:54677008	12	54677008	HNRNPA1;HNRPA1L-2	South shelf	-0.16	0.0121	9.1e-40	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12806681	chr5:368394	5	368394	AHRR	North shore	-0.36	0.0273	1.3e-39	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12547807	chr1:9473751	1	9473751	-	Open sea	-0.16	0.0123	7.799999999999999e-39	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01127300	chr22:38614796	22	38614796	-	South shelf	-0.23	0.0176	7.799999999999999e-39	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24838345	chr8:125737353	8	125737353	MTSS1	North shelf	-0.29	0.0223	1.3e-38	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26271591	chr2:178125956	2	178125956	NFE2L2	North shelf	-0.24	0.0186	3.2000000000000003e-38	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01899089	chr5:369969	5	369969	AHRR	North shore	-0.18	0.014	1.1e-37	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21913886	chr1:15485346	1	15485346	TMEM51	South shelf	-0.25	0.0196	2.1e-37	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27241845	chr2:233250370	2	233250370	-	North shore	-0.25	0.0196	2.7e-37	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03274391	chr3:22413232	3	22413232	-	North shore	0.51	0.0405	2.5e-36	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23480021	chr3:22412746	3	22412746	-	North shore	0.56	0.0446	3.8000000000000004e-36	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02451831	chr7:26578098	7	26578098	KIAA0087	Open sea	-0.19	0.0152	5.5000000000000005e-36	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25560398	chr2:233252170	2	233252170	ECEL1P2	Island	-0.09	0.0073	2.7e-35	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10420527	chr11:68138505	11	68138505	LRP5	Open sea	-0.11	0.009	1.1e-34	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24556382	chr4:174173455	4	174173455	GALNT7	Open sea	-0.27	0.022	1.3e-34	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03450842	chr10:80834947	10	80834947	ZMIZ1	Open sea	-0.17	0.014	4.5e-34	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18316974	chr1:92947035	1	92947035	GFI1	Island	-0.5	0.0412	6.5e-34	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10750182	chr10:73497514	10	73497514	C10orf105;CDH23	Open sea	-0.11	0.0091	1.2e-33	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09099830	chr16:30485485	16	30485485	ITGAL	Island	-0.17	0.0141	1.7e-33	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21121843	chr4:3203982	4	3203982	HTT	Open sea	-0.26	0.0216	1.8e-33	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12075928	chr8:141801307	8	141801307	PTK2	Open sea	-0.23	0.0191	1.8e-33	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13039251	chr5:32018601	5	32018601	PDZD2	Open sea	0.28	0.0232	2.1000000000000003e-33	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13038618	chr14:77467391	14	77467391	-	Open sea	-0.19	0.0158	3.7e-33	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25305703	chr8:128378218	8	128378218	-	Open sea	-0.25	0.0212	4.6e-32	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18826637	chr2:145116633	2	145116633	-	Open sea	-0.35	0.0298	6.100000000000001e-32	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24090911	chr5:400732	5	400732	AHRR	Open sea	-0.22	0.0187	7e-32	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20059012	chr12:53613154	12	53613154	RARG	North shore	-0.49	0.0417	7.8e-32	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09662411	chr1:92946132	1	92946132	GFI1	Island	-0.2	0.0171	1.4e-31	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18754985	chr3:98237750	3	98237750	CLDND1	North shelf	-0.23	0.0197	1.5999999999999999e-31	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13074055	chr14:106329206	14	106329206	-	Open sea	-0.41	0.0351	1.9e-31	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01294327	chr19:2291373	19	2291373	LINGO3	Island	-0.35	0.03	2.3e-31	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23090529	chr1:51442133	1	51442133	-	North shore	-0.27	0.0233	5.3e-31	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25953130	chr10:63753550	10	63753550	ARID5B	Open sea	-0.22	0.0191	9.999999999999999e-31	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26963277	chr11:2722407	11	2722407	KCNQ1OT1;KCNQ1	South shore	-0.3	0.0261	1.8e-30	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05875421	chr14:91709951	14	91709951	GPR68	Open sea	-0.23	0.0201	2.8000000000000002e-30	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19254163	chr11:60623782	11	60623782	GPR44	South shelf	-0.18	0.0158	3.6e-30	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24996979	chr14:74223355	14	74223355	C14orf43	North shelf	-0.19	0.0167	7.4e-30	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20059928	chr15:40361485	15	40361485	-	Open sea	-0.22	0.0195	1.8e-29	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13518625	chr8:29522838	8	29522838	-	Open sea	-0.34	0.0302	2.3e-29	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05673882	chr5:74862702	5	74862702	POLK	Open sea	-0.21	0.0187	3.7e-29	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24049493	chr1:42385941	1	42385941	HIVEP3	South shore	0.38	0.0342	1.1000000000000002e-28	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07178945	chr12:4488800	12	4488800	FGF23	Open sea	0.19	0.0171	1.1000000000000002e-28	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05221370	chr7:110738836	7	110738836	LRRN3;IMMP2L	Open sea	-0.26	0.0234	1.4000000000000001e-28	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07986378	chr12:11898284	12	11898284	ETV6	Open sea	-0.24	0.0217	2.0000000000000002e-28	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23110422	chr21:40182073	21	40182073	ETS2	South shelf	-0.23	0.0208	2.1e-28	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14624207	chr11:68142198	11	68142198	LRP5	Open sea	-0.15	0.0136	2.3000000000000003e-28	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07069636	chr16:30671749	16	30671749	-	South shore	-0.13	0.0118	3.5000000000000004e-28	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16145216	chr1:42385662	1	42385662	HIVEP3	South shore	0.2	0.0183	7.900000000000001e-28	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09658497	chr7:2847517	7	2847517	GNA12	Open sea	-0.35	0.0321	1e-27	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03646329	chr13:48987165	13	48987165	LPAR6;RB1	Open sea	-0.26	0.0239	1.6000000000000001e-27	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17924476	chr5:323794	5	323794	AHRR	South shore	0.23	0.0212	2.1e-27	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19717773	chr7:2847554	7	2847554	GNA12	Open sea	-0.31	0.0286	2.3e-27	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01015663	chr1:23729692	1	23729692	TCEA3	Open sea	-0.16	0.0148	2.4e-27	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21869609	chr19:2291613	19	2291613	LINGO3	Island	-0.4	0.0371	3.9000000000000004e-27	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01513913	chr14:106329158	14	106329158	-	Open sea	-0.14	0.013	5.5e-27	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19956914	chr7:56147257	7	56147257	SUMF2	Open sea	0.2	0.0186	7.2e-27	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06235438	chr16:30485966	16	30485966	ITGAL	South shore	-0.19	0.0177	8.9e-27	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19827923	chr2:231790777	2	231790777	GPR55	Open sea	-0.15	0.0142	3e-26	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26470501	chr19:45252955	19	45252955	BCL3	South shore	-0.12	0.0113	3.2e-26	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21393163	chr1:12217629	1	12217629	-	Open sea	-0.23	0.0217	3.8e-26	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23973524	chr19:18873222	19	18873222	CRTC1	Island	0.16	0.0152	4.8e-26	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07123182	chr11:2722391	11	2722391	KCNQ1OT1;KCNQ1	South shore	-0.33	0.0313	5.1e-26	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11231349	chr1:162050656	1	162050656	NOS1AP	Open sea	-0.28	0.0267	8.6e-26	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15159987	chr19:17003890	19	17003890	CPAMD8	North shelf	-0.15	0.0143	1.2e-25	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13525276	chr14:81426012	14	81426012	TSHR	Open sea	0.18	0.0172	1.4e-25	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20295214	chr1:206226794	1	206226794	AVPR1B	South shelf	-0.22	0.0212	3.1e-25	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17619755	chr6:31760629	6	31760629	VARS	North shelf	0.16	0.0155	4.2e-25	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02657160	chr3:98311063	3	98311063	CPOX	North shore	-0.2	0.0194	5.8e-25	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17087741	chr2:233283010	2	233283010	-	North shore	-0.33	0.032	6.699999999999999e-25	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15542713	chr1:42385581	1	42385581	HIVEP3	South shore	0.26	0.0253	9.7e-25	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16611234	chr11:58870075	11	58870075	-	Island	-0.21	0.0205	1.2999999999999998e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07251887	chr17:73641809	17	73641809	LOC100130933;RECQL5	Open sea	-0.12	0.0118	1.8999999999999998e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08972170	chr7:30185776	7	30185776	C7orf41	Open sea	0.2	0.0196	2.2999999999999997e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11556164	chr7:110738315	7	110738315	LRRN3;IMMP2L	Open sea	-0.19	0.0187	2.9e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15474579	chr6:36645812	6	36645812	CDKN1A	North shore	-0.16	0.0158	3.0999999999999997e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05329352	chr10:112838983	10	112838983	ADRA2A	Island	-0.2	0.0198	4.5e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01207684	chr16:4103167	16	4103167	ADCY9	Open sea	-0.24	0.0238	5.8999999999999995e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06459104	chr18:5456880	18	5456880	EPB41L3	Open sea	-0.29	0.0287	6e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20066188	chr22:37678791	22	37678791	CYTH4	Open sea	-0.2	0.0198	6.0999999999999996e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00741986	chr4:2748332	4	2748332	TNIP2	Open sea	-0.13	0.0129	6.7e-24	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01763916	chr1:40849202	1	40849202	SMAP2	Open sea	-0.18	0.018	2.0000000000000002e-23	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23667432	chr2:233244439	2	233244439	ALPP	Island	-0.14	0.014	2.0000000000000002e-23	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25212025	chr10:34602937	10	34602937	PARD3	Open sea	-0.16	0.0161	2.4e-23	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00871610	chr21:37093012	21	37093012	MIR802	Open sea	-0.16	0.0161	2.8000000000000003e-23	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15417641	chr3:53700141	3	53700141	CACNA1D	Open sea	0.27	0.0272	3.5e-23	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01692968	chr9:108005349	9	108005349	-	North shore	-0.18	0.0182	3.6e-23	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00711496	chr19:50191497	19	50191497	C19orf76;PRMT1	Island	-0.3	0.0304	5.4e-23	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13937905	chr12:53612551	12	53612551	RARG	North shore	-0.26	0.0264	5.9e-23	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18446336	chr7:2847575	7	2847575	GNA12	Open sea	-0.23	0.0234	7.8e-23	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12873476	chr8:142402728	8	142402728	-	South shore	-0.19	0.0194	1.3e-22	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20778199	chr6:148020881	6	148020881	-	Open sea	-0.22	0.0225	1.6000000000000002e-22	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16047567	chr1:12664243	1	12664243	DHRS3	Open sea	-0.17	0.0175	2.8000000000000004e-22	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02228160	chr5:143192067	5	143192067	HMHB1	Open sea	0.14	0.0144	3.2000000000000003e-22	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02532700	chr22:37257404	22	37257404	NCF4	Open sea	-0.24	0.0249	6e-22	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13787850	chr9:102195951	9	102195951	-	Open sea	-0.18	0.0188	8.9e-22	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17372101	chr7:147500722	7	147500722	CNTNAP2	Open sea	0.16	0.0167	1e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26764244	chr1:68299511	1	68299511	GNG12	South shore	-0.26	0.0272	1.3e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10691866	chr7:65817282	7	65817282	TPST1	Open sea	-0.16	0.0168	1.4e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21747070	chr5:957535	5	957535	-	North shore	-0.15	0.0157	1.6e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23126342	chr13:67801125	13	67801125	PCDH9	North shelf	0.23	0.0242	1.7e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19940644	chr1:12112386	1	12112386	-	Open sea	-0.22	0.0231	1.8e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01208318	chr14:106329652	14	106329652	-	North shelf	-0.26	0.0275	2.9e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23594345	chr14:106329607	14	106329607	-	North shelf	-0.27	0.0286	3.6e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14712058	chr19:16988083	19	16988083	SIN3B	North shore	-0.16	0.017	4.7e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21446172	chr1:223745234	1	223745234	CAPN8	South shore	-0.15	0.0159	4.9e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07094298	chr4:2748026	4	2748026	TNIP2	Open sea	-0.2	0.0213	6e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15693572	chr3:22412385	3	22412385	-	North shore	0.29	0.0309	7.2e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01882991	chr6:6677756	6	6677756	-	Open sea	-0.12	0.0128	7.2e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13541527	chr6:31804078	6	31804078	C6orf48;SNORD52	South shore	-0.21	0.0224	8e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00073090	chr19:1265879	19	1265879	-	Island	-0.14	0.015	8.4e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04224247	chrX:9984515	X	9984515	WWC3	Island	-0.25	0.0268	9.9e-21	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03295554	chr11:128395450	11	128395450	ETS1	South shelf	-0.21	0.0225	1e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26529655	chr5:424371	5	424371	AHRR	South shelf	-0.08	0.0086	1.3e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20244340	chr20:19193989	20	19193989	SLC24A3	South shore	-0.17	0.0183	1.4e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06433467	chr5:67730071	5	67730071	-	Open sea	-0.28	0.0301	1.5e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07180646	chr1:15481541	1	15481541	TMEM51	South shore	-0.17	0.0183	1.8e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11405655	chr1:999599	1	999599	-	North shore	-0.17	0.0184	2.2e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16519923	chr16:30485810	16	30485810	ITGAL	South shore	-0.16	0.0173	2.4e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12303084	chr20:45985741	20	45985741	ZMYND8	Open sea	-0.15	0.0162	2.4e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20303561	chr14:91881497	14	91881497	CCDC88C	North shore	-0.16	0.0173	2.9e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11554391	chr5:321320	5	321320	AHRR	Island	-0.23	0.0249	3e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22635676	chr2:241975971	2	241975971	SNED1	Island	0.57	0.062	3.8e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08257009	chr14:94812770	14	94812770	-	Open sea	-0.13	0.0142	5.3e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09502149	chr1:43406792	1	43406792	SLC2A1	Open sea	-0.1	0.0109	5.8e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01731783	chr14:74211788	14	74211788	C14orf43	Open sea	-0.09	0.0098	6.2e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08266095	chr5:123149716	5	123149716	-	Open sea	-0.18	0.0197	7.3e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15344028	chr2:204801510	2	204801510	ICOS	Open sea	-0.19	0.0209	8.5e-20	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10874644	chr5:83898708	5	83898708	-	Open sea	0.21	0.0231	1.1e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21091547	chr6:36645500	6	36645500	CDKN1A	North shore	-0.2	0.022	1.1e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26718213	chr2:241976080	2	241976080	SNED1	Island	0.31	0.0342	1.2e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19589396	chr8:103937374	8	103937374	-	Open sea	-0.16	0.0177	1.3e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09837977	chr7:110731201	7	110731201	LRRN3;IMMP2L	Open sea	-0.15	0.0166	1.5e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20886049	chr11:76493545	11	76493545	TSKU	North shore	-0.15	0.0167	2.2e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00835193	chr19:2291780	19	2291780	LINGO3	Island	-0.19	0.0211	2.2e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15114651	chr19:47289410	19	47289410	SLC1A5	North shore	-0.07	0.0078	3.1e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06946797	chr16:11422409	16	11422409	-	Open sea	-0.19	0.0212	3.4e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13193840	chr2:233285289	2	233285289	-	Island	-0.2	0.0223	3.5e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15187398	chr19:2093896	19	2093896	MOBKL2A	North shore	-0.15	0.0168	4.3e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21188533	chr3:53700263	3	53700263	CACNA1D	Open sea	0.29	0.0325	4.8e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02610360	chr11:120197521	11	120197521	TMEM136	South shore	0.19	0.0213	4.8e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25748521	chr7:139366758	7	139366758	HIPK2	Open sea	-0.14	0.0158	6.7e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12147622	chr10:74021432	10	74021432	-	South shore	-0.15	0.0169	7e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08549335	chr7:30387954	7	30387954	ZNRF2	Open sea	-0.23	0.0259	7.3e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01873977	chr8:125699897	8	125699897	MTSS1	Open sea	-0.19	0.0214	7.7e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27312979	chr10:97094453	10	97094453	SORBS1	Open sea	0.2	0.0226	8.4e-19	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19719391	chr4:26789915	4	26789915	-	Open sea	0.13	0.0147	1e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16861076	chr8:11421594	8	11421594	BLK	Island	0.35	0.0396	1e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26707709	chr2:241975756	2	241975756	SNED1	Island	0.36	0.0408	1.1e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16071219	chr13:48986124	13	48986124	LPAR6;RB1	Open sea	-0.15	0.017	1.1e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16391678	chr16:30485597	16	30485597	ITGAL	Island	-0.13	0.0147	1.1e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17024919	chr3:21792248	3	21792248	ZNF385D	Open sea	-0.27	0.0307	1.3e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06321596	chr16:17562960	16	17562960	XYLT1	Open sea	-0.16	0.0182	1.4e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11314684	chr1:244006288	1	244006288	AKT3	Open sea	-0.12	0.0137	1.5e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03047995	chr14:24601588	14	24601588	FITM1	Island	0.12	0.0137	1.5e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06819357	chr14:102928437	14	102928437	TECPR2	Open sea	0.12	0.0137	1.9e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10062919	chr17:38503802	17	38503802	RARA	South shore	-0.08	0.0091	2.2e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18625627	chr14:81426015	14	81426015	TSHR	Open sea	0.17	0.0195	2.6e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09022230	chr7:5457225	7	5457225	TNRC18	North shore	-0.16	0.0184	3.5e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17907003	chr1:117533414	1	117533414	-	Open sea	-0.16	0.0184	3.8e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25809905	chr17:42467728	17	42467728	ITGA2B	Open sea	0.16	0.0184	4.1e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05194346	chr15:101305443	15	101305443	-	Open sea	0.16	0.0185	4.3e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18181703	chr17:76354621	17	76354621	SOCS3	North shore	-0.12	0.0139	5.2e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11621113	chr19:12776725	19	12776725	MORG1;MAN2B1	North shore	-0.13	0.0151	6.7e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05655806	chr3:111260756	3	111260756	CD96	Open sea	-0.19	0.0221	7.1e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00336149	chr3:53700195	3	53700195	CACNA1D	Open sea	0.16	0.0186	8e-18	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14316231	chr8:41895100	8	41895100	MYST3	Open sea	-0.1	0.0117	1.1e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20045320	chr11:319555	11	319555	-	South shore	-0.18	0.021	1.2e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24149237	chr11:117687628	11	117687628	-	Open sea	-0.11	0.0129	1.2e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13916835	chr17:2078431	17	2078431	SMG6	Open sea	-0.19	0.0222	1.2e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08038054	chr7:93550781	7	93550781	GNG11	Open sea	0.18	0.0211	1.3e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17580614	chr17:15849512	17	15849512	ADORA2B	Island	-0.18	0.0211	1.4e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00541303	chr1:208962374	1	208962374	-	Open sea	-0.13	0.0152	1.5e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10965178	chr1:43766752	1	43766752	TIE1	North shelf	-0.11	0.0129	1.5e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13184736	chr1:68299409	1	68299409	GNG12	South shore	-0.23	0.027	1.5e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05438378	chr15:67383736	15	67383736	SMAD3	Open sea	-0.17	0.02	1.9e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24688690	chr5:345850	5	345850	AHRR	South shore	-0.07	0.0082	2.1e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22870429	chr3:114027859	3	114027859	TIGIT	Open sea	-0.13	0.0153	2.2e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23067299	chr5:323907	5	323907	AHRR	South shore	0.22	0.0261	3.1e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00378510	chr19:2291020	19	2291020	LINGO3	Island	-0.2	0.0237	3.1e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22851200	chr7:100465833	7	100465833	TRIP6	South shore	-0.16	0.019	3.3e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24389054	chr7:27194013	7	27194013	HOXA7	North shore	-0.18	0.0214	3.5e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06595162	chr21:40141040	21	40141040	NCRNA00114	Open sea	-0.11	0.0131	4.5e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13185177	chr3:194119885	3	194119885	GP5	South shore	0.16	0.0191	4.7e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25323554	chr17:27135257	17	27135257	C17orf63	North shelf	-0.11	0.0132	6.1e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11014740	chr2:129079223	2	129079223	-	North shore	-0.09	0.0108	6.7e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23205886	chr5:138611766	5	138611766	SNHG4;MATR3	South shore	-0.09	0.0108	6.9e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03547355	chr1:227003060	1	227003060	-	Open sea	-0.11	0.0132	7.3e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07742396	chr1:27853060	1	27853060	-	North shore	-0.09	0.0108	7.3e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03109660	chr4:37684505	4	37684505	RELL1	North shelf	-0.12	0.0144	9e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14371731	chr10:81003175	10	81003175	ZMIZ1	Island	0.56	0.0674	9.4e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25292882	chr15:39431467	15	39431467	-	Open sea	-0.16	0.0192	9.4e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23233742	chr5:139077894	5	139077894	-	South shore	-0.11	0.0132	9.6e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26337070	chr2:85999873	2	85999873	ATOH8	Open sea	-0.18	0.0217	9.8e-17	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24448421	chr12:68737061	12	68737061	-	Open sea	0.14	0.0169	1.1e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24173182	chr17:1961286	17	1961286	HIC1	Island	0.12	0.0145	1.1e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09465703	chr16:733842	16	733842	JMJD8	Island	-0.2	0.0241	1.2e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24174557	chr17:57903544	17	57903544	TMEM49	Open sea	-0.15	0.0181	1.2e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02998240	chr1:16508668	1	16508668	-	Open sea	-0.2	0.0243	1.7e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26669717	chr7:641028	7	641028	PRKAR1B	North shelf	-0.09	0.0109	1.7e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05603985	chr1:2161049	1	2161049	SKI	Island	-0.09	0.0109	1.8e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09069072	chr1:15482753	1	15482753	TMEM51	South shore	-0.27	0.0328	1.8e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02734358	chr4:90227074	4	90227074	GPRIN3	North shore	-0.15	0.0183	2.1e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01744331	chr11:2722358	11	2722358	KCNQ1OT1;KCNQ1	South shore	-0.24	0.0292	2.2e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16969872	chr13:79968324	13	79968324	RBM26	Open sea	-0.15	0.0183	2.4e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15815084	chr17:54912870	17	54912870	DGKE	South shore	-0.21	0.0256	2.5e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00931843	chr6:155442993	6	155442993	TIAM2	Open sea	0.15	0.0183	2.6e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10581837	chr13:76334707	13	76334707	LMO7	Open sea	0.12	0.0147	2.7e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23681440	chr13:27498239	13	27498239	-	Open sea	-0.12	0.0147	2.7e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00295485	chr2:106755721	2	106755721	UXS1	Open sea	-0.15	0.0183	2.8e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00548098	chr16:11295667	16	11295667	-	Open sea	-0.13	0.0159	3e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19372602	chr1:156116207	1	156116207	-	Open sea	-0.15	0.0184	3.3e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04359840	chr16:17563300	16	17563300	XYLT1	Open sea	-0.13	0.0159	3.3e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14179389	chr1:92947961	1	92947961	GFI1	Island	-0.22	0.027	3.8e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05339037	chr19:13951168	19	13951168	-	North shelf	-0.08	0.0098	4.2e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16503724	chr3:17130667	3	17130667	PLCL2	Open sea	0.1	0.0123	4.3e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19713851	chr2:233246594	2	233246594	ALPP	South shore	-0.24	0.0296	4.7e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06338710	chr1:92946187	1	92946187	GFI1	Island	-0.16	0.0197	5.2e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17417856	chr19:50191637	19	50191637	PRMT1;C19orf76	North shore	-0.1	0.0123	5.6e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05396397	chr1:11908164	1	11908164	NPPA	Open sea	0.14	0.0173	5.9e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11436113	chr20:19191145	20	19191145	-	North shore	-0.11	0.0136	5.9e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26889659	chr6:684090	6	684090	EXOC2	Open sea	-0.26	0.0321	6.1e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23169111	chr20:3065582	20	3065582	AVP	South shore	0.08	0.0099	7e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22904711	chr19:44278628	19	44278628	KCNN4	Island	-0.15	0.0186	7.4e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16936953	chr17:57915665	17	57915665	TMEM49	Open sea	-0.15	0.0186	7.5e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10919522	chr14:74227441	14	74227441	C14orf43	South shore	-0.17	0.0212	9.5e-16	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12423733	chr6:29454623	6	29454623	MAS1L	Open sea	0.22	0.0274	0.000000000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07465627	chr17:53167407	17	53167407	STXBP4	Open sea	-0.1	0.0125	0.000000000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26701785	chr6:158448455	6	158448455	SYNJ2	Open sea	0.25	0.0312	0.0000000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24154132	chr14:103367632	14	103367632	TRAF3	Open sea	0.11	0.0137	0.0000000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19838043	chr14:104196038	14	104196038	ZFYVE21	South shore	0.13	0.0163	0.0000000000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13500388	chr16:67062135	16	67062135	CBFB	North shore	-0.11	0.0138	0.0000000000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21140898	chr1:51442318	1	51442318	-	North shore	-0.19	0.0239	0.0000000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14074174	chr19:7986206	19	7986206	SNAPC2	South shore	-0.08	0.01	0.0000000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05302489	chr6:31760426	6	31760426	VARS	North shelf	0.16	0.0202	0.0000000000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09109520	chr16:57673258	16	57673258	GPR56	Open sea	0.14	0.0177	0.0000000000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16033053	chr10:28034794	10	28034794	MKX	Island	0.26	0.0328	0.0000000000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04716530	chr16:30485684	16	30485684	ITGAL	Island	-0.11	0.0139	0.0000000000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03999941	chr5:957511	5	957511	-	North shore	-0.15	0.019	0.0000000000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15554421	chr3:99792561	3	99792561	C3orf26;FILIP1L	Open sea	-0.16	0.0202	0.0000000000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03340878	chr6:27925166	6	27925166	OR2B6	Open sea	-0.16	0.0202	0.0000000000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22698028	chr5:400494	5	400494	AHRR	Open sea	0.12	0.0152	0.0000000000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04158018	chr12:54696210	12	54696210	NFE2	Open sea	-0.16	0.0203	0.0000000000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05478824	chr17:79970135	17	79970135	ASPSCR1	South shelf	-0.12	0.0152	0.0000000000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00464046	chr7:134854551	7	134854551	C7orf49	North shore	-0.13	0.0165	0.0000000000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12616487	chr11:62379063	11	62379063	ROM1;EML3	North shore	-0.1	0.0127	0.0000000000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16116321	chr2:225244609	2	225244609	FAM124B	Open sea	-0.11	0.014	0.0000000000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16983588	chr11:129793108	11	129793108	PRDM10	Open sea	0.17	0.0216	0.0000000000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12758082	chr13:113407769	13	113407769	ATP11A	North shelf	0.07	0.0089	0.0000000000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13543915	chr9:134293793	9	134293793	-	Open sea	-0.09	0.0115	0.0000000000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24033122	chr16:30485383	16	30485383	ITGAL	Island	-0.2	0.0255	0.0000000000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08763102	chr4:3079751	4	3079751	HTT	South shelf	-0.09	0.0115	0.0000000000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21733098	chr12:127931219	12	127931219	-	Open sea	-0.24	0.0306	0.0000000000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19137417	chr17:79362935	17	79362935	-	South shore	-0.14	0.0179	0.0000000000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09570614	chr2:112124380	2	112124380	-	Open sea	0.08	0.0102	0.0000000000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10190813	chr7:48018530	7	48018530	HUS1	North shore	-0.16	0.0204	0.000000000000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10520740	chr12:1952798	12	1952798	CACNA2D4	Open sea	-0.09	0.0115	0.0000000000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11666770	chr19:42430910	19	42430910	-	North shore	-0.31	0.0397	0.0000000000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17990365	chr11:319718	11	319718	IFITM3	South shore	-0.14	0.0179	0.0000000000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12076915	chr19:42430253	19	42430253	-	North shore	-0.12	0.0154	0.0000000000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12406027	chr19:39616818	19	39616818	PAK4	Island	-0.08	0.0103	0.0000000000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22441770	chr1:153929592	1	153929592	CRTC2	North shore	-0.09	0.0116	0.0000000000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03485667	chr16:75143200	16	75143200	ZNRF1	Open sea	-0.1	0.0129	0.0000000000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19713429	chr1:19810690	1	19810690	CAPZB	North shore	-0.16	0.0206	0.0000000000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02714303	chr13:76334728	13	76334728	LMO7	Open sea	0.13	0.0168	0.0000000000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04018738	chr6:31760616	6	31760616	VARS	North shelf	0.2	0.0259	0.000000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18082788	chr6:149806339	6	149806339	ZC3H12D	Open sea	-0.25	0.0324	0.000000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01481251	chr11:32912719	11	32912719	-	North shore	-0.19	0.0246	0.000000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27467282	chr13:52116184	13	52116184	-	Open sea	0.13	0.0168	0.000000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06193043	chr1:11908199	1	11908199	NPPA	Open sea	0.16	0.0207	0.000000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10788371	chr11:76381040	11	76381040	LRRC32	North shore	-0.12	0.0156	0.000000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11649376	chr12:81473234	12	81473234	ACSS3	South shore	-0.11	0.0143	0.000000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07512814	chr19:11203661	19	11203661	LDLR	South shore	-0.17	0.022	0.000000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06394460	chr13:28130393	13	28130393	LNX2	Open sea	-0.18	0.0234	0.000000000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07626482	chr19:47289503	19	47289503	SLC1A5	North shore	-0.08	0.0104	0.000000000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22998476	chr10:74058092	10	74058092	-	South shore	-0.12	0.0156	0.000000000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11735008	chr1:42380309	1	42380309	HIVEP3	North shelf	0.17	0.0221	0.000000000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16705546	chr16:85936666	16	85936666	IRF8	South shelf	0.14	0.0182	0.000000000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10399789	chr1:92945668	1	92945668	GFI1	North shore	-0.19	0.0248	0.000000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20563269	chr2:129104576	2	129104576	-	South shore	-0.16	0.0209	0.000000000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20267101	chr3:113006232	3	113006232	BOC;WDR52	Open sea	-0.11	0.0144	0.000000000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09701700	chr10:104194843	10	104194843	MIR146B	South shelf	-0.14	0.0183	0.000000000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12593793	chr1:156074135	1	156074135	-	Open sea	-0.1	0.0131	0.000000000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00687135	chr3:21792991	3	21792991	ZNF385D	Open sea	-0.17	0.0223	0.000000000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19089201	chr7:45002287	7	45002287	MYO1G	Island	0.21	0.0275	0.000000000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11028075	chr10:97200911	10	97200911	SORBS1	Open sea	0.14	0.0184	0.000000000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14099685	chr11:47546068	11	47546068	CUGBP1	Open sea	-0.07	0.0092	0.000000000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24086068	chr4:77356008	4	77356008	SHROOM3	Open sea	-0.17	0.0223	0.000000000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24342283	chr11:118758603	11	118758603	CXCR5	Open sea	-0.09	0.0118	0.000000000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10920224	chr14:103367591	14	103367591	TRAF3	Open sea	0.25	0.0328	0.000000000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20385395	chr5:138613030	5	138613030	SNHG4;SNORA74A;MATR3	South shelf	-0.09	0.0118	0.000000000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06285727	chr11:72524028	11	72524028	ATG16L2	North shore	-0.15	0.0197	0.000000000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25615944	chr17:37008959	17	37008959	RPL23	North shore	-0.16	0.0211	0.00000000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09578155	chr11:68141470	11	68141470	LRP5	Open sea	-0.08	0.0105	0.000000000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11152412	chr15:74927688	15	74927688	EDC3	Open sea	-0.15	0.0198	0.000000000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08696727	chr10:28034797	10	28034797	MKX	Island	0.31	0.0409	0.000000000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03155159	chr16:59627519	16	59627519	-	Open sea	-0.14	0.0185	0.000000000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20596640	chr13:20436062	13	20436062	ZMYM5	North shore	-0.17	0.0224	0.000000000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15228441	chr17:78829930	17	78829930	RPTOR	North shore	-0.15	0.0198	0.000000000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03440944	chr7:45023329	7	45023329	C7orf40	North shelf	-0.13	0.0172	0.00000000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18335991	chr15:74724562	15	74724562	SEMA7A	North shore	-0.11	0.0145	0.00000000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14675361	chr13:76334583	13	76334583	LMO7	Open sea	0.17	0.0225	0.000000000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05969150	chr16:72882495	16	72882495	ZFHX3	Open sea	0.07	0.0093	0.000000000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14142087	chr9:110479859	9	110479859	-	South shore	0.1	0.0133	0.000000000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11739399	chr1:206669785	1	206669785	IKBKE	Open sea	-0.09	0.012	0.000000000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06635952	chr2:70025869	2	70025869	ANXA4	Open sea	0.11	0.0146	0.000000000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04039397	chr3:111260783	3	111260783	CD96	Open sea	-0.19	0.0253	0.000000000000053	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03957124	chr6:37016869	6	37016869	-	South shelf	-0.09	0.012	0.000000000000053	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03519879	chr14:74227499	14	74227499	C14orf43	South shore	-0.11	0.0146	0.000000000000053	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18642234	chr3:49394622	3	49394622	GPX1	North shore	-0.09	0.012	0.000000000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08666707	chr6:41456441	6	41456441	-	Open sea	-0.08	0.0107	0.00000000000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10814005	chr14:91711041	14	91711041	GPR68	Open sea	-0.21	0.028	0.00000000000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00569896	chr4:204382	4	204382	-	North shore	0.2	0.0267	0.000000000000062	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10179300	chr5:14147618	5	14147618	TRIO	South shelf	-0.15	0.02	0.000000000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16594502	chr15:40339900	15	40339900	-	Open sea	-0.1	0.0133	0.000000000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16558846	chr14:106373308	14	106373308	-	Open sea	-0.22	0.0293	0.000000000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22510139	chr1:3058822	1	3058822	PRDM16	North shore	-0.12	0.016	0.000000000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05726935	chr14:105263522	14	105263522	AKT1	South shore	-0.09	0.012	0.00000000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27262054	chr16:73067525	16	73067525	ZFHX3	Open sea	-0.11	0.0147	0.00000000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08822075	chr7:26193607	7	26193607	NFE2L3	South shore	-0.29	0.0387	0.000000000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19821297	chr19:12890029	19	12890029	-	South shore	-0.11	0.0147	0.000000000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12474798	chr10:64565772	10	64565772	ADO	Island	-0.17	0.0227	0.000000000000076	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02186444	chr17:73120977	17	73120977	ARMC7	North shelf	0.1	0.0134	0.000000000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01406381	chr19:47288263	19	47288263	SLC1A5	North shelf	-0.19	0.0254	0.000000000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07104557	chr7:1036653	7	1036653	C7orf50	North shelf	-0.13	0.0174	0.00000000000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04011474	chr2:28904455	2	28904455	-	Open sea	-0.14	0.0188	0.000000000000089	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15498134	chr1:25246854	1	25246854	RUNX3	Open sea	-0.15	0.0201	0.000000000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24709951	chr17:73033009	17	73033009	-	South shore	0.16	0.0215	0.000000000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06106428	chr11:110584327	11	110584327	ARHGAP20	South shore	0.14	0.0188	0.000000000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00911794	chr17:1962132	17	1962132	HIC1	Island	0.2	0.0269	0.000000000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18494902	chr15:40398565	15	40398565	BMF	North shelf	-0.16	0.0215	0.0000000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23230929	chr2:87883547	2	87883547	-	Open sea	0.07	0.0094	0.00000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07381806	chr19:2094327	19	2094327	MOBKL2A	North shore	-0.18	0.0242	0.00000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04881228	chr2:64557277	2	64557277	-	Open sea	-0.08	0.0108	0.00000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24908166	chr5:1268800	5	1268800	TERT	North shore	-0.16	0.0216	0.00000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04770751	chr19:7701662	19	7701662	STXBP2	Island	-0.12	0.0162	0.00000000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15022400	chr15:45028161	15	45028161	TRIM69	Open sea	-0.15	0.0203	0.00000000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08149865	chr8:21914600	8	21914600	EPB49	South shore	-0.12	0.0162	0.00000000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27280535	chr8:8746679	8	8746679	MFHAS1	North shore	-0.13	0.0176	0.00000000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21649604	chr22:39714288	22	39714288	RPL3;RNU86	North shore	-0.11	0.0149	0.00000000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02150926	chr14:106361667	14	106361667	-	Open sea	-0.1	0.0136	0.00000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05308656	chr2:235406291	2	235406291	ARL4C	Island	-0.15	0.0204	0.00000000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13066481	chr3:123372199	3	123372199	MYLK	Open sea	-0.08	0.0109	0.00000000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19325791	chr17:46560683	17	46560683	-	Open sea	0.12	0.0163	0.00000000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18956562	chr7:144149304	7	144149304	TPK1	Open sea	0.15	0.0204	0.00000000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19918734	chr11:86343931	11	86343931	ME3	Open sea	-0.12	0.0163	0.00000000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22313519	chr19:18385724	19	18385724	KIAA1683	Open sea	-0.1	0.0136	0.00000000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13127741	chr20:31331821	20	31331821	COMMD7	South shore	-0.12	0.0164	0.00000000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25270201	chrX:9984045	X	9984045	WWC3	Island	-0.24	0.0328	0.00000000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01839993	chr10:74034644	10	74034644	DDIT4	Island	-0.1	0.0137	0.00000000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02767093	chr13:99130655	13	99130655	STK24	South shelf	-0.07	0.0096	0.00000000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06360776	chr16:30545507	16	30545507	ZNF747	North shore	-0.2	0.0273	0.00000000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24287110	chr10:3824687	10	3824687	KLF6	South shore	-0.14	0.0191	0.00000000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14977938	chr14:104190829	14	104190829	ZFYVE21	North shelf	0.12	0.0164	0.00000000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11229399	chr1:228689056	1	228689056	-	Open sea	0.17	0.0233	0.00000000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23565821	chr6:33385056	6	33385056	CUTA	North shore	-0.11	0.0151	0.00000000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15396686	chr10:124897048	10	124897048	HMX3	Island	0.18	0.0246	0.00000000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25730428	chr6:29454755	6	29454755	MAS1L	Open sea	0.1	0.0137	0.00000000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22103219	chr7:101934892	7	101934892	SH2B2	North shore	-0.11	0.0151	0.00000000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25325005	chr8:145012748	8	145012748	PLEC1	North shelf	-0.14	0.0192	0.00000000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13033858	chr12:109248326	12	109248326	SSH1	North shelf	-0.13	0.0178	0.00000000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23363754	chr7:29606082	7	29606082	PRR15	Island	-0.35	0.048	0.00000000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22356527	chr5:374425	5	374425	AHRR	Island	0.09	0.0123	0.0000000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26099045	chr2:64291800	2	64291800	-	Open sea	0.15	0.0206	0.00000000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01668352	chr12:64482597	12	64482597	SRGAP1	Open sea	-0.15	0.0206	0.00000000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23198793	chr15:42694406	15	42694406	CAPN3	Open sea	0.14	0.0192	0.00000000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19798735	chr7:110730805	7	110730805	IMMP2L;LRRN3	Open sea	-0.11	0.0151	0.00000000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00008629	chr9:115093661	9	115093661	ROD1	North shore	-0.2	0.0275	0.00000000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20399616	chr12:25055967	12	25055967	BCAT1	Island	0.3	0.0412	0.00000000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25004427	chr5:326523	5	326523	AHRR	South shelf	0.15	0.0206	0.00000000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08899667	chr6:31761055	6	31761055	VARS	North shelf	0.09	0.0124	0.00000000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18882687	chr1:228275828	1	228275828	ARF1	Open sea	-0.16	0.0221	0.0000000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04535902	chr1:92947332	1	92947332	GFI1	Island	-0.29	0.04	0.00000000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08832695	chr17:46676375	17	46676375	LOC404266;HOXB6	South shore	-0.13	0.0179	0.00000000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25420507	chr19:39261921	19	39261921	LGALS7	Island	-0.13	0.018	0.00000000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05845217	chr5:4223202	5	4223202	-	Open sea	-0.16	0.0221	0.00000000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07037944	chr15:64290807	15	64290807	DAPK2	Open sea	-0.1	0.0138	0.00000000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13668129	chr19:41768075	19	41768075	HNRNPUL1	North shore	-0.06	0.0083	0.00000000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04517079	chr6:41546161	6	41546161	FOXP4	Open sea	-0.09	0.0125	0.00000000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16526047	chr1:949893	1	949893	ISG15	South shore	-0.12	0.0166	0.00000000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04368724	chr6:31760593	6	31760593	VARS	North shelf	0.14	0.0194	0.00000000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14254999	chr2:231790529	2	231790529	GPR55	Open sea	-0.14	0.0194	0.00000000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19614811	chr3:98250723	3	98250723	GPR15	Open sea	-0.31	0.043	0.00000000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09122035	chr11:319667	11	319667	-	South shore	-0.17	0.0236	0.00000000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13488013	chr17:47592680	17	47592680	-	South shelf	-0.08	0.0111	0.00000000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12741639	chr22:37678728	22	37678728	CYTH4	Open sea	-0.12	0.0167	0.00000000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07660627	chr17:35481970	17	35481970	ACACA	Open sea	0.19	0.0264	0.00000000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09848445	chr10:43601862	10	43601862	RET	South shore	-0.36	0.0501	0.00000000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07558455	chr1:62784762	1	62784762	KANK4	Island	0.28	0.039	0.00000000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01651915	chr8:55795551	8	55795551	-	Open sea	-0.18	0.0251	0.00000000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03358636	chr3:197474006	3	197474006	KIAA0226	North shelf	-0.16	0.0223	0.00000000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04761746	chr4:141177756	4	141177756	SCOC	South shelf	-0.1	0.0139	0.00000000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11927233	chr5:170816542	5	170816542	NPM1	South shore	-0.13	0.0181	0.00000000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04039799	chr11:19745484	11	19745484	NAV2	Open sea	-0.11	0.0153	0.00000000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04812351	chr4:73177995	4	73177995	ADAMTS3	Open sea	-0.12	0.0167	0.00000000000076	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25308086	chr1:2996020	1	2996020	PRDM16	North shore	-0.16	0.0223	0.00000000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02985540	chr13:46964186	13	46964186	-	South shelf	-0.1	0.014	0.00000000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18369034	chr14:52733216	14	52733216	PTGDR	North shore	-0.14	0.0195	0.00000000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22510662	chr5:36202853	5	36202853	C5orf33	Open sea	0.11	0.0154	0.0000000000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23572908	chr7:158937969	7	158937969	VIPR2	Island	0.2	0.0279	0.00000000000081	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01272202	chr5:112716899	5	112716899	MCC	Open sea	-0.13	0.0182	0.00000000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21990700	chr12:7260776	12	7260776	LOC283314;C1RL	Open sea	-0.13	0.0182	0.00000000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05635807	chr8:11422167	8	11422167	-	Island	0.28	0.0392	0.00000000000088	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03774514	chr20:22563702	20	22563702	FOXA2	Island	0.27	0.0378	0.00000000000089	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08595501	chr5:75878300	5	75878300	IQGAP2	Open sea	-0.16	0.0224	0.00000000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06762457	chr6:149806635	6	149806635	ZC3H12D	Open sea	-0.15	0.021	0.00000000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17333042	chr10:102822201	10	102822201	KAZALD1	Island	-0.08	0.0112	0.00000000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16288101	chr14:88621538	14	88621538	-	Open sea	-0.26	0.0364	0.00000000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10720997	chr1:997858	1	997858	-	North shore	0.24	0.0336	0.00000000000098	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16736826	chr1:41951512	1	41951512	EDN2	Open sea	-0.07	0.0098	0.00000000000099	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18503679	chr3:21792543	3	21792543	ZNF385D	Open sea	-0.27	0.0379	0.000000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05500734	chr7:73437649	7	73437649	-	Open sea	-0.08	0.0112	0.000000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08924321	chr11:35663067	11	35663067	-	Open sea	-0.11	0.0155	0.0000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17501395	chr6:149806331	6	149806331	ZC3H12D	Open sea	-0.19	0.0267	0.0000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.15	0.0211	0.0000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13784312	chr9:134609065	9	134609065	RAPGEF1	Open sea	-0.12	0.0169	0.0000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04813697	chr10:22920025	10	22920025	PIP4K2A	Open sea	-0.14	0.0197	0.0000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06457408	chr17:79827882	17	79827882	ARHGDIA	North shore	-0.09	0.0127	0.0000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18236066	chr12:113293823	12	113293823	RPH3A	Open sea	-0.11	0.0155	0.0000000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06369322	chr15:74607544	15	74607544	CCDC33	Open sea	-0.09	0.0127	0.0000000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19344626	chr19:16830749	19	16830749	NWD1	Open sea	-0.16	0.0226	0.0000000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20249566	chr19:16830739	19	16830739	NWD1	Open sea	-0.15	0.0212	0.0000000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17025683	chr1:173836220	1	173836220	SNORD78;ZBTB37;SNORD75;SNORD76;GAS5;SNORD77;SNORD44	North shore	-0.17	0.0241	0.0000000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13411554	chr3:53700276	3	53700276	CACNA1D	Open sea	0.27	0.0382	0.0000000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00976097	chr5:421733	5	421733	AHRR	Island	0.4	0.0566	0.0000000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09796170	chr1:156548174	1	156548174	TTC24	Open sea	-0.14	0.0198	0.0000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01083131	chr16:67877413	16	67877413	THAP11;CENPT	South shore	-0.11	0.0156	0.0000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07955474	chr16:85935556	16	85935556	IRF8	South shelf	-0.11	0.0156	0.0000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06972908	chr16:30488321	16	30488321	ITGAL	South shelf	-0.13	0.0185	0.0000000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03935116	chr12:31476565	12	31476565	FAM60A;FLJ13224	North shore	-0.11	0.0156	0.000000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22649124	chr19:39282077	19	39282077	LGALS7B	Island	-0.11	0.0156	0.000000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08884752	chr1:2162001	1	2162001	SKI	South shore	-0.12	0.0171	0.0000000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14120703	chr9:139416102	9	139416102	NOTCH1	North shore	-0.1	0.0142	0.0000000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13951797	chr16:2204381	16	2204381	TRAF7	North shore	-0.12	0.0171	0.0000000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06060868	chr5:231934	5	231934	SDHA	Open sea	-0.13	0.0185	0.0000000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10825315	chr14:81425912	14	81425912	TSHR	Open sea	0.12	0.0171	0.0000000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14656441	chr1:39500070	1	39500070	NDUFS5	Open sea	0.13	0.0186	0.0000000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09974965	chr14:106361640	14	106361640	-	Open sea	-0.1	0.0143	0.0000000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01442064	chr4:5713450	4	5713450	EVC	Island	-0.09	0.0129	0.0000000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04263702	chr7:5528266	7	5528266	FBXL18	South shore	-0.13	0.0186	0.0000000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03242819	chr10:128994432	10	128994432	DOCK1;FAM196A	Island	0.39	0.056	0.0000000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04573702	chr14:23857834	14	23857834	MYH6;MIR208A	North shore	-0.1	0.0144	0.0000000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13652493	chr2:70369050	2	70369050	-	North shore	-0.12	0.0173	0.0000000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15331301	chr6:150381200	6	150381200	-	South shelf	-0.07	0.0101	0.0000000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07764473	chrX:40037510	X	40037510	BCOR	South shore	0.14	0.0201	0.0000000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03814093	chr4:154410006	4	154410006	KIAA0922	Open sea	-0.14	0.0201	0.0000000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02743070	chr10:80834309	10	80834309	ZMIZ1	South shelf	-0.11	0.0158	0.0000000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25528646	chrX:151143302	X	151143302	GABRE	Island	0.25	0.036	0.0000000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02818189	chr1:25173236	1	25173236	-	North shore	-0.12	0.0173	0.0000000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08479476	chr2:70313163	2	70313163	PCBP1	North shore	-0.19	0.0274	0.0000000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12140977	chr8:134513309	8	134513309	ST3GAL1	Open sea	-0.08	0.0115	0.000000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01952185	chr5:134813213	5	134813213	-	Open sea	0.14	0.0202	0.0000000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01496720	chr10:3825398	10	3825398	KLF6	North shore	-0.16	0.0231	0.0000000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10827488	chr11:113953838	11	113953838	ZBTB16	Island	0.11	0.0159	0.0000000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06688763	chr7:92238207	7	92238207	CDK6	Open sea	0.2	0.0289	0.0000000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05439368	chr15:45028098	15	45028098	TRIM69	Open sea	-0.11	0.0159	0.0000000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23531049	chr15:42075277	15	42075277	MAPKBP1	Open sea	0.14	0.0202	0.0000000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05897210	chr4:36282339	4	36282339	DTHD1	Open sea	0.15	0.0217	0.0000000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17602444	chr7:644819	7	644819	PRKAR1B	North shore	-0.11	0.0159	0.0000000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18582010	chr8:131415376	8	131415376	ASAP1	Open sea	0.12	0.0173	0.0000000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10717312	chr2:241976244	2	241976244	SNED1	Island	0.13	0.0188	0.0000000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18660898	chr1:151030968	1	151030968	CDC42SE1;MLLT11	North shore	-0.16	0.0231	0.0000000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20698421	chr2:65217623	2	65217623	SLC1A4	South shore	-0.18	0.026	0.0000000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03043406	chr1:45242356	1	45242356	RPS8;SNORD38A	South shore	-0.12	0.0174	0.0000000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23222488	chr5:176755393	5	176755393	-	North shelf	0.12	0.0174	0.000000000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03474926	chr9:136023407	9	136023407	RALGDS	North shore	-0.05	0.0072	0.000000000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16151960	chr5:133890280	5	133890280	PHF15	Open sea	-0.08	0.0116	0.0000000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23950232	chr2:233323030	2	233323030	ALPI	North shore	-0.13	0.0188	0.0000000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20124610	chr13:111357885	13	111357885	CARS2	North shore	-0.09	0.0131	0.0000000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25446789	chr2:25810393	2	25810393	DTNB	Open sea	-0.09	0.0131	0.0000000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02538248	chr16:75045643	16	75045643	ZNRF1	Open sea	-0.12	0.0174	0.0000000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10255761	chr3:49210029	3	49210029	KLHDC8B	South shore	-0.11	0.016	0.0000000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11827514	chr8:143125722	8	143125722	-	Open sea	-0.23	0.0334	0.0000000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13404054	chr19:15311666	19	15311666	NOTCH3	Island	0.28	0.0407	0.0000000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02325250	chr5:131409289	5	131409289	CSF2	Open sea	-0.1	0.0145	0.0000000000062	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22674699	chr2:176987918	2	176987918	HOXD9	Island	0.36	0.0524	0.0000000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13092108	chr1:26857284	1	26857284	RPS6KA1	South shore	-0.07	0.0102	0.0000000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01951879	chr16:54315840	16	54315840	-	Island	0.15	0.0218	0.0000000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10835286	chr2:66657913	2	66657913	-	North shelf	-0.2	0.0292	0.0000000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05677062	chr12:123874707	12	123874707	SETD8	South shore	-0.11	0.016	0.0000000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01932734	chr3:50376409	3	50376409	RASSF1	North shore	-0.11	0.016	0.0000000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23621097	chr17:1962236	17	1962236	HIC1	Island	0.21	0.0306	0.0000000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20684110	chr10:64565750	10	64565750	ADO	Island	-0.13	0.019	0.0000000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22107533	chr15:45028083	15	45028083	TRIM69	Open sea	-0.1	0.0146	0.0000000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04583842	chr16:88103117	16	88103117	BANP	South shore	0.14	0.0204	0.0000000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08097614	chr19:46388787	19	46388787	IRF2BP1	Island	-0.16	0.0234	0.0000000000076	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21473814	chr19:18873268	19	18873268	CRTC1	Island	0.13	0.019	0.0000000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20902353	chr14:94425114	14	94425114	ASB2	Open sea	-0.1	0.0146	0.0000000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00207731	chr15:91416118	15	91416118	FURIN	South shore	-0.1	0.0146	0.0000000000083	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03671075	chr4:78573680	4	78573680	-	Open sea	-0.18	0.0264	0.0000000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04135110	chr5:346695	5	346695	AHRR	South shelf	0.18	0.0264	0.0000000000088	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10508317	chr17:76355146	17	76355146	SOCS3	Island	-0.18	0.0264	0.0000000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00542975	chr2:122392291	2	122392291	CLASP1	Open sea	-0.08	0.0118	0.00000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07090714	chr6:6857062	6	6857062	-	Open sea	-0.09	0.0132	0.00000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07151117	chr8:29204954	8	29204954	DUSP4	North shore	-0.12	0.0176	0.00000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10368935	chr10:18240316	10	18240316	SLC39A12	Open sea	0.17	0.025	0.00000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16708465	chr13:95933097	13	95933097	ABCC4	Open sea	-0.11	0.0162	0.00000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24399529	chr15:69373153	15	69373153	MIR548H4;TMEM84	Open sea	0.14	0.0206	0.00000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23058194	chr15:65369127	15	65369127	LOC390594	Island	0.23	0.0338	0.00000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25512107	chr17:78831167	17	78831167	RPTOR	North shore	-0.36	0.0529	0.00000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18405341	chr22:39918625	22	39918625	ATF4	South shore	-0.09	0.0132	0.00000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14429847	chr1:239550578	1	239550578	-	Island	0.14	0.0206	0.000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01594949	chr9:140197890	9	140197890	NRARP	South shore	-0.11	0.0162	0.000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01324550	chr17:46676099	17	46676099	LOC404266;HOXB6	South shore	-0.15	0.0221	0.000000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07048504	chr1:55829278	1	55829278	-	Open sea	0.11	0.0162	0.000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27484483	chr8:103249853	8	103249853	RRM2B	North shore	-0.13	0.0192	0.000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13709639	chr12:49526040	12	49526040	TUBA1B	South shore	-0.15	0.0221	0.000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06096336	chr2:231989800	2	231989800	PSMD1;HTR2B	Open sea	-0.11	0.0163	0.000000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10171489	chr6:6649662	6	6649662	LY86	Open sea	-0.17	0.0251	0.000000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15950273	chr14:103367306	14	103367306	TRAF3	Open sea	0.13	0.0192	0.000000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10959726	chr17:6917614	17	6917614	C17orf49;RNASEK	Island	-0.21	0.031	0.000000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16694480	chr1:19732786	1	19732786	CAPZB	Open sea	0.11	0.0163	0.000000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12510535	chr7:51384579	7	51384579	COBL	Island	0.3	0.0444	0.000000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16119613	chr12:127762762	12	127762762	-	North shelf	-0.11	0.0163	0.000000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23842572	chr17:17030253	17	17030253	MPRIP	Open sea	0.11	0.0163	0.000000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04387347	chr16:88537187	16	88537187	ZFPM1	Island	0.16	0.0237	0.000000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20438687	chr17:4761644	17	4761644	MINK1	Open sea	-0.11	0.0163	0.000000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15614653	chr2:129104464	2	129104464	-	South shore	-0.08	0.0119	0.000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21120249	chr9:139921971	9	139921971	C9orf139;ABCA2	North shore	-0.1	0.0149	0.000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12265950	chr11:123173709	11	123173709	-	South shore	-0.12	0.0178	0.000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11978634	chr13:43971194	13	43971194	ENOX1	Open sea	0.13	0.0193	0.000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01681367	chr16:29676071	16	29676071	SPN	Island	0.25	0.0371	0.000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05906166	chr19:16437057	19	16437057	KLF2	Island	-0.19	0.0282	0.000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19593285	chr20:32267661	20	32267661	E2F1	South shelf	-0.12	0.0178	0.000000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15636519	chr2:191894418	2	191894418	STAT4	Open sea	-0.13	0.0193	0.000000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10172979	chr14:88621579	14	88621579	-	Open sea	-0.16	0.0238	0.000000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14886849	chr14:103367489	14	103367489	TRAF3	Open sea	0.15	0.0223	0.000000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22805381	chr14:51760188	14	51760188	-	Open sea	-0.12	0.0179	0.000000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03147185	chr2:97008030	2	97008030	NCAPH	Open sea	-0.07	0.0104	0.000000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14034325	chr10:43891459	10	43891459	HNRNPF	North shore	-0.1	0.0149	0.000000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11704790	chrX:51425528	X	51425528	-	Island	0.34	0.0507	0.00000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18202080	chr2:232765247	2	232765247	-	Island	-0.12	0.0179	0.00000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08262002	chr4:16575323	4	16575323	LDB2	Open sea	-0.09	0.0134	0.00000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20017995	chr9:136216076	9	136216076	SNORD24;SNORD36B;MED22;RPL7A;SNORD36A	South shore	-0.09	0.0134	0.00000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11825621	chr10:28034792	10	28034792	MKX	Island	0.39	0.0582	0.00000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02711608	chr19:47287964	19	47287964	SLC1A5	North shelf	-0.1	0.0149	0.000000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24504361	chr12:53297987	12	53297987	KRT8	South shore	-0.1	0.015	0.000000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16290996	chr1:173835989	1	173835989	GAS5;SNORD78;SNORD76;SNORD77;SNORD44;SNORD79	North shore	-0.13	0.0195	0.000000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26995224	chr12:121974146	12	121974146	KDM2B	North shore	-0.16	0.024	0.000000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11071448	chr1:202584465	1	202584465	SYT2	Open sea	-0.12	0.018	0.000000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23829395	chr12:46796953	12	46796953	-	Open sea	-0.1	0.015	0.000000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16459265	chr7:45025080	7	45025080	C7orf40;SNORA9	North shore	-0.13	0.0195	0.000000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21854952	chr17:1961778	17	1961778	HIC1	Island	0.12	0.018	0.000000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09876440	chr3:10325981	3	10325981	GHRLOS;C3orf42	Open sea	-0.13	0.0195	0.000000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03415545	chr4:100274039	4	100274039	ADH1C	Open sea	-0.12	0.0181	0.00000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09365924	chr12:53611399	12	53611399	RARG	North shelf	-0.07	0.0105	0.00000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15908709	chr17:46676215	17	46676215	LOC404266;HOXB6	South shore	-0.13	0.0196	0.00000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06964654	chrX:139590383	X	139590383	-	Island	0.19	0.0286	0.000000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19825437	chr3:169383292	3	169383292	-	North shelf	-0.12	0.0181	0.000000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05398036	chr1:186504948	1	186504948	-	Open sea	-0.11	0.0166	0.000000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04973995	chr10:74057977	10	74057977	-	Island	-0.17	0.0256	0.000000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08441806	chr10:134599149	10	134599149	NKX6-2	Island	0.19	0.0286	0.000000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26724967	chr16:3115223	16	3115223	IL32	Open sea	-0.08	0.0121	0.000000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03188382	chr2:233245886	2	233245886	ALPP	North shore	-0.08	0.0121	0.000000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08893087	chr1:93416982	1	93416982	FAM69A	Open sea	-0.13	0.0196	0.000000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24771152	chr6:31760608	6	31760608	VARS	North shelf	0.27	0.0408	0.000000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14012925	chr7:101556907	7	101556907	CUX1	North shelf	0.08	0.0121	0.000000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23570810	chr11:315102	11	315102	IFITM1	North shore	-0.14	0.0211	0.000000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26132737	chr2:198029141	2	198029141	ANKRD44	Island	-0.16	0.0242	0.000000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19847577	chr15:29213748	15	29213748	APBA2	Open sea	0.1	0.0151	0.000000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15212295	chr17:64710687	17	64710687	PRKCA	Open sea	-0.11	0.0166	0.000000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25838968	chr1:208250847	1	208250847	PLXNA2	Open sea	-0.1	0.0151	0.000000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16556677	chr11:2722401	11	2722401	KCNQ1OT1;KCNQ1	South shore	-0.14	0.0212	0.000000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04086928	chr9:134612644	9	134612644	RAPGEF1	Open sea	-0.1	0.0151	0.00000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00360761	chr2:43398079	2	43398079	-	Island	0.16	0.0242	0.000000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11416384	chr4:37246827	4	37246827	KIAA1239	Island	0.36	0.0545	0.000000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01005506	chr10:64565768	10	64565768	ADO	Island	-0.12	0.0182	0.000000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19784428	chr19:16830746	19	16830746	NWD1	Open sea	-0.14	0.0212	0.000000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22891595	chr3:193570256	3	193570256	-	Open sea	0.1	0.0152	0.000000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22978087	chr8:24814126	8	24814126	NEFL	Island	0.21	0.0319	0.000000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04890576	chr17:73032613	17	73032613	-	South shore	0.17	0.0258	0.000000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21138542	chr6:170581502	6	170581502	-	South shore	0.1	0.0152	0.000000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19211853	chr13:79968216	13	79968216	RBM26	Open sea	-0.18	0.0273	0.000000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01554474	chr1:155107599	1	155107599	RAG1AP1	North shore	-0.13	0.0197	0.000000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00148223	chr5:957913	5	957913	-	North shore	-0.1	0.0152	0.000000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22403782	chr2:233246136	2	233246136	ALPP	Island	-0.13	0.0198	0.000000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05958351	chr16:2804731	16	2804731	SRRM2	North shore	-0.09	0.0137	0.000000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16320419	chr3:5025570	3	5025570	BHLHE40	South shore	-0.1	0.0152	0.000000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15962267	chr5:138612986	5	138612986	SNHG4;SNORA74A;MATR3	South shelf	-0.09	0.0137	0.000000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09186101	chr17:80197062	17	80197062	SLC16A3	South shore	-0.12	0.0183	0.00000000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17214023	chr2:10176748	2	10176748	-	Open sea	-0.07	0.0107	0.000000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14030904	chr6:149806732	6	149806732	ZC3H12D	Open sea	-0.11	0.0167	0.000000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13829550	chr14:74893112	14	74893112	TMEM90A	Island	0.17	0.0259	0.000000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11619216	chr17:73642080	17	73642080	LOC100130933;RECQL5	Open sea	-0.08	0.0122	0.000000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01657995	chr6:31804883	6	31804883	C6orf48;SNORD52	South shelf	-0.14	0.0213	0.000000000053	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14093127	chr2:8714417	2	8714417	-	Open sea	-0.16	0.0244	0.000000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12678834	chr11:118753662	11	118753662	CXCR5	Open sea	-0.09	0.0137	0.000000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04115307	chr14:101539612	14	101539612	-	Open sea	-0.13	0.0198	0.000000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10619342	chr15:65369005	15	65369005	LOC390594	North shore	0.15	0.0229	0.000000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04659729	chr6:31762688	6	31762688	VARS	North shore	-0.11	0.0168	0.000000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20322193	chr7:39664614	7	39664614	RALA	South shore	-0.11	0.0168	0.000000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14614490	chr9:123637816	9	123637816	PHF19	North shore	-0.07	0.0107	0.000000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16786458	chr5:149108820	5	149108820	PPARGC1B	North shore	0.14	0.0214	0.000000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00565882	chr2:38300707	2	38300707	CYP1B1	North shore	0.14	0.0214	0.00000000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09554443	chr1:167487762	1	167487762	CD247	Open sea	0.09	0.0138	0.000000000062	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08170837	chr3:72494352	3	72494352	RYBP	North shore	-0.16	0.0245	0.000000000062	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10116432	chr10:104953276	10	104953276	NT5C2	South shore	-0.11	0.0168	0.000000000062	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22146612	chr6:17715219	6	17715219	-	Open sea	-0.09	0.0138	0.000000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23220823	chr7:45041140	7	45041140	CCM2	South shore	-0.14	0.0214	0.000000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17318719	chr11:117959349	11	117959349	TMPRSS4	Open sea	-0.07	0.0107	0.000000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07941108	chr14:90741814	14	90741814	-	Open sea	-0.11	0.0168	0.000000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03433699	chr17:6916926	17	6916926	RNASEK;C17orf49	North shore	-0.12	0.0184	0.000000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16201146	chr20:19191526	20	19191526	-	North shore	-0.12	0.0184	0.000000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01447828	chr19:40919465	19	40919465	PRX	Open sea	0.1	0.0153	0.000000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12054453	chr17:57915717	17	57915717	TMEM49	Open sea	-0.15	0.023	0.000000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23510258	chr17:80840821	17	80840821	TBCD	Open sea	0.1	0.0153	0.000000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15696506	chr4:57947735	4	57947735	IGFBP7	Open sea	-0.11	0.0169	0.000000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00127167	chr5:5140029	5	5140029	ADAMTS16	Island	0.2	0.0307	0.000000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19197419	chr20:44441612	20	44441612	UBE2C	Island	-0.16	0.0245	0.00000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07891911	chr15:35598798	15	35598798	-	Open sea	-0.09	0.0138	0.000000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20864568	chr17:43391599	17	43391599	MAP3K14	North shelf	-0.08	0.0123	0.000000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13399816	chr1:68299468	1	68299468	GNG12	South shore	-0.11	0.0169	0.000000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05789250	chr6:31804306	6	31804306	C6orf48;SNORD52	South shore	-0.14	0.0215	0.000000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16382047	chr2:231790037	2	231790037	GPR55	Open sea	-0.12	0.0184	0.000000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13418576	chr9:126105738	9	126105738	-	South shelf	-0.13	0.02	0.000000000076	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25421530	chr10:97200987	10	97200987	SORBS1	Open sea	0.14	0.0215	0.000000000077	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19483007	chr3:149327651	3	149327651	WWTR1	Open sea	-0.1	0.0154	0.000000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04332373	chr4:15779642	4	15779642	CD38	North shore	0.08	0.0123	0.00000000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20451986	chr11:133928302	11	133928302	-	Open sea	0.09	0.0138	0.00000000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09479241	chr17:27052676	17	27052676	TLCD1	North shore	-0.2	0.0308	0.000000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27102350	chr17:38501677	17	38501677	RARA	Island	0.15	0.0231	0.000000000084	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09037630	chr6:31528239	6	31528239	-	Open sea	-0.11	0.0169	0.000000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05462543	chr7:155251716	7	155251716	EN2	Island	0.17	0.0262	0.000000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00073460	chr6:149806502	6	149806502	ZC3H12D	Open sea	-0.14	0.0216	0.000000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24772753	chr2:171573419	2	171573419	SP5	Island	0.22	0.0339	0.000000000088	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01071159	chr2:129492198	2	129492198	-	North shelf	0.07	0.0108	0.000000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05895711	chr8:143051905	8	143051905	-	North shelf	-0.1	0.0154	0.000000000092	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13540126	chrX:51453843	X	51453843	-	Island	0.28	0.0432	0.000000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14003265	chr9:139796499	9	139796499	TRAF2	Open sea	-0.08	0.0124	0.000000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21698310	chr17:48224718	17	48224718	PPP1R9B	North shore	-0.1	0.0155	0.000000000098	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24230340	chr2:74758080	2	74758080	HTRA2;AUP1	South shore	-0.15	0.0232	0.000000000099	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08708629	chr1:144998869	1	144998869	PDE4DIP	Open sea	-0.05	0.0077	0.0000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09279512	chr1:201252510	1	201252510	PKP1	Island	0.09	0.0139	0.0000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07992484	chr2:106724161	2	106724161	UXS1	Open sea	-0.08	0.0124	0.0000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10894991	chr1:200885736	1	200885736	-	Open sea	-0.07	0.0108	0.00000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13678973	chr1:50513870	1	50513870	ELAVL4	Island	0.21	0.0325	0.00000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03287574	chr5:1886956	5	1886956	-	Island	0.13	0.0201	0.00000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11068946	chr10:134599151	10	134599151	NKX6-2	Island	0.23	0.0356	0.00000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16401465	chr10:63809170	10	63809170	ARID5B	Open sea	-0.09	0.0139	0.00000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14741228	chr12:31476479	12	31476479	FAM60A;FLJ13224	North shore	-0.14	0.0217	0.00000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20309891	chr17:41739130	17	41739130	MEOX1	Open sea	-0.07	0.0108	0.00000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10180092	chr3:171002363	3	171002363	TNIK	Open sea	-0.13	0.0202	0.00000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00377681	chr6:37102603	6	37102603	-	Open sea	-0.07	0.0109	0.00000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24133115	chr6:166075520	6	166075520	PDE10A	Island	0.18	0.028	0.00000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00177243	chr10:18434068	10	18434068	CACNB2	South shelf	0.16	0.0248	0.00000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23186333	chr11:35161900	11	35161900	CD44	South shore	-0.17	0.0264	0.00000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03480935	chr15:67417860	15	67417860	SMAD3	Open sea	-0.1	0.0155	0.00000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19202384	chr17:79894511	17	79894511	PYCR1	North shore	-0.08	0.0124	0.00000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20379671	chr22:39320879	22	39320879	-	North shelf	-0.16	0.0248	0.00000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14037218	chr1:150522367	1	150522367	ADAMTSL4	Island	-0.13	0.0202	0.00000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24323726	chr3:111314186	3	111314186	ZBED2;CD96	Open sea	-0.09	0.014	0.00000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14602222	chr12:1025663	12	1025663	RAD52	Open sea	0.11	0.0171	0.00000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02003272	chr13:50702719	13	50702719	-	North shore	-0.16	0.0249	0.00000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26242531	chr14:104190678	14	104190678	ZFYVE21	North shelf	0.09	0.014	0.00000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17551891	chr7:1960795	7	1960795	MAD1L1	Open sea	-0.13	0.0203	0.00000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07045241	chr10:131762462	10	131762462	EBF3	Island	0.19	0.0296	0.00000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12043818	chr10:47008202	10	47008202	-	Island	0.21	0.0327	0.00000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25842285	chr10:101089972	10	101089972	CNNM1	Island	0.16	0.0249	0.00000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03234777	chr11:118095544	11	118095544	AMICA1	Open sea	-0.12	0.0187	0.00000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12535280	chr11:12399498	11	12399498	PARVA	Island	0.21	0.0327	0.00000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12729894	chr11:1774378	11	1774378	HCCA2;CTSD	North shore	-0.09	0.014	0.00000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05780139	chr17:37008512	17	37008512	RPL23	North shore	-0.16	0.0249	0.00000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06008724	chr22:45403507	22	45403507	PHF21B	Island	0.26	0.0405	0.00000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09469355	chr1:2161886	1	2161886	SKI	South shore	-0.08	0.0125	0.00000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04761231	chr9:127623571	9	127623571	RPL35	Island	-0.08	0.0125	0.00000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01243823	chr16:50732212	16	50732212	NOD2	Open sea	-0.12	0.0187	0.00000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08262220	chr1:2995506	1	2995506	PRDM16	North shore	-0.11	0.0172	0.00000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21599324	chr6:34074282	6	34074282	GRM4	Open sea	-0.05	0.0078	0.00000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02787737	chr11:133928346	11	133928346	-	Open sea	0.11	0.0172	0.00000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22950598	chr12:56139862	12	56139862	GDF11	South shelf	-0.11	0.0172	0.00000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08170227	chr14:69422517	14	69422517	ACTN1	Open sea	-0.09	0.0141	0.00000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04325591	chr16:74806009	16	74806009	FA2H	North shelf	0.06	0.0094	0.00000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02440668	chr17:77721989	17	77721989	-	Island	0.35	0.0547	0.00000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04198308	chr22:48971959	22	48971959	FAM19A5	Island	0.34	0.0532	0.00000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07572052	chr1:149821168	1	149821168	HIST2H2AA4;HIST2H2AA3	North shore	-0.17	0.0266	0.00000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10678215	chr5:143191565	5	143191565	HMHB1	Open sea	0.11	0.0172	0.00000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16554099	chr6:7053734	6	7053734	-	South shore	-0.1	0.0157	0.00000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22562942	chr8:24772309	8	24772309	NEFM	Island	0.18	0.0282	0.00000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11902728	chr19:35786580	19	35786580	MAG	Island	0.08	0.0125	0.00000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04899175	chr12:117798748	12	117798748	NOS1	Island	0.22	0.0345	0.00000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26905258	chr13:77898407	13	77898407	MYCBP2	North shelf	-0.08	0.0125	0.00000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12170787	chr19:1130965	19	1130965	SBNO2	Open sea	-0.05	0.0078	0.00000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09349128	chr22:50327986	22	50327986	-	North shore	-0.08	0.0125	0.00000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10951873	chr1:25254746	1	25254746	RUNX3	North shore	-0.12	0.0188	0.00000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24681499	chr1:42706997	1	42706997	FOXJ3	Open sea	0.06	0.0094	0.00000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26856289	chr1:24307516	1	24307516	SFRS13A	South shore	-0.08	0.0126	0.00000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09931909	chr6:74160206	6	74160206	C6orf150	North shore	-0.19	0.0298	0.00000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00397673	chr18:56940418	18	56940418	RAX	Island	0.1	0.0157	0.00000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01588224	chr1:153950867	1	153950867	JTB	South shore	-0.09	0.0141	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14473102	chr2:176994448	2	176994448	HOXD8	Island	0.3	0.0472	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18561976	chr2:204801508	2	204801508	ICOS	Open sea	-0.16	0.0252	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03929796	chr3:52231840	3	52231840	ALAS1	North shore	-0.14	0.022	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22573696	chr6:33216663	6	33216663	-	Island	-0.16	0.0252	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01614020	chr8:24814137	8	24814137	NEFL	Island	0.25	0.0393	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24931658	chr8:21914524	8	21914524	EPB49	Island	-0.08	0.0126	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13985437	chr11:76381044	11	76381044	LRRC32	North shore	-0.1	0.0157	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05668853	chr17:27044169	17	27044169	RAB34	Island	-0.1	0.0157	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18708252	chr22:39545030	22	39545030	CBX7	North shelf	-0.1	0.0157	0.0000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20435896	chr4:40632723	4	40632723	RBM47	South shore	0.08	0.0126	0.00000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07632771	chr7:148611823	7	148611823	-	Open sea	-0.08	0.0126	0.00000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25189564	chr7:158938051	7	158938051	VIPR2	Island	0.22	0.0346	0.00000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14548802	chr9:137675380	9	137675380	COL5A1	Open sea	0.13	0.0205	0.00000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03224013	chr14:106382726	14	106382726	KIAA0125	Open sea	-0.15	0.0236	0.00000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08549806	chr16:49868530	16	49868530	-	North shelf	-0.12	0.0189	0.00000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26352795	chr1:9354739	1	9354739	SPSB1	Open sea	-0.11	0.0173	0.00000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16023545	chr2:237076726	2	237076726	GBX2	Island	0.21	0.0331	0.00000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11429111	chr5:134813329	5	134813329	-	Open sea	0.12	0.0189	0.00000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16219322	chr5:399012	5	399012	AHRR	Open sea	-0.12	0.0189	0.00000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00911776	chr7:130682239	7	130682239	FLJ43663	Open sea	-0.12	0.0189	0.00000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15393221	chr19:40919485	19	40919485	PRX	Open sea	0.11	0.0173	0.00000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18092028	chr20:59827212	20	59827212	CDH4	Island	0.28	0.0441	0.00000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26189283	chr1:155109378	1	155109378	RAG1AP1	South shore	-0.13	0.0205	0.00000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24497361	chr11:3858493	11	3858493	RHOG	North shelf	-0.11	0.0174	0.00000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12072964	chr18:7117321	18	7117321	LAMA1	Island	0.34	0.0536	0.00000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10991514	chrX:125300111	X	125300111	DCAF12L2	Island	0.23	0.0363	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22242842	chr2:85167149	2	85167149	-	Open sea	-0.11	0.0174	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24603464	chr2:238395852	2	238395852	MLPH	Island	0.22	0.0347	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17037282	chr5:50678928	5	50678928	ISL1	Island	0.15	0.0237	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25368647	chr5:176736591	5	176736591	MXD3	North shore	-0.11	0.0174	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13001142	chr6:147528521	6	147528521	STXBP5	South shelf	0.21	0.0332	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18900812	chr6:36646127	6	36646127	CDKN1A	North shore	-0.18	0.0284	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25325512	chr6:37142220	6	37142220	PIM1	South shelf	-0.11	0.0174	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25491122	chr13:67801551	13	67801551	PCDH9	North shelf	0.16	0.0253	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12946660	chr19:41771873	19	41771873	HNRNPUL1	South shore	-0.15	0.0237	0.00000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06012804	chr3:193849318	3	193849318	-	North shelf	-0.09	0.0142	0.00000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26847866	chr8:27492077	8	27492077	SCARA3	South shore	-0.06	0.0095	0.00000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21916461	chr11:68148079	11	68148079	LRP5	Open sea	-0.14	0.0221	0.00000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27260927	chrX:99986436	X	99986436	SYTL4	Island	0.14	0.0221	0.00000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26467528	chr6:31632248	6	31632248	BAT4;CSNK2B	North shore	-0.09	0.0142	0.00000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06868100	chr7:29606349	7	29606349	PRR15	South shore	-0.21	0.0332	0.00000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27414481	chr11:6342510	11	6342510	PRKCDBP	South shore	-0.12	0.019	0.00000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03489965	chr15:65368982	15	65368982	LOC390594	North shore	0.15	0.0237	0.00000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19744173	chr2:112913178	2	112913178	FBLN7	North shelf	0.08	0.0127	0.00000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10182317	chr6:123317487	6	123317487	CLVS2	Island	0.19	0.0301	0.00000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04834097	chr7:63774078	7	63774078	LOC728927	Open sea	-0.09	0.0143	0.00000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00893603	chr13:26587011	13	26587011	ATP8A2	South shore	-0.18	0.0285	0.00000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04945608	chr20:43118723	20	43118723	TTPAL	Open sea	-0.11	0.0174	0.00000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06304097	chr10:133109867	10	133109867	TCERG1L	Island	0.29	0.046	0.00000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15653173	chr13:112723034	13	112723034	SOX1	Island	0.18	0.0286	0.00000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16794579	chr16:17562419	16	17562419	XYLT1	Open sea	-0.09	0.0143	0.00000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11832534	chr1:3563998	1	3563998	WDR8	North shelf	0.13	0.0206	0.0000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16037711	chr1:59280841	1	59280841	-	North shore	-0.09	0.0143	0.0000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27453606	chr17:38498098	17	38498098	RARA	Island	0.14	0.0222	0.0000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07452776	chr14:91716835	14	91716835	GPR68	North shelf	-0.08	0.0127	0.00000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05156137	chr21:35898975	21	35898975	RCAN1	Open sea	0.13	0.0207	0.00000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05689413	chr6:41885417	6	41885417	MED20	North shelf	-0.1	0.0159	0.00000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14796406	chr7:80547689	7	80547689	SEMA3C	North shore	-0.19	0.0302	0.00000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10403394	chr15:63349192	15	63349192	TPM1	Open sea	0.18	0.0286	0.00000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04232972	chr16:30671644	16	30671644	-	South shore	-0.12	0.0191	0.00000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03451670	chr2:236579469	2	236579469	AGAP1	Island	0.23	0.0366	0.00000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10071824	chr13:28366759	13	28366759	GSX1	Island	0.17	0.0271	0.00000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22098115	chr2:131721768	2	131721768	ARHGEF4	Island	0.31	0.0494	0.00000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06357748	chr12:1025529	12	1025529	RAD52	Open sea	0.13	0.0207	0.00000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20454518	chr12:133135463	12	133135463	FBRSL1	Island	0.12	0.0191	0.00000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27393010	chr7:121940216	7	121940216	-	Island	0.21	0.0335	0.00000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08331398	chr6:32808918	6	32808918	PSMB8	North shelf	-0.11	0.0175	0.00000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11746684	chr8:11057265	8	11057265	XKR6	North shore	-0.12	0.0191	0.00000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23003085	chr11:64084321	11	64084321	PRDX5;TRMT112	North shore	-0.12	0.0191	0.00000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16937168	chr2:241936844	2	241936844	SNED1	North shore	-0.12	0.0192	0.00000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07520810	chr10:63809149	10	63809149	ARID5B	Open sea	-0.09	0.0144	0.00000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10362475	chr11:70507825	11	70507825	SHANK2	North shore	-0.15	0.0239	0.00000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07573872	chr19:1126342	19	1126342	SBNO2	South shelf	-0.1	0.016	0.00000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00313914	chr1:201618901	1	201618901	NAV1	Island	-0.23	0.0367	0.00000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07996594	chr1:25257505	1	25257505	RUNX3	Island	-0.23	0.0367	0.00000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21356710	chr2:24234017	2	24234017	MFSD2B	South shore	0.11	0.0176	0.00000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24911837	chr7:65227864	7	65227864	CCT6P1	North shore	-0.09	0.0144	0.00000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13483196	chr9:15156120	9	15156120	-	Open sea	-0.09	0.0144	0.00000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01790523	chr2:167229656	2	167229656	SCN9A	North shelf	-0.11	0.0176	0.00000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16578883	chr5:58421559	5	58421559	PDE4D	Open sea	-0.11	0.0176	0.00000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22900607	chr19:2546938	19	2546938	GNG7	Island	-0.15	0.024	0.00000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22173632	chr4:85878805	4	85878805	WDFY3	Open sea	-0.11	0.0176	0.0000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23641852	chr19:31841161	19	31841161	TSHZ3	Island	0.26	0.0416	0.0000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25975712	chr22:48971051	22	48971051	FAM19A5	Island	0.18	0.0288	0.0000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15380744	chr4:15964812	4	15964812	FGFBP2	Open sea	-0.12	0.0192	0.00000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04351258	chr16:30569043	16	30569043	ZNF764	North shore	-0.13	0.0208	0.00000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17290213	chr11:65344355	11	65344355	EHBP1L1	South shore	-0.07	0.0112	0.00000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21227253	chr14:86050984	14	86050984	FLRT2	Open sea	-0.07	0.0112	0.00000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05492306	chr19:45927594	19	45927594	ERCC1	South shore	-0.09	0.0144	0.00000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11824827	chr16:31075547	16	31075547	ZNF668	Island	0.1	0.016	0.00000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06484123	chr19:53107200	19	53107200	-	South shelf	0.14	0.0224	0.00000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27449150	chr1:118197326	1	118197326	-	Open sea	-0.11	0.0177	0.00000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12539124	chr6:21948636	6	21948636	FLJ22536	Open sea	-0.18	0.0289	0.00000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01765174	chr9:100880960	9	100880960	TRIM14	North shore	-0.11	0.0177	0.00000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01971407	chr11:313624	11	313624	IFITM1	North shelf	-0.08	0.0128	0.00000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13119578	chr11:65196696	11	65196696	-	Open sea	-0.14	0.0225	0.00000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05487507	chr17:46671861	17	46671861	LOC404266;HOXB5	North shore	-0.11	0.0177	0.00000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04614290	chr19:2327696	19	2327696	LSM7;SPPL2B	North shore	-0.13	0.0209	0.00000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18241337	chr3:156271892	3	156271892	SSR3	North shore	-0.09	0.0145	0.00000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00699945	chr10:134600651	10	134600651	NKX6-2	Island	0.26	0.0418	0.00000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19309676	chr19:50191439	19	50191439	C19orf76;PRMT1	Island	-0.09	0.0145	0.00000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19821872	chr2:240667798	2	240667798	-	Open sea	-0.11	0.0177	0.00000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02056682	chr16:54965084	16	54965084	IRX5	Island	0.34	0.0546	0.00000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11801110	chr22:50356763	22	50356763	PIM3	Island	-0.09	0.0145	0.00000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25998745	chr8:142028625	8	142028625	-	Open sea	-0.11	0.0177	0.0000000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19089328	chr11:71210210	11	71210210	NADSYN1	Open sea	0.13	0.0209	0.00000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21081878	chr21:38334730	21	38334730	HLCS	North shelf	0.13	0.0209	0.00000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25722983	chr1:36840028	1	36840028	STK40	Open sea	-0.09	0.0145	0.00000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24139443	chr17:74131549	17	74131549	-	North shelf	-0.12	0.0193	0.00000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25104105	chr1:14925198	1	14925198	KIAA1026	Island	0.2	0.0322	0.00000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24924577	chr15:90735148	15	90735148	SEMA4B	Open sea	0.1	0.0161	0.00000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02632200	chr10:46971658	10	46971658	SYT15	South shore	-0.06	0.0097	0.00000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19030554	chr16:1822289	16	1822289	NME3;MRPS34;EME2	Island	-0.13	0.021	0.00000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21201401	chr20:62367884	20	62367884	LIME1	North shore	0.14	0.0226	0.00000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01832549	chr1:19774989	1	19774989	CAPZB	Open sea	-0.1	0.0161	0.00000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22040631	chr2:129153820	2	129153820	-	Open sea	-0.13	0.021	0.00000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00063111	chr3:39448952	3	39448952	SNORA6;RPSA	South shore	-0.15	0.0242	0.00000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18697636	chr5:524503	5	524503	SLC9A3	Island	0.27	0.0436	0.00000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07960624	chr8:119208486	8	119208486	SAMD12	Open sea	-0.12	0.0194	0.00000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26703507	chr2:113404661	2	113404661	SLC20A1	South shore	-0.11	0.0178	0.00000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26196424	chr14:58615960	14	58615960	C14orf37	North shelf	-0.12	0.0194	0.00000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03746015	chr16:11141000	16	11141000	CLEC16A	Open sea	-0.18	0.0291	0.00000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13985485	chr1:239550283	1	239550283	-	Island	0.28	0.0453	0.00000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08803263	chr16:80966302	16	80966302	-	Island	0.23	0.0372	0.00000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20329047	chr8:145514383	8	145514383	BOP1;HSF1	North shore	-0.1	0.0162	0.00000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13832201	chr17:19282521	17	19282521	MAPK7	Island	-0.1	0.0162	0.00000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02081733	chr15:68120412	15	68120412	LBXCOR1	Island	0.11	0.0178	0.00000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15857661	chr10:104196243	10	104196243	MIR146B	South shelf	-0.12	0.0195	0.0000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14243623	chr9:90341158	9	90341158	CTSL1	Island	0.21	0.0341	0.00000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23219570	chr12:4488893	12	4488893	FGF23	Open sea	0.12	0.0195	0.00000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02959759	chr12:2801584	12	2801584	CACNA1C	South shore	0.15	0.0243	0.00000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08425678	chr1:14029478	1	14029478	PRDM2	South shelf	-0.1	0.0162	0.00000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04837025	chr1:236228744	1	236228744	NID1	Island	0.24	0.039	0.00000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16585333	chr1:223302861	1	223302861	TLR5	Open sea	0.16	0.026	0.00000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04179952	chr1:201619295	1	201619295	NAV1	Island	-0.26	0.0422	0.00000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18422587	chr7:3134670	7	3134670	-	Open sea	0.21	0.0341	0.00000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13834112	chr15:90361639	15	90361639	-	South shelf	0.11	0.0179	0.00000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01765406	chr2:129231478	2	129231478	-	South shelf	-0.09	0.0146	0.00000000076	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09442654	chr8:53477881	8	53477881	FAM150A	Island	0.23	0.0374	0.00000000076	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01758512	chr6:96463902	6	96463902	FUT9	Island	0.16	0.026	0.00000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03293015	chr8:98881351	8	98881351	MATN2	Island	0.16	0.026	0.00000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12818557	chr8:89340139	8	89340139	MMP16	Island	0.16	0.026	0.00000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04982781	chr22:39714193	22	39714193	RPL3;RNU86	North shore	-0.1	0.0163	0.00000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20405017	chr17:50235393	17	50235393	CA10	Island	0.15	0.0244	0.0000000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26364091	chr22:41633219	22	41633219	CHADL	North shore	-0.06	0.0098	0.0000000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07945582	chr7:26206579	7	26206579	NFE2L3	Open sea	-0.11	0.0179	0.00000000081	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04710402	chr7:87257074	7	87257074	RUNDC3B;ABCB1	Island	0.27	0.044	0.00000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02935338	chr18:25755847	18	25755847	CDH2	Island	0.12	0.0195	0.00000000083	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10675138	chr6:166075504	6	166075504	PDE10A	Island	0.16	0.0261	0.00000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08883485	chr1:201619787	1	201619787	NAV1	Island	-0.13	0.0212	0.00000000088	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01098955	chr14:106322163	14	106322163	-	South shore	-0.16	0.0261	0.0000000009	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25508605	chr15:92706125	15	92706125	SLCO3A1	Open sea	0.22	0.0359	0.0000000009	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19696491	chr15:78857124	15	78857124	CHRNA5	North shore	0.13	0.0212	0.00000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19329121	chr7:95226035	7	95226035	PDK4	Island	0.14	0.0229	0.00000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03629943	chr10:101089149	10	101089149	CNNM1	Island	0.16	0.0261	0.00000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06827562	chr3:125932279	3	125932279	-	Island	0.13	0.0212	0.00000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07708487	chr16:89387014	16	89387014	ANKRD11	Open sea	-0.09	0.0147	0.00000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00777627	chr6:166075755	6	166075755	PDE10A	Island	0.17	0.0278	0.00000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03530754	chr12:128751460	12	128751460	TMEM132C	Island	0.17	0.0278	0.00000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23586595	chr4:84034390	4	84034390	PLAC8	South shelf	0.17	0.0278	0.00000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22690188	chrX:64627670	X	64627670	-	Island	0.24	0.0393	0.00000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14488952	chr6:17394312	6	17394312	CAP2	Open sea	0.2	0.0327	0.000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17567838	chr6:33167488	6	33167488	SLC39A7;RXRB	North shore	-0.08	0.0131	0.000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00285343	chr7:41733356	7	41733356	LOC285954;INHBA	Open sea	-0.12	0.0196	0.000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04008901	chr7:82072779	7	82072779	CACNA2D1	Island	0.17	0.0278	0.000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17451609	chr8:25901869	8	25901869	EBF2	Island	0.13	0.0213	0.000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08719869	chr9:8857486	9	8857486	PTPRD	Island	0.16	0.0262	0.000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00496272	chr16:67877232	16	67877232	CENPT;THAP11	South shore	-0.1	0.0164	0.000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09425279	chr16:31188401	16	31188401	-	North shelf	0.08	0.0131	0.000000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15930380	chr1:67399983	1	67399983	MIER1	South shelf	0.13	0.0213	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27573991	chr1:247712512	1	247712512	C1orf150	Open sea	-0.26	0.0427	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22672060	chr4:156464550	4	156464550	-	Open sea	-0.09	0.0148	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01927745	chr5:72677723	5	72677723	-	Island	0.18	0.0295	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12828729	chr5:134823969	5	134823969	-	North shore	0.09	0.0148	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22052143	chr5:78067856	5	78067856	-	Open sea	0.1	0.0164	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19142553	chr7:26236069	7	26236069	HNRNPA2B1	North shelf	-0.08	0.0131	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07058086	chr8:29120186	8	29120186	KIF13B	Island	0.18	0.0295	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02039267	chr10:118894069	10	118894069	VAX1	Island	0.18	0.0295	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11700584	chr14:50088544	14	50088544	RPL36AL;MGAT2	South shore	-0.12	0.0197	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00574412	chr17:27892866	17	27892866	ABHD15	North shore	-0.07	0.0115	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04597545	chr19:800229	19	800229	PTBP1	South shore	-0.06	0.0098	0.0000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00960552	chr1:116380946	1	116380946	NHLH2	Island	0.11	0.0181	0.0000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18174402	chr2:27441263	2	27441263	CAD	South shore	-0.11	0.0181	0.0000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22290284	chr3:49726443	3	49726443	MST1;RNF123	North shore	-0.08	0.0132	0.0000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00689360	chr4:100273995	4	100273995	ADH1C	Open sea	-0.13	0.0214	0.0000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00007076	chr8:67342600	8	67342600	RRS1	North shore	-0.11	0.0181	0.0000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18458509	chr11:2920189	11	2920189	SLC22A18AS;SLC22A18	North shelf	-0.09	0.0148	0.0000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02511156	chr12:72666264	12	72666264	LOC283392;TRHDE	Island	0.29	0.0477	0.0000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10592478	chr12:53612641	12	53612641	RARG	North shore	-0.14	0.023	0.0000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26517714	chr5:170736245	5	170736245	TLX3	Island	0.16	0.0264	0.0000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23636802	chr6:32054441	6	32054441	TNXB	North shore	-0.09	0.0148	0.0000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27618240	chr7:20824770	7	20824770	SP8	Island	0.21	0.0346	0.0000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07192048	chr11:70560211	11	70560211	SHANK2	North shelf	-0.14	0.0231	0.0000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09546258	chr11:68444995	11	68444995	-	Open sea	-0.06	0.0099	0.0000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02013841	chr13:49159767	13	49159767	-	Open sea	-0.16	0.0264	0.0000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24222546	chr15:74501771	15	74501771	STRA6	Open sea	-0.1	0.0165	0.0000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05644767	chr16:31366118	16	31366118	ITGAX	Open sea	-0.08	0.0132	0.0000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00214171	chr17:73642991	17	73642991	RECQL5;LOC100130933	Open sea	-0.07	0.0115	0.0000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15082028	chr1:19043507	1	19043507	PAX7	Island	0.22	0.0363	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11546137	chr2:176972563	2	176972563	HOXD11	North shore	0.23	0.038	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19906672	chr4:6918868	4	6918868	TBC1D14	Open sea	-0.12	0.0198	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06933384	chr5:74808293	5	74808293	COL4A3BP;POLK	South shore	-0.14	0.0231	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16608498	chr5:158612132	5	158612132	RNF145	Open sea	-0.09	0.0149	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18951352	chr6:149806077	6	149806077	ZC3H12D	Open sea	-0.15	0.0248	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08492619	chr13:88324193	13	88324193	SLITRK5	Island	0.16	0.0264	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24361265	chr15:44068668	15	44068668	ELL3	Island	-0.19	0.0314	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27070951	chr15:92532867	15	92532867	SLCO3A1	Open sea	-0.12	0.0198	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13909076	chr18:77468488	18	77468488	CTDP1	South shelf	-0.14	0.0231	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22455914	chr18:7116977	18	7116977	LAMA1	Island	0.29	0.0479	0.0000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14516385	chrX:37003934	X	37003934	-	Island	0.31	0.0513	0.0000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04287574	chr1:201619622	1	201619622	NAV1	Island	-0.25	0.0414	0.0000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18990050	chr7:1163642	7	1163642	C7orf50	Open sea	-0.17	0.0281	0.0000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09559189	chr8:25898412	8	25898412	EBF2	North shore	0.13	0.0215	0.0000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19867649	chr11:12030838	11	12030838	DKK3	Island	0.24	0.0397	0.0000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06934523	chr14:70077930	14	70077930	KIAA0247	North shore	-0.09	0.0149	0.0000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21067023	chr18:501513	18	501513	COLEC12	South shore	-0.16	0.0265	0.0000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23484392	chr18:66465334	18	66465334	CCDC102B	Open sea	-0.11	0.0182	0.0000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02639359	chr19:17862017	19	17862017	FCHO1	South shelf	-0.1	0.0165	0.0000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09557991	chr1:12227927	1	12227927	TNFRSF1B	South shore	-0.13	0.0215	0.0000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20661303	chr1:226129561	1	226129561	LEFTY2	South shore	-0.06	0.0099	0.0000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13256912	chr3:11211081	3	11211081	HRH1	Open sea	-0.1	0.0166	0.0000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26114043	chr4:128544375	4	128544375	-	Island	0.21	0.0348	0.0000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16924337	chr6:153452724	6	153452724	RGS17	Island	0.16	0.0265	0.0000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27182159	chr6:33241226	6	33241226	RPS18	South shore	-0.08	0.0133	0.0000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07954423	chr9:130741881	9	130741881	FAM102A	North shore	-0.12	0.0199	0.0000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16255816	chr17:39889811	17	39889811	HAP1	North shore	-0.08	0.0133	0.0000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17368760	chr20:23029287	20	23029287	THBD	Island	0.27	0.0447	0.0000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04042861	chr2:231989824	2	231989824	HTR2B;PSMD1	Open sea	-0.09	0.0149	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04389058	chr3:57041402	3	57041402	ARHGEF3	Open sea	-0.1	0.0166	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26203136	chr7:739057	7	739057	PRKAR1B	Open sea	-0.09	0.0149	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24540678	chr8:28258603	8	28258603	-	North shore	-0.13	0.0216	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13442016	chr10:104196339	10	104196339	MIR146B	South shelf	-0.1	0.0166	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25597390	chr10:5333615	10	5333615	-	Open sea	-0.16	0.0266	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03843000	chr12:114846968	12	114846968	TBX5	Island	0.15	0.0249	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24665265	chr15:70852115	15	70852115	-	Open sea	0.09	0.0149	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03792876	chr16:73243	16	73243	-	South shore	-0.11	0.0183	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14184886	chr19:46386226	19	46386226	-	Island	-0.1	0.0166	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16903811	chr22:21316245	22	21316245	-	North shelf	-0.12	0.0199	0.0000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10869581	chrX:102000905	X	102000905	BHLHB9	Island	0.18	0.0299	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26788216	chr2:102844110	2	102844110	IL1RL2	Open sea	-0.12	0.02	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02010196	chr5:146889275	5	146889275	-	Island	0.22	0.0366	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04992127	chr5:2751854	5	2751854	IRX2;C5orf38	Island	0.27	0.0449	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05987787	chr6:158448508	6	158448508	SYNJ2	Open sea	0.13	0.0216	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20673829	chr7:158938060	7	158938060	VIPR2	Island	0.18	0.0299	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21171320	chr9:73178360	9	73178360	TRPM3	Open sea	-0.08	0.0133	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26276120	chr12:6977747	12	6977747	TPI1	South shore	-0.13	0.0216	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20585530	chr14:60975912	14	60975912	SIX6	Island	0.14	0.0233	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25143652	chr20:62168670	20	62168670	PTK6	Island	-0.07	0.0116	0.0000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09900893	chr1:26865376	1	26865376	RPS6KA1	Open sea	-0.09	0.015	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20823695	chr1:2345410	1	2345410	PEX10	North shore	-0.07	0.0117	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25067242	chr1:115881259	1	115881259	NGF	Island	0.19	0.0316	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24741609	chr1:54122060	1	54122060	GLIS1	Open sea	-0.08	0.0133	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22117188	chr3:52347940	3	52347940	-	Open sea	-0.07	0.0117	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19419291	chr5:95295965	5	95295965	ELL2	North shore	-0.15	0.025	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10317175	chr10:25247855	10	25247855	-	Open sea	-0.09	0.015	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19873536	chr10:116475283	10	116475283	-	Open sea	-0.14	0.0233	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14428590	chr15:40076065	15	40076065	FSIP1	South shore	-0.08	0.0133	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17232357	chr15:67012832	15	67012832	SMAD6	Open sea	-0.09	0.015	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12322877	chr17:79963213	17	79963213	ASPSCR1	South shore	-0.13	0.0216	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05080154	chr18:76739409	18	76739409	SALL3	Island	0.27	0.045	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22549408	chr18:57566300	18	57566300	PMAIP1	North shore	-0.13	0.0216	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15787712	chr19:13948243	19	13948243	MIR24-2;MIR23A;MIR27A	South shelf	-0.07	0.0117	0.0000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14700531	chr8:733412	8	733412	-	North shelf	0.12	0.02	0.000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17028039	chr10:123357695	10	123357695	FGFR2	Island	0.13	0.0217	0.000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25628989	chr11:57093345	11	57093345	TNKS1BP1	South shore	-0.14	0.0233	0.000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06223834	chr16:4103161	16	4103161	ADCY9	Open sea	-0.22	0.0367	0.000000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01693305	chr1:19813311	1	19813311	CAPZB	South shore	-0.13	0.0217	0.0000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09496748	chr2:198029215	2	198029215	ANKRD44	Island	-0.12	0.02	0.0000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18314424	chr4:184718605	4	184718605	-	Island	0.25	0.0417	0.0000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18688062	chr6:31146471	6	31146471	PSORS1C3	North shore	-0.11	0.0184	0.0000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10700424	chr11:134201952	11	134201952	GLB1L2	Island	0.26	0.0434	0.0000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18618815	chr17:48275324	17	48275324	COL1A1	North shore	-0.1	0.0167	0.0000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21380183	chr20:50312632	20	50312632	ATP9A	Open sea	-0.28	0.0467	0.0000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00718129	chrX:10084289	X	10084289	WWC3	North shore	-0.12	0.0201	0.0000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09610569	chrX:144899592	X	144899592	SLITRK2	Island	0.24	0.0401	0.0000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00928816	chr10:63809098	10	63809098	ARID5B	Open sea	-0.09	0.015	0.0000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07057831	chr12:131323042	12	131323042	STX2	North shore	-0.07	0.0117	0.0000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06791426	chr12:133135361	12	133135361	FBRSL1	Island	0.11	0.0184	0.0000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04956244	chr17:38511592	17	38511592	RARA	Open sea	0.07	0.0117	0.0000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07967717	chr1:24229682	1	24229682	CNR2	South shore	0.09	0.0151	0.0000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17389813	chr11:122060265	11	122060265	LOC399959	Open sea	-0.18	0.0301	0.0000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21746120	chr11:68142234	11	68142234	LRP5	Open sea	-0.07	0.0117	0.0000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18026626	chr15:78286614	15	78286614	LOC91450	Open sea	-0.06	0.01	0.0000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19022697	chr1:55247140	1	55247140	TTC22	Island	-0.16	0.0268	0.0000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27177841	chr1:213125950	1	213125950	VASH2	South shore	-0.1	0.0168	0.0000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17036062	chrX:25034037	X	25034037	ARX	Island	0.18	0.0302	0.0000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25298754	chr3:111314102	3	111314102	ZBED2;CD96	Open sea	-0.09	0.0151	0.0000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17745339	chr5:176755199	5	176755199	-	North shelf	0.13	0.0218	0.0000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08125960	chr12:107713416	12	107713416	BTBD11	Island	0.19	0.0319	0.0000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11094248	chr17:38494580	17	38494580	RARA	North shelf	-0.1	0.0168	0.0000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14269109	chr17:78513167	17	78513167	-	Open sea	0.13	0.0218	0.0000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04227922	chr2:119615496	2	119615496	-	Island	0.12	0.0202	0.0000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21307484	chr22:37546220	22	37546220	IL2RB	Open sea	-0.06	0.0101	0.0000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00256485	chr5:1494980	5	1494980	LPCAT1	Island	-0.05	0.0084	0.0000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06672250	chr8:21914593	8	21914593	EPB49	South shore	-0.08	0.0134	0.0000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15173134	chr10:119000638	10	119000638	SLC18A2	Island	0.16	0.0269	0.0000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02161701	chr15:90199179	15	90199179	KIF7	South shore	0.13	0.0219	0.0000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11739148	chr15:31622112	15	31622112	KLF13	South shore	-0.08	0.0134	0.0000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13389502	chr17:1961440	17	1961440	HIC1	Island	0.1	0.0168	0.0000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17585528	chr3:187988060	3	187988060	LPP	Open sea	-0.19	0.032	0.0000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20188739	chr8:67834756	8	67834756	SNORD87;SNHG6	North shelf	-0.08	0.0135	0.0000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21828716	chr14:23857953	14	23857953	MYH6;MIR208A	North shore	-0.07	0.0118	0.0000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03603381	chr15:38857474	15	38857474	RASGRP1	Island	-0.06	0.0101	0.0000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09282085	chr22:39713086	22	39713086	RPL3;RNU86	North shelf	-0.07	0.0118	0.0000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10012530	chr2:129073706	2	129073706	HS6ST1	North shore	-0.08	0.0135	0.0000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04137490	chr8:25176732	8	25176732	DOCK5	Open sea	0.2	0.0337	0.0000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20547777	chr8:119086580	8	119086580	EXT1	Open sea	-0.14	0.0236	0.0000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03531326	chr19:39443344	19	39443344	FBXO17	South shelf	0.06	0.0101	0.0000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24144083	chr3:36805814	3	36805814	-	North shore	0.23	0.0388	0.000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06822816	chr8:120220882	8	120220882	MAL2	Island	0.22	0.0371	0.000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16389209	chr10:63809121	10	63809121	ARID5B	Open sea	-0.08	0.0135	0.000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06697407	chr12:3305394	12	3305394	TSPAN9	North shelf	0.2	0.0337	0.000000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15123984	chr5:174151634	5	174151634	MSX2	Island	0.18	0.0304	0.0000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08782337	chr7:193262	7	193262	FAM20C	Island	0.2	0.0337	0.0000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13126206	chr8:22930189	8	22930189	-	South shelf	-0.06	0.0101	0.0000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00240113	chrX:136648241	X	136648241	ZIC3	Island	0.18	0.0304	0.0000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01910639	chr1:153507779	1	153507779	S100A6	North shore	-0.08	0.0135	0.0000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04859706	chr4:30721997	4	30721997	PCDH7	Island	0.26	0.0439	0.0000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10592592	chr10:74034663	10	74034663	DDIT4	Island	-0.1	0.0169	0.0000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07525202	chr17:30591850	17	30591850	RHBDL3	North shore	-0.11	0.0186	0.0000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27593384	chr18:25755608	18	25755608	CDH2	Island	0.32	0.0541	0.0000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16029875	chr1:204320179	1	204320179	PLEKHA6	Open sea	0.11	0.0186	0.0000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09613161	chr7:51384528	7	51384528	COBL	Island	0.22	0.0372	0.0000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03304380	chr8:13134144	8	13134144	DLC1	Island	0.28	0.0474	0.0000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05694245	chr10:28034816	10	28034816	MKX	Island	0.24	0.0406	0.0000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02951357	chr1:59280619	1	59280619	-	North shore	-0.1	0.0169	0.0000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25812095	chr2:144998514	2	144998514	GTDC1	Open sea	-0.07	0.0119	0.0000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06951627	chr6:26196580	6	26196580	-	North shore	-0.12	0.0203	0.0000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09587957	chr15:40399101	15	40399101	BMF	North shore	-0.06	0.0102	0.0000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01097768	chr5:378854	5	378854	AHRR	Open sea	-0.1	0.017	0.0000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24379915	chr8:29202958	8	29202958	DUSP4	North shelf	-0.09	0.0153	0.0000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24046474	chr9:130212550	9	130212550	RPL12;LRSAM1	North shore	-0.12	0.0203	0.0000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13585930	chr10:72027357	10	72027357	NPFFR1	Open sea	-0.11	0.0187	0.0000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13009111	chr11:71350975	11	71350975	-	Island	0.19	0.0322	0.0000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13167816	chr14:24601808	14	24601808	FITM1	South shore	0.08	0.0136	0.0000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05331214	chr2:167343774	2	167343774	SCN7A	Open sea	-0.13	0.0221	0.0000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23831876	chr2:65225988	2	65225988	SLC1A4	Open sea	-0.1	0.017	0.0000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02716826	chr9:33447032	9	33447032	SUGT1P1;AQP3	North shore	-0.08	0.0136	0.0000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21220374	chr9:100396777	9	100396777	TSTD2;NCBP1	South shore	-0.12	0.0204	0.0000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10401088	chr12:91505197	12	91505197	LUM	Open sea	-0.13	0.0221	0.0000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20146909	chr1:90289611	1	90289611	LRRC8D	South shelf	-0.08	0.0136	0.0000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05167251	chr2:176987465	2	176987465	HOXD9	Island	0.2	0.034	0.0000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16200531	chr2:135532566	2	135532566	-	Open sea	0.1	0.017	0.0000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02968508	chr3:9956698	3	9956698	IL17RE	North shore	-0.09	0.0153	0.0000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01548965	chr11:73088618	11	73088618	RELT	South shore	-0.08	0.0136	0.0000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15193228	chr22:30855332	22	30855332	SEC14L3	Open sea	-0.09	0.0153	0.0000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07202214	chr11:76381081	11	76381081	LRRC32	North shore	-0.1	0.017	0.000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09084200	chr11:134095863	11	134095863	VPS26B;NCAPD3	South shore	-0.1	0.017	0.000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23665802	chr13:92002338	13	92002338	MIR19A;MIR17HG;MIR92A1;MIR20A;MIR17;MIR19B1;MIR18A	South shore	-0.11	0.0187	0.000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00981877	chr20:50366841	20	50366841	ATP9A	Open sea	-0.16	0.0272	0.000000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27076487	chrX:140271364	X	140271364	LDOC1	Island	0.18	0.0306	0.0000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10165847	chr2:101436427	2	101436427	NPAS2	Island	0.28	0.0476	0.0000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16702313	chr14:74251926	14	74251926	C14orf43	North shore	-0.05	0.0085	0.0000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16622061	chr16:86888736	16	86888736	-	Open sea	-0.11	0.0187	0.0000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23348010	chr17:18908324	17	18908324	SLC5A10;FAM83G	South shore	-0.08	0.0136	0.0000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12975230	chr18:73167671	18	73167671	-	Island	0.34	0.0578	0.0000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11588903	chr19:17208493	19	17208493	MYO9B	North shelf	-0.1	0.017	0.0000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06121808	chr2:113404678	2	113404678	SLC20A1	South shore	-0.08	0.0136	0.0000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24632247	chr3:35680890	3	35680890	-	Island	0.17	0.0289	0.0000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01605984	chr9:136216154	9	136216154	SNORD24;SNORD36B;MED22;RPL7A;SNORD36A	South shore	-0.07	0.0119	0.0000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14014731	chr9:19378679	9	19378679	RPS6	North shore	-0.14	0.0238	0.0000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01017608	chr13:91627026	13	91627026	-	Open sea	-0.13	0.0221	0.0000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15089077	chr1:55246867	1	55246867	TTC22	Island	-0.13	0.0222	0.0000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10580293	chr7:29605897	7	29605897	PRR15	Island	-0.23	0.0392	0.0000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02370022	chr11:68866745	11	68866745	-	Open sea	0.16	0.0273	0.0000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09197783	chr11:57176720	11	57176720	SLC43A3	Open sea	-0.1	0.017	0.0000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01268763	chr14:53618419	14	53618419	DDHD1	North shore	-0.11	0.0187	0.0000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24704730	chr17:42061328	17	42061328	PYY	Island	0.38	0.0648	0.0000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12398645	chr5:174178693	5	174178693	-	Island	0.21	0.0358	0.0000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19071976	chr6:32026656	6	32026656	TNXB	Open sea	-0.12	0.0205	0.0000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27162705	chr10:114713024	10	114713024	TCF7L2	South shore	-0.11	0.0188	0.0000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17518710	chr11:113954170	11	113954170	ZBTB16	South shore	0.11	0.0188	0.0000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18641329	chr13:49070825	13	49070825	RCBTB2	Open sea	-0.08	0.0136	0.0000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02793162	chr15:68958534	15	68958534	CORO2B	Open sea	0.09	0.0153	0.0000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07657064	chr19:58609764	19	58609764	ZSCAN18	Island	0.19	0.0324	0.0000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16254756	chr1:154943676	1	154943676	SHC1	North shelf	-0.08	0.0136	0.0000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26468891	chr11:48077221	11	48077221	PTPRJ	Open sea	-0.09	0.0154	0.0000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03923640	chr16:87174624	16	87174624	-	Open sea	-0.11	0.0188	0.0000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02376827	chr17:1961510	17	1961510	HIC1	Island	0.09	0.0154	0.0000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02222791	chr14:88621424	14	88621424	-	Open sea	-0.18	0.0307	0.0000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23928726	chr1:2344998	1	2344998	PEX10	North shore	-0.09	0.0154	0.0000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12363682	chr5:178420690	5	178420690	GRM6	North shore	0.13	0.0222	0.0000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03037030	chr6:31543300	6	31543300	TNF	Open sea	-0.17	0.029	0.0000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12071328	chr11:20690930	11	20690930	NELL1	Island	0.18	0.0307	0.0000000048	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00174179	chr3:49450293	3	49450293	RHOA;TCTA	South shore	-0.05	0.0085	0.0000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05405914	chr16:8972233	16	8972233	-	Open sea	-0.11	0.0188	0.0000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11390378	chr4:147576227	4	147576227	-	Island	0.27	0.0462	0.000000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25485875	chr10:134600998	10	134600998	NKX6-2	Island	0.22	0.0376	0.0000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06505619	chr16:698072	16	698072	WDR90;FAM195A	North shore	-0.1	0.0171	0.0000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07198150	chr1:86623101	1	86623101	COL24A1	South shore	-0.08	0.0137	0.0000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20456243	chr2:220352476	2	220352476	SPEG	South shelf	-0.09	0.0154	0.0000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07408835	chr5:140306377	5	140306377	PCDHAC1;PCDHA7;PCDHA12;PCDHA6;PCDHA10;PCDHA4;PCDHA11;PCDHA8;PCDHA1;PCDHA2;PCDHA9;PCDHA13;PCDHA5;PCDHA3	Island	0.13	0.0223	0.0000000053	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12276019	chr8:11057947	8	11057947	XKR6	Island	-0.15	0.0257	0.0000000053	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23196831	chr8:121137537	8	121137537	COL14A1	Island	0.12	0.0206	0.0000000053	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19949550	chr14:94423704	14	94423704	ASB2	Open sea	-0.12	0.0206	0.0000000053	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20348746	chr2:188128809	2	188128809	-	Open sea	-0.15	0.0257	0.0000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19984355	chr5:1794232	5	1794232	-	Open sea	-0.11	0.0189	0.0000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15912800	chr7:27209197	7	27209197	MIR196B	Island	0.21	0.036	0.0000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13823169	chr9:139776893	9	139776893	-	North shelf	-0.06	0.0103	0.0000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04685387	chr10:34925640	10	34925640	PARD3	Open sea	-0.11	0.0189	0.0000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01111358	chr18:55102627	18	55102627	ONECUT2	Island	0.19	0.0326	0.0000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00540464	chr19:16655751	19	16655751	-	South shelf	-0.12	0.0206	0.0000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01587896	chr5:50678925	5	50678925	ISL1	Island	0.14	0.024	0.0000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15130459	chr5:40834228	5	40834228	SNORD72;RPL37	North shore	-0.1	0.0171	0.0000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16468187	chr16:4588687	16	4588687	C16orf5	Island	0.27	0.0463	0.0000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14920846	chr1:201618209	1	201618209	NAV1	Island	-0.14	0.024	0.0000000056	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09591072	chr3:184301468	3	184301468	-	Island	0.3	0.0515	0.0000000056	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00423486	chr1:8491132	1	8491132	RERE	Open sea	0.06	0.0103	0.0000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16355231	chr1:2344979	1	2344979	PEX10	North shore	-0.16	0.0275	0.0000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24621042	chr14:94857275	14	94857275	SERPINA1	Open sea	-0.07	0.012	0.0000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06811467	chr1:154299179	1	154299179	ATP8B2	North shore	-0.06	0.0103	0.0000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08324925	chr5:131409159	5	131409159	CSF2	Open sea	-0.1	0.0172	0.0000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13607323	chr5:124526339	5	124526339	-	Open sea	-0.09	0.0155	0.0000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09112156	chrX:140271259	X	140271259	LDOC1	Island	0.23	0.0395	0.0000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00055073	chr2:43398118	2	43398118	-	Island	0.13	0.0223	0.0000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02832697	chr4:154126481	4	154126481	TRIM2	Open sea	-0.07	0.012	0.0000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20408402	chr10:72362452	10	72362452	PRF1	South shore	0.05	0.0086	0.0000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03178798	chr18:10032699	18	10032699	-	Island	0.11	0.0189	0.0000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26719625	chr17:16322482	17	16322482	TRPV2	Open sea	-0.08	0.0137	0.0000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01240931	chr5:112074043	5	112074043	APC	Open sea	-0.08	0.0138	0.000000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16332631	chr11:64126102	11	64126102	RPS6KA4	North shore	-0.08	0.0138	0.000000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08122899	chr3:49499574	3	49499574	-	Open sea	-0.08	0.0138	0.0000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02637282	chr12:98768240	12	98768240	-	Open sea	0.13	0.0224	0.0000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06826457	chr12:12867669	12	12867669	-	North shelf	-0.1	0.0172	0.0000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21265439	chr14:103740033	14	103740033	-	Island	0.12	0.0206	0.0000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05824218	chr17:38499096	17	38499096	RARA	South shore	0.07	0.012	0.0000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11962640	chr1:19764686	1	19764686	CAPZB	Open sea	-0.16	0.0275	0.0000000062	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11877254	chr19:10222051	19	10222051	PPAN-P2RY11;P2RY11	South shore	-0.12	0.0206	0.0000000062	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17321385	chr2:132429793	2	132429793	-	North shore	-0.06	0.0103	0.0000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10171347	chr10:134600301	10	134600301	NKX6-2	Island	0.13	0.0224	0.0000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05733135	chr11:27740876	11	27740876	BDNF	Island	0.16	0.0275	0.0000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07635132	chr16:30441833	16	30441833	DCTPP1	South shore	-0.1	0.0172	0.0000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06901890	chr9:132803508	9	132803508	FNBP1	North shore	-0.11	0.0189	0.0000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03251079	chr12:66218285	12	66218285	HMGA2;RPSAP52	Island	0.1	0.0172	0.0000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06294803	chr3:184033282	3	184033282	EIF4G1	South shore	-0.11	0.019	0.0000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04425624	chr6:31543565	6	31543565	TNF	Open sea	-0.11	0.019	0.0000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16086620	chr14:93389557	14	93389557	CHGA	Island	0.21	0.0362	0.0000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26585644	chr16:2302081	16	2302081	DCI	South shore	-0.06	0.0103	0.0000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13325417	chr1:9161644	1	9161644	-	Open sea	-0.1	0.0172	0.0000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03438552	chr6:32805548	6	32805548	TAP2	North shore	-0.1	0.0172	0.0000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17372758	chr10:73976798	10	73976798	ASCC1;C10orf104	South shore	-0.12	0.0207	0.0000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21040569	chrX:137793665	X	137793665	FGF13	Island	0.17	0.0293	0.0000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01988129	chr8:67344936	8	67344936	ADHFE1	Island	0.19	0.0328	0.0000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19283840	chr8:67344642	8	67344642	ADHFE1	Island	0.14	0.0241	0.0000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20289688	chr11:17742502	11	17742502	MYOD1	Island	0.14	0.0241	0.0000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16144072	chrX:85403300	X	85403300	DACH2	Island	0.17	0.0293	0.0000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09537553	chr7:962492	7	962492	ADAP1	North shelf	-0.12	0.0207	0.0000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15013801	chr10:73976790	10	73976790	ASCC1;C10orf104	South shore	-0.17	0.0293	0.0000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09056317	chr19:36607008	19	36607008	TBCB;POLR2I	South shore	-0.07	0.0121	0.0000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14223444	chr9:100394496	9	100394496	TSTD2;NCBP1	North shore	-0.08	0.0138	0.0000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06930757	chr19:51216389	19	51216389	SHANK1	North shelf	0.06	0.0104	0.0000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03233656	chr2:65214625	2	65214625	SLC1A4	North shore	-0.12	0.0207	0.000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25611057	chr3:197121419	3	197121419	-	Open sea	-0.11	0.019	0.000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00599266	chr4:55967	4	55967	ZNF595;ZNF718	South shelf	0.05	0.0086	0.000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01290904	chr4:5708474	4	5708474	EVC2	North shore	-0.09	0.0155	0.000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07265588	chr4:6574480	4	6574480	-	North shelf	-0.1	0.0173	0.000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24636477	chr10:48439229	10	48439229	GDF10	Island	0.18	0.0311	0.000000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27332104	chr15:52386161	15	52386161	-	Open sea	0.09	0.0155	0.0000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21201657	chr19:5624574	19	5624574	SAFB	South shore	-0.06	0.0104	0.0000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10356429	chrX:64627572	X	64627572	-	Island	0.2	0.0346	0.0000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09636313	chr16:89070025	16	89070025	-	North shore	0.12	0.0207	0.0000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11410023	chr3:96533511	3	96533511	EPHA6	Island	0.16	0.0277	0.0000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12103569	chr12:132258560	12	132258560	SFRS8	Open sea	0.07	0.0121	0.0000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11993160	chr18:12404041	18	12404041	-	North shelf	-0.09	0.0156	0.0000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06577850	chr7:84002356	7	84002356	-	Open sea	-0.11	0.019	0.0000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25602684	chr5:37839918	5	37839918	GDNF	Island	0.3	0.0519	0.0000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13983319	chr9:116860500	9	116860500	KIF12	Island	0.18	0.0311	0.0000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01405107	chr17:46671635	17	46671635	LOC404266;HOXB5	North shore	-0.14	0.0242	0.0000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06488655	chr15:96903665	15	96903665	-	Island	0.19	0.0329	0.0000000077	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13087259	chr11:32193669	11	32193669	-	Open sea	-0.06	0.0104	0.0000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08857221	chr1:37941361	1	37941361	ZC3H12A	South shore	-0.07	0.0121	0.0000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08194879	chr6:123317569	6	123317569	CLVS2	Island	0.22	0.0381	0.0000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15246238	chr7:5635134	7	5635134	FSCN1	South shore	-0.12	0.0208	0.000000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02003183	chr14:103415882	14	103415882	CDC42BPB	Open sea	0.12	0.0208	0.000000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05371578	chr3:147128157	3	147128157	ZIC1	Island	0.14	0.0243	0.0000000081	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22940798	chr6:32805554	6	32805554	TAP2	North shore	-0.08	0.0139	0.0000000081	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26410450	chr11:17740967	11	17740967	MYOD1	Island	0.14	0.0243	0.0000000081	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08588626	chrX:17393327	X	17393327	NHS	Island	0.11	0.0191	0.0000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18295744	chr10:80872926	10	80872926	ZMIZ1	Open sea	-0.09	0.0156	0.0000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27228168	chr16:54320674	16	54320674	IRX3	Island	0.17	0.0295	0.0000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23441595	chr22:37273987	22	37273987	NCF4	Open sea	-0.09	0.0156	0.0000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18325389	chr7:116450458	7	116450458	-	Open sea	-0.09	0.0156	0.0000000083	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01218206	chr11:116933977	11	116933977	SIK3	Open sea	-0.08	0.0139	0.0000000083	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03372852	chr19:55219964	19	55219964	LILRP2	Open sea	0.11	0.0191	0.0000000083	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13976502	chr14:74227875	14	74227875	C14orf43	South shore	-0.09	0.0156	0.0000000084	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13876650	chr1:26146005	1	26146005	FAM54B	North shore	-0.05	0.0087	0.0000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23635560	chr2:27473369	2	27473369	-	Open sea	-0.08	0.0139	0.0000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08346159	chr4:164265012	4	164265012	NPY5R	Island	0.18	0.0313	0.0000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26850624	chr5:429559	5	429559	AHRR	Open sea	0.14	0.0243	0.0000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12275060	chr1:45279329	1	45279329	BTBD19	Island	-0.12	0.0209	0.0000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23300732	chr4:5053496	4	5053496	STK32B	Island	0.24	0.0417	0.0000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07432626	chr5:146889536	5	146889536	-	Island	0.19	0.033	0.0000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05142373	chr7:90894714	7	90894714	FZD1	Island	0.1	0.0174	0.0000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11012543	chr3:52231691	3	52231691	ALAS1	North shore	-0.09	0.0156	0.0000000088	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12284098	chr8:1993893	8	1993893	MYOM2	Open sea	0.13	0.0226	0.000000009	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09373037	chr10:46970625	10	46970625	SYT15	Island	0.21	0.0365	0.000000009	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11130317	chr14:103739856	14	103739856	-	Island	0.15	0.0261	0.000000009	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19712979	chr6:33173307	6	33173307	HSD17B8	South shore	-0.1	0.0174	0.0000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27337540	chr7:130698005	7	130698005	FLJ43663	Open sea	-0.1	0.0174	0.0000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08754967	chr10:736083	10	736083	DIP2C	South shore	0.11	0.0191	0.0000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04453552	chr16:57394387	16	57394387	CCL22	Open sea	-0.22	0.0383	0.0000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16028201	chr1:62784802	1	62784802	KANK4	Island	0.32	0.0557	0.0000000092	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22595230	chr20:3766560	20	3766560	CENPB	Island	-0.15	0.0261	0.0000000092	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22508831	chr22:40573204	22	40573204	TNRC6B	Open sea	-0.12	0.0209	0.0000000092	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21380860	chrX:106958499	X	106958499	TSC22D3	North shore	-0.11	0.0192	0.0000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17543112	chr5:131594335	5	131594335	PDLIM4	South shore	-0.08	0.0139	0.0000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02101876	chr13:40765110	13	40765110	-	Open sea	0.11	0.0192	0.0000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26236972	chr2:237921310	2	237921310	-	Open sea	-0.12	0.0209	0.0000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27457191	chr7:77429766	7	77429766	PHTF2	South shore	-0.09	0.0157	0.0000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00509772	chr20:32273129	20	32273129	E2F1	North shore	-0.06	0.0105	0.0000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24718722	chr10:129536818	10	129536818	FOXI2	Island	-0.18	0.0314	0.0000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01578875	chr4:146804010	4	146804010	ZNF827	Open sea	0.11	0.0192	0.0000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07469402	chr12:45444767	12	45444767	DBX2	Island	0.2	0.0349	0.0000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03859162	chr13:99404887	13	99404887	SLC15A1	Island	0.2	0.0349	0.0000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16646054	chr5:150157726	5	150157726	C5orf62	North shore	-0.09	0.0157	0.0000000098	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26038582	chr1:42384390	1	42384390	HIVEP3	South shore	0.2	0.0349	0.0000000099	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27271368	chrX:66764411	X	66764411	AR	North shore	0.15	0.0262	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00065905	chr1:116381304	1	116381304	NHLH2	Island	0.15	0.0262	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08991643	chr3:194014928	3	194014928	-	Island	-0.13	0.0227	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08998192	chr6:32805570	6	32805570	TAP2	North shore	-0.1	0.0174	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21381845	chr7:642127	7	642127	PRKAR1B	North shelf	-0.08	0.014	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14837598	chr8:21916635	8	21916635	EPB49	South shelf	-0.11	0.0192	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22761205	chr11:457256	11	457256	PTDSS2	North shore	0.07	0.0122	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00980784	chr17:47287577	17	47287577	ABI3;GNGT2	Open sea	-0.07	0.0122	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16626012	chr17:19437181	17	19437181	SLC47A1	Island	0.25	0.0436	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03359362	chr19:47289611	19	47289611	SLC1A5	North shore	-0.16	0.0279	0.00000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03542031	chr1:28906210	1	28906210	SNHG12;SNORD99	North shore	-0.07	0.0122	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03655142	chr1:153950843	1	153950843	JTB	South shore	-0.09	0.0157	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08869700	chr1:151318680	1	151318680	RFX5	North shore	-0.09	0.0157	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12059112	chr1:181287684	1	181287684	-	Island	0.14	0.0245	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27597853	chr2:150419026	2	150419026	-	Open sea	-0.1	0.0175	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08124030	chr3:149095283	3	149095283	TM4SF1	Open sea	-0.27	0.0472	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25205699	chr4:37246280	4	37246280	KIAA1239	Island	0.12	0.021	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12619504	chr5:179232533	5	179232533	SQSTM1;MGAT4B	Island	-0.09	0.0157	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10176110	chr6:168841653	6	168841653	SMOC2	Island	0.11	0.0192	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16580935	chr6:33246149	6	33246149	B3GALT4	South shore	-0.09	0.0157	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10478867	chr7:150948760	7	150948760	SMARCD3	Island	0.18	0.0315	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14080967	chr9:8857491	9	8857491	PTPRD	Island	0.19	0.0332	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14270346	chr9:38026076	9	38026076	SHB	Open sea	-0.12	0.021	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12250896	chr10:134001112	10	134001112	DPYSL4	Island	0.22	0.0385	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25103895	chr10:64565642	10	64565642	ADO	Island	-0.08	0.014	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17062268	chr12:5353230	12	5353230	-	Open sea	-0.07	0.0122	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13774342	chr13:50702795	13	50702795	-	North shore	-0.13	0.0227	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23619365	chr13:112712009	13	112712009	-	Island	0.21	0.0367	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04987734	chr14:103415873	14	103415873	CDC42BPB	Open sea	0.09	0.0157	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07146073	chr17:29852668	17	29852668	RAB11FIP4	Open sea	-0.1	0.0175	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19935040	chr17:42432165	17	42432165	FAM171A2	Island	-0.11	0.0192	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01017464	chr18:47018095	18	47018095	SNORD58A;SNORD58B;RPL17	North shore	-0.13	0.0227	0.000000011	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08922729	chr1:21913557	1	21913557	-	Open sea	-0.09	0.0158	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08472795	chr2:129067253	2	129067253	HS6ST1	Open sea	-0.1	0.0175	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00382138	chr4:110723299	4	110723299	CFI	Open sea	-0.11	0.0193	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27655158	chr4:1396593	4	1396593	-	Island	0.28	0.0491	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18036734	chr5:177036766	5	177036766	B4GALT7	South shore	-0.08	0.014	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26908328	chr5:79552537	5	79552537	SERINC5	South shore	-0.11	0.0193	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00668559	chr6:44230977	6	44230977	NFKBIE	North shore	-0.11	0.0193	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02654940	chr6:34206400	6	34206400	HMGA1	South shore	-0.06	0.0105	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15132169	chr6:149805995	6	149805995	ZC3H12D	Open sea	-0.11	0.0193	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18451588	chr7:29606289	7	29606289	PRR15	Island	-0.25	0.0439	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01072821	chr8:10382165	8	10382165	T-SP1	Open sea	-0.09	0.0158	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04850999	chr10:77872084	10	77872084	C10orf11	Island	-0.12	0.0211	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02768162	chr12:108992148	12	108992148	TMEM119	Open sea	-0.07	0.0123	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05222995	chr12:115124973	12	115124973	-	Island	0.14	0.0246	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05673756	chr13:102068650	13	102068650	NALCN	Island	0.22	0.0386	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07115542	chr14:36988443	14	36988443	NKX2-1	Island	0.2	0.0351	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15817482	chr14:94423801	14	94423801	ASB2	Open sea	-0.07	0.0123	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11445634	chr15:61821004	15	61821004	-	Open sea	-0.12	0.0211	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16062877	chr17:25798415	17	25798415	KSR1	Open sea	-0.06	0.0105	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27200006	chr22:25003854	22	25003854	GGT1	Open sea	-0.13	0.0228	0.000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04913057	chr1:204120825	1	204120825	ETNK2	Island	0.29	0.051	0.000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01829024	chr4:83482926	4	83482926	TMEM150C	Island	0.15	0.0264	0.000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02781618	chr4:42153695	4	42153695	BEND4	Island	0.14	0.0246	0.000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02268229	chr4:141490037	4	141490037	UCP1	Island	0.19	0.0334	0.000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14442492	chr5:95296150	5	95296150	ELL2	North shore	-0.09	0.0158	0.000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09716613	chr13:33000534	13	33000534	N4BP2L1	North shore	0.1	0.0176	0.000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23766254	chr17:42431859	17	42431859	FAM171A2	Island	-0.15	0.0264	0.000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10416593	chr22:50966123	22	50966123	TYMP;SCO2	Island	-0.1	0.0176	0.000000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18137450	chr1:224620806	1	224620806	WDR26	North shore	-0.09	0.0159	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18375860	chr1:237205409	1	237205409	RYR2	Island	0.18	0.0317	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05279864	chr7:87109319	7	87109319	-	Open sea	-0.11	0.0194	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21333674	chr8:96705765	8	96705765	-	Open sea	-0.12	0.0212	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02388253	chr9:123640363	9	123640363	PHF19	South shore	-0.11	0.0194	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16459519	chr10:46970584	10	46970584	SYT15	Island	0.24	0.0423	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23266743	chr12:130388198	12	130388198	TMEM132D	Island	0.12	0.0212	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18125510	chr14:100841768	14	100841768	WARS;WDR25	North shore	-0.13	0.0229	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07285481	chr16:81667167	16	81667167	CMIP	Open sea	-0.07	0.0123	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17295878	chr17:77924665	17	77924665	TBC1D16	South shore	-0.17	0.03	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.07	0.0123	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13092901	chr22:50965373	22	50965373	TYMP;SCO2	Island	-0.12	0.0212	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01431482	chr1:2989085	1	2989085	PRDM16	North shore	-0.11	0.0194	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04788999	chr1:949850	1	949850	ISG15	Island	-0.1	0.0177	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00085013	chr3:14871570	3	14871570	FGD5	Open sea	0.07	0.0124	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16582517	chr3:5025885	3	5025885	BHLHE40	South shore	-0.12	0.0212	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26636193	chr5:146889265	5	146889265	-	Island	0.17	0.03	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01331992	chr9:19379118	9	19379118	RPS6	North shore	-0.13	0.023	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27495903	chr10:21463009	10	21463009	NEBL	Island	0.18	0.0318	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08962087	chr13:29107120	13	29107120	-	Island	0.13	0.023	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08604596	chr16:28565976	16	28565976	CCDC101	South shore	-0.08	0.0141	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04117801	chr17:46651867	17	46651867	HOXB3	North shelf	-0.16	0.0283	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20098015	chr22:50971140	22	50971140	ODF3B	South shore	-0.09	0.0159	0.000000015	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05759718	chr1:50489596	1	50489596	AGBL4	Island	0.26	0.046	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24541193	chr1:169433715	1	169433715	SLC19A2	Open sea	0.1	0.0177	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25591888	chr2:235890080	2	235890080	SH3BP4	Open sea	-0.06	0.0106	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10663765	chr3:194014592	3	194014592	-	Island	-0.15	0.0265	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05251676	chr5:38258884	5	38258884	EGFLAM	Island	0.27	0.0478	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03149958	chr6:36326677	6	36326677	-	Open sea	-0.13	0.023	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06783737	chr6:26752689	6	26752689	-	Open sea	0.15	0.0265	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15594967	chr6:55444079	6	55444079	HMGCLL1	Island	0.09	0.0159	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14537362	chr9:129376508	9	129376508	LMX1B	Island	0.26	0.046	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00326958	chr10:43892075	10	43892075	HNRNPF	Island	-0.14	0.0248	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07443710	chr10:71206848	10	71206848	-	Open sea	-0.09	0.0159	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27557378	chr16:2286786	16	2286786	DNASE1L2	Island	0.15	0.0265	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08446900	chr17:38501519	17	38501519	RARA	Island	0.16	0.0283	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25385366	chr21:43809360	21	43809360	TMPRSS3	Open sea	0.1	0.0177	0.000000016	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00788170	chr1:227921688	1	227921688	SNAP47;LOC100130093;JMJD4	North shore	-0.05	0.0089	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26811385	chr4:150832003	4	150832003	-	Open sea	-0.12	0.0213	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08553327	chr6:31543647	6	31543647	TNF	Open sea	-0.15	0.0266	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16052901	chr6:33240864	6	33240864	VPS52;RPS18	South shore	-0.11	0.0195	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27303735	chr6:30709605	6	30709605	FLOT1	North shore	-0.1	0.0177	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00921574	chr7:1513873	7	1513873	INTS1	Island	-0.1	0.0177	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15261712	chr7:92238248	7	92238248	CDK6	Open sea	0.11	0.0195	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18825427	chr7:155079356	7	155079356	-	Open sea	-0.08	0.0142	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26521404	chr7:27204981	7	27204981	HOXA9	Island	0.26	0.0461	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09820716	chr8:8580928	8	8580928	-	Island	0.13	0.023	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06617456	chr8:68864769	8	68864769	PREX2	Island	0.19	0.0337	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19884262	chr10:129535968	10	129535968	FOXI2	Island	0.17	0.0301	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26579578	chr11:69707303	11	69707303	-	South shore	-0.25	0.0443	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03004371	chr15:101423806	15	101423806	ALDH1A3	South shelf	0.14	0.0248	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14093936	chr15:74726614	15	74726614	SEMA7A	South shore	-0.07	0.0124	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18177814	chr16:50730881	16	50730881	NOD2	Open sea	-0.06	0.0106	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27093918	chr16:69564625	16	69564625	-	Open sea	-0.11	0.0195	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00524443	chr17:46650310	17	46650310	HOXB3	North shelf	-0.08	0.0142	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22533683	chr17:29887049	17	29887049	MIR193A	Island	-0.1	0.0177	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23057648	chr21:40984763	21	40984763	C21orf88	Open sea	0.12	0.0213	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18473686	chr22:33427086	22	33427086	SYN3	Open sea	-0.07	0.0124	0.000000017	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12483476	chr5:178421711	5	178421711	GRM6	Island	0.26	0.0462	0.000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11961845	chr7:129008179	7	129008179	AHCYL2	Open sea	-0.08	0.0142	0.000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12746356	chr10:124220874	10	124220874	HTRA1	Island	0.2	0.0355	0.000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18765366	chr17:31528	17	31528	DOC2B	Island	0.22	0.0391	0.000000018	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06779802	chrX:107979401	X	107979401	IRS4	Island	0.2	0.0356	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01422881	chr1:44873692	1	44873692	RNF220	Island	0.1	0.0178	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04843111	chr1:156617074	1	156617074	BCAN	South shore	-0.07	0.0125	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07913294	chr1:50489574	1	50489574	AGBL4	Island	0.17	0.0302	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06264984	chr2:38300885	2	38300885	CYP1B1	North shore	0.09	0.016	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08867399	chr2:129077561	2	129077561	HS6ST1	Island	-0.13	0.0231	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13547053	chr2:179184864	2	179184864	OSBPL6	Open sea	0.08	0.0142	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26076054	chr5:421317	5	421317	AHRR	Island	0.34	0.0605	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18676273	chr7:41732833	7	41732833	INHBA;LOC285954	Open sea	-0.1	0.0178	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17078116	chr8:24772344	8	24772344	NEFM	Island	0.17	0.0302	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16357921	chr9:90589634	9	90589634	CDK20	Island	0.15	0.0267	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15266205	chr12:15749418	12	15749418	PTPRO	Open sea	-0.11	0.0196	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26282236	chr12:1025755	12	1025755	RAD52	Open sea	0.11	0.0196	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14936269	chr16:1968232	16	1968232	HS3ST6	Island	0.18	0.032	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27118035	chr16:31891978	16	31891978	ZNF267	Open sea	0.12	0.0213	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01760189	chr17:35656896	17	35656896	ACACA	Open sea	-0.13	0.0231	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05460226	chr17:8804279	17	8804279	PIK3R5	Open sea	-0.13	0.0231	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03969725	chr20:44442019	20	44442019	UBE2C	South shore	-0.08	0.0142	0.000000019	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08042975	chr2:213402433	2	213402433	ERBB4	Island	0.15	0.0267	0.00000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25711003	chr3:111522050	3	111522050	PHLDB2;PLCXD2	Open sea	0.12	0.0214	0.00000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04481603	chr10:104182930	10	104182930	-	South shore	-0.11	0.0196	0.00000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20186445	chr10:48439220	10	48439220	GDF10	Island	0.11	0.0196	0.00000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23198334	chr10:76179907	10	76179907	ADK	Open sea	0.1	0.0178	0.00000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24105081	chr12:1947479	12	1947479	CACNA2D4	Open sea	-0.18	0.0321	0.00000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21586223	chr13:49227121	13	49227121	-	Open sea	-0.07	0.0125	0.00000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15222899	chr18:55095249	18	55095249	-	Island	0.2	0.0356	0.00000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20716932	chr20:31331814	20	31331814	COMMD7	South shore	-0.08	0.0143	0.00000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06803614	chr1:40133581	1	40133581	NT5C1A	North shelf	-0.1	0.0178	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20664247	chr1:2345475	1	2345475	PEX10	North shore	-0.09	0.0161	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01880096	chr2:46558	2	46558	FAM110C	Island	0.15	0.0268	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04864807	chr2:121412139	2	121412139	-	Island	0.18	0.0321	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16541026	chr3:49026934	3	49026934	P4HTM	North shore	-0.1	0.0178	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14127947	chr4:8271196	4	8271196	HTRA3	North shore	-0.11	0.0196	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25722465	chr4:55991701	4	55991701	KDR	Island	0.16	0.0286	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14264316	chr9:134280803	9	134280803	-	Open sea	-0.09	0.0161	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06525651	chr10:128994297	10	128994297	FAM196A;DOCK1	Island	0.26	0.0464	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04313565	chr16:17561865	16	17561865	XYLT1	Open sea	-0.09	0.0161	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09623400	chr20:24450353	20	24450353	TMEM90B	Island	0.19	0.0339	0.000000021	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03963219	chr2:84709147	2	84709147	-	Open sea	0.12	0.0214	0.000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19951663	chr5:134871634	5	134871634	NEUROG1	Island	0.11	0.0197	0.000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17501210	chr6:166970252	6	166970252	RPS6KA2	Open sea	-0.11	0.0197	0.000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21429551	chr7:30635762	7	30635762	GARS	South shore	-0.14	0.025	0.000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13723825	chr9:8857502	9	8857502	PTPRD	Island	0.16	0.0286	0.000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27649239	chr15:68120393	15	68120393	LBXCOR1	Island	0.13	0.0232	0.000000022	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03144619	chr1:230415668	1	230415668	GALNT2	Island	-0.2	0.0358	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25618424	chr1:2989307	1	2989307	PRDM16	North shore	-0.08	0.0143	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00498211	chr2:65217568	2	65217568	SLC1A4	South shore	-0.19	0.034	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02422426	chr4:183370059	4	183370059	ODZ3	Island	0.25	0.0447	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01617071	chr7:964629	7	964629	ADAP1	North shore	-0.1	0.0179	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03092191	chr7:1272710	7	1272710	UNCX	Island	0.17	0.0304	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00524374	chr10:3894968	10	3894968	-	Open sea	-0.11	0.0197	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15806304	chr10:119000083	10	119000083	SLC18A2	North shore	0.07	0.0125	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23256579	chr12:11002403	12	11002403	PRR4	Open sea	0.13	0.0233	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16582779	chr14:29237202	14	29237202	FOXG1	Island	0.06	0.0107	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16729415	chr15:35047203	15	35047203	GJD2	Island	0.28	0.0501	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08861091	chr19:51891339	19	51891339	LIM2	Open sea	-0.07	0.0125	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06000883	chr21:39288720	21	39288720	KCNJ6	Island	0.14	0.0251	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08507178	chr22:50357265	22	50357265	PIM3	South shore	-0.05	0.0089	0.000000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14340500	chrX:142723216	X	142723216	SLITRK4	South shore	0.14	0.0251	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15089806	chr1:43418199	1	43418199	SLC2A1	Open sea	-0.06	0.0108	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07166409	chr2:97534057	2	97534057	SEMA4C	North shore	-0.13	0.0233	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16744741	chr4:82126025	4	82126025	PRKG2	Open sea	0.09	0.0161	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27448110	chr7:157484647	7	157484647	PTPRN2	Island	0.09	0.0161	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04388657	chr9:127623377	9	127623377	RPL35	North shore	-0.12	0.0215	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10387551	chr11:30038615	11	30038615	KCNA4	Island	0.19	0.034	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13633560	chr11:76380921	11	76380921	LRRC32	North shore	-0.12	0.0215	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27560292	chr11:6632884	11	6632884	TAF10	Island	-0.07	0.0125	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16497398	chr16:87470083	16	87470083	ZCCHC14	Open sea	-0.09	0.0161	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26695387	chr17:21189768	17	21189768	MAP2K3	South shore	-0.13	0.0233	0.000000024	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13246856	chr1:44399776	1	44399776	ARTN	North shore	-0.09	0.0161	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03395188	chr2:219266059	2	219266059	CTDSP1;MIR26B	South shore	-0.07	0.0126	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22417733	chr6:153303409	6	153303409	FBXO5	Island	-0.15	0.0269	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01874697	chr10:106401517	10	106401517	SORCS3	Island	0.12	0.0215	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07918545	chr10:129535669	10	129535669	FOXI2	Island	0.17	0.0305	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16494192	chr10:50818652	10	50818652	SLC18A3;CHAT	Island	0.16	0.0287	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23731595	chr10:30346789	10	30346789	KIAA1462	North shore	-0.1	0.0179	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24591300	chr10:100993025	10	100993025	HPSE2	North shore	-0.06	0.0108	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23162201	chr11:8280741	11	8280741	LMO1	North shelf	0.12	0.0215	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22851561	chr14:74214183	14	74214183	C14orf43	Open sea	-0.11	0.0197	0.000000025	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12202185	chr5:369088	5	369088	AHRR	North shore	-0.21	0.0377	0.000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05593715	chr8:95056896	8	95056896	-	Open sea	-0.1	0.018	0.000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19154600	chr10:75415868	10	75415868	SYNPO2L	Open sea	0.07	0.0126	0.000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07677157	chr12:66050928	12	66050928	-	Open sea	-0.18	0.0323	0.000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18033416	chr17:30592033	17	30592033	RHBDL3	North shore	-0.08	0.0144	0.000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03502002	chr18:74962133	18	74962133	GALR1	Island	0.23	0.0413	0.000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22304612	chr20:2781241	20	2781241	CPXM1	Island	0.16	0.0287	0.000000026	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08790440	chr2:124782831	2	124782831	CNTNAP5	Island	0.1	0.018	0.000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25013095	chr2:231809672	2	231809672	-	Open sea	-0.14	0.0252	0.000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20953187	chr3:45837898	3	45837898	SLC6A20	Island	0.19	0.0342	0.000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09500443	chr5:180018465	5	180018465	SCGB3A1	Island	0.15	0.027	0.000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10717214	chr6:31543557	6	31543557	TNF	Open sea	-0.11	0.0198	0.000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12892004	chr6:117198278	6	117198278	RFX6	Island	0.14	0.0252	0.000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16190732	chr19:34113010	19	34113010	CHST8	Island	0.22	0.0396	0.000000027	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12622182	chr1:38513641	1	38513641	POU3F1	Island	-0.06	0.0108	0.000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11674448	chr1:41711766	1	41711766	-	South shelf	0.12	0.0216	0.000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16371538	chr1:37940813	1	37940813	ZC3H12A	South shore	-0.14	0.0252	0.000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09295081	chr2:11810183	2	11810183	NTSR2	Island	0.15	0.027	0.000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00867018	chr3:128268051	3	128268051	-	Open sea	-0.12	0.0216	0.000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14094960	chr7:55086890	7	55086890	EGFR	Island	0.16	0.0288	0.000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10061906	chr8:146013430	8	146013430	ZNF34	South shore	-0.08	0.0144	0.000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26878655	chr17:38481877	17	38481877	RARA	Open sea	-0.09	0.0162	0.000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26918577	chr17:75888026	17	75888026	-	South shelf	-0.07	0.0126	0.000000028	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08798116	chrX:132548882	X	132548882	GPC4	Island	0.26	0.0469	0.000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25987936	chrX:66765446	X	66765446	AR	North shore	0.16	0.0288	0.000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27528222	chr1:2138953	1	2138953	C1orf86	South shore	-0.17	0.0306	0.000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14435720	chr9:139565087	9	139565087	EGFL7;MIR126	Island	-0.24	0.0433	0.000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16555466	chr14:92042333	14	92042333	C14orf184	South shore	-0.1	0.018	0.000000029	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13663706	chrX:144899995	X	144899995	SLITRK2	Island	0.28	0.0505	0.00000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19731612	chr5:176559334	5	176559334	NSD1	Island	-0.16	0.0289	0.00000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12289251	chr10:18689471	10	18689471	CACNB2	Open sea	-0.23	0.0415	0.00000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27430293	chr16:89069935	16	89069935	-	North shore	0.11	0.0199	0.00000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22006825	chr19:41771771	19	41771771	HNRNPUL1	South shore	-0.05	0.009	0.00000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15645660	chr1:55247356	1	55247356	TTC22	Island	-0.23	0.0415	0.000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24047802	chr1:223936343	1	223936343	CAPN2	Island	-0.1	0.0181	0.000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12214451	chr4:114900175	4	114900175	ARSJ	North shore	-0.08	0.0145	0.000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04053392	chr6:168720505	6	168720505	DACT2	South shore	0.14	0.0253	0.000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07413467	chr7:92238086	7	92238086	CDK6	Open sea	0.1	0.0181	0.000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11961495	chr10:80873797	10	80873797	ZMIZ1	Open sea	-0.09	0.0163	0.000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24064224	chr10:1156594	10	1156594	WDR37	Open sea	-0.08	0.0145	0.000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00944304	chr15:40738072	15	40738072	BAHD1	South shelf	-0.07	0.0126	0.000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06442240	chr16:19129228	16	19129228	ITPRIPL2	South shore	-0.12	0.0217	0.000000031	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20975182	chr1:32207700	1	32207700	BAI2	North shore	-0.08	0.0145	0.000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26904049	chr1:167091094	1	167091094	DUSP27	South shore	-0.09	0.0163	0.000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22061831	chr2:131721692	2	131721692	ARHGEF4	Island	0.26	0.047	0.000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10843276	chr4:726697	4	726697	PCGF3	South shore	0.1	0.0181	0.000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14036479	chr7:155250220	7	155250220	EN2	Island	0.1	0.0181	0.000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06808751	chr8:54163693	8	54163693	OPRK1	Island	0.17	0.0307	0.000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06819923	chr16:21214508	16	21214508	ZP2	Open sea	-0.09	0.0163	0.000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06442294	chr19:18404194	19	18404194	-	South shore	-0.11	0.0199	0.000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19426731	chr19:49992527	19	49992527	RPL13AP5;SNORD33;SNORD32A;RPL13A	South shore	-0.12	0.0217	0.000000032	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01937809	chr1:37941854	1	37941854	ZC3H12A	South shore	-0.09	0.0163	0.000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21604136	chr1:9910137	1	9910137	CTNNBIP1	Open sea	0.06	0.0109	0.000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04207084	chr7:157477846	7	157477846	PTPRN2	Island	0.15	0.0272	0.000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14024579	chr9:139332845	9	139332845	INPP5E	Island	-0.08	0.0145	0.000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17910121	chr10:28034669	10	28034669	MKX	Island	0.1	0.0181	0.000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03620853	chr19:41698931	19	41698931	CYP2S1	Island	0.16	0.029	0.000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01068944	chr20:9049273	20	9049273	-	Island	0.24	0.0434	0.000000033	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09720420	chrX:142722174	X	142722174	SLITRK4	Island	0.12	0.0217	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16108684	chrX:125300035	X	125300035	DCAF12L2	Island	0.16	0.029	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00988350	chr1:24126048	1	24126048	GALE	North shore	-0.06	0.0109	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11563680	chr6:100917397	6	100917397	-	Island	0.12	0.0217	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19190163	chr6:32810785	6	32810785	PSMB8	North shore	-0.1	0.0181	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25843346	chr6:31762555	6	31762555	VARS	North shore	-0.06	0.0109	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14475702	chr9:110251003	9	110251003	KLF4	Island	0.21	0.038	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03070297	chr10:128994603	10	128994603	DOCK1;FAM196A	Island	0.2	0.0362	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21631918	chr15:74501549	15	74501549	STRA6	Open sea	-0.07	0.0127	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02732508	chr16:89628853	16	89628853	RPL13	South shore	-0.11	0.0199	0.000000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04486013	chr1:46035287	1	46035287	AKR1A1	Open sea	-0.07	0.0127	0.000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06801385	chr5:1152362	5	1152362	-	North shelf	-0.09	0.0163	0.000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11152384	chr11:68934300	11	68934300	-	Open sea	-0.13	0.0236	0.000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26809635	chr12:54355087	12	54355087	-	Island	0.18	0.0326	0.000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03217253	chr19:53758055	19	53758055	ZNF677	Island	0.24	0.0435	0.000000035	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19098763	chr1:50513661	1	50513661	ELAVL4	Island	0.17	0.0309	0.000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24844545	chr1:11908347	1	11908347	NPPA	Open sea	0.12	0.0218	0.000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01751245	chr2:65593761	2	65593761	SPRED2	Open sea	-0.13	0.0236	0.000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17161250	chr2:106682209	2	106682209	C2orf40	Island	0.22	0.0399	0.000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17178175	chr2:178109973	2	178109973	NFE2L2	Open sea	-0.09	0.0163	0.000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02402368	chr8:6420726	8	6420726	ANGPT2;MCPH1	North shelf	-0.12	0.0218	0.000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02523640	chr10:129534613	10	129534613	FOXI2	Island	0.22	0.0399	0.000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01120509	chr16:698230	16	698230	WDR90;FAM195A	North shore	-0.06	0.0109	0.000000036	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13570831	chr1:239550303	1	239550303	-	Island	0.29	0.0527	0.000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06298346	chr5:10565679	5	10565679	ANKRD33B	Island	-0.1	0.0182	0.000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20993909	chr8:916135	8	916135	-	South shore	-0.08	0.0145	0.000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09419102	chr11:65550444	11	65550444	-	South shore	-0.07	0.0127	0.000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05660670	chr12:20521635	12	20521635	PDE3A	Island	0.17	0.0309	0.000000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16554164	chr1:32410678	1	32410678	-	South shore	-0.08	0.0145	0.000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00122854	chr2:218898491	2	218898491	-	Island	-0.06	0.0109	0.000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05963604	chr3:57263543	3	57263543	APPL1	South shore	-0.11	0.02	0.000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20674424	chr3:186503527	3	186503527	MIR1248;EIF4A2;SNORA81	South shore	-0.11	0.02	0.000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03544320	chr4:5894691	4	5894691	CRMP1	Island	0.24	0.0436	0.000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22274395	chr4:141490067	4	141490067	UCP1	Island	0.24	0.0436	0.000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22858500	chr10:18629006	10	18629006	CACNB2	Open sea	-0.09	0.0164	0.000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01109535	chr16:24856104	16	24856104	SLC5A11	Open sea	-0.06	0.0109	0.000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05796223	chr16:21532721	16	21532721	SLC7A5P2	South shore	-0.07	0.0127	0.000000038	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05135521	chr2:161188335	2	161188335	RBMS1	Open sea	-0.11	0.02	0.000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06187947	chr2:189157042	2	189157042	GULP1	Island	0.09	0.0164	0.000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08323075	chr4:5053504	4	5053504	STK32B	Island	0.2	0.0364	0.000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25351606	chr6:100917427	6	100917427	-	Island	0.12	0.0218	0.000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00232092	chr7:5518887	7	5518887	FBXL18	North shelf	-0.08	0.0146	0.000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04220047	chr8:65714735	8	65714735	-	South shelf	-0.11	0.02	0.000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14681767	chr8:1772393	8	1772393	ARHGEF10	Island	0.16	0.0291	0.000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01212887	chr13:95364514	13	95364514	SOX21	Island	0.12	0.0218	0.000000039	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11789321	chr5:56773063	5	56773063	-	Open sea	-0.09	0.0164	0.00000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09762515	chr7:101556588	7	101556588	CUX1	North shelf	0.1	0.0182	0.00000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00780520	chr8:128808554	8	128808554	PVT1	South shore	-0.09	0.0164	0.00000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13021857	chr8:131740091	8	131740091	-	Open sea	-0.15	0.0273	0.00000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12868067	chr12:128752246	12	128752246	TMEM132C	Island	0.16	0.0291	0.00000004	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07533148	chr1:248020812	1	248020812	TRIM58	Island	0.25	0.0456	0.000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25799109	chr3:57102900	3	57102900	ARHGEF3;SPATA12	Open sea	-0.12	0.0219	0.000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21055554	chr12:113652889	12	113652889	IQCD	Open sea	-0.1	0.0182	0.000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13105904	chr14:24900044	14	24900044	CBLN3;KHNYN	South shore	-0.23	0.0419	0.000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27050153	chr14:102030110	14	102030110	-	Island	0.08	0.0146	0.000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18474153	chr19:3984323	19	3984323	EEF2	North shore	-0.08	0.0146	0.000000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01718116	chr2:115919829	2	115919829	DPP10	Island	0.15	0.0274	0.000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14502484	chr5:1446208	5	1446208	SLC6A3	Island	0.18	0.0328	0.000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24804707	chr8:134094173	8	134094173	TG;SLA	Open sea	0.11	0.0201	0.000000042	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19206040	chr1:37500441	1	37500441	GRIK3	Island	0.18	0.0329	0.000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13721397	chr9:131831038	9	131831038	FAM73B	Open sea	0.07	0.0128	0.000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07052041	chr10:135092104	10	135092104	-	South shore	-0.14	0.0256	0.000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24642825	chr15:89248793	15	89248793	-	Open sea	0.14	0.0256	0.000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13613146	chr16:29625989	16	29625989	SLC7A5P1	South shore	-0.07	0.0128	0.000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24148361	chr17:12388639	17	12388639	-	Open sea	-0.07	0.0128	0.000000043	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26859016	chr1:206643375	1	206643375	IKBKE	Open sea	-0.09	0.0164	0.000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26369418	chr5:131409352	5	131409352	CSF2	Open sea	-0.09	0.0164	0.000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11073558	chr8:97171901	8	97171901	GDF6	Island	0.14	0.0256	0.000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03131366	chr12:2041707	12	2041707	-	Open sea	0.09	0.0164	0.000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12036924	chr19:5838731	19	5838731	FUT6	Open sea	0.08	0.0146	0.000000044	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09767602	chr4:183370138	4	183370138	ODZ3	Island	0.22	0.0402	0.000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25260137	chr8:65282185	8	65282185	-	Island	0.17	0.0311	0.000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11748187	chr10:114713108	10	114713108	TCF7L2	South shore	-0.13	0.0238	0.000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21860825	chr12:19358289	12	19358289	PLEKHA5	Open sea	0.1	0.0183	0.000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27423760	chr16:51186463	16	51186463	SALL1	Island	0.18	0.0329	0.000000045	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09907720	chr2:71127565	2	71127565	VAX2	Island	0.13	0.0238	0.000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02165355	chr5:178368071	5	178368071	ZNF454	Island	0.11	0.0201	0.000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00749672	chr7:26437192	7	26437192	-	North shore	-0.09	0.0165	0.000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20536983	chr8:13134166	8	13134166	DLC1	Island	0.2	0.0366	0.000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00916884	chr16:56666334	16	56666334	MT1M	Island	0.29	0.0531	0.000000046	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26126879	chr8:103916295	8	103916295	-	Open sea	0.11	0.0201	0.000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12646649	chr10:102987257	10	102987257	LBX1	Island	0.17	0.0311	0.000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25073093	chr11:64458129	11	64458129	NRXN2	Open sea	-0.1	0.0183	0.000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02158978	chr12:133134938	12	133134938	FBRSL1	North shore	0.08	0.0146	0.000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12745325	chr12:56623942	12	56623942	SLC39A5	Open sea	-0.09	0.0165	0.000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00830621	chr16:18799106	16	18799106	RPS15A	North shelf	-0.09	0.0165	0.000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03076094	chr16:4357346	16	4357346	-	North shore	-0.06	0.011	0.000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08233235	chr19:55898727	19	55898727	RPL28	South shore	-0.1	0.0183	0.000000047	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18315963	chr4:30723455	4	30723455	PCDH7	Island	0.13	0.0238	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26541867	chr4:37246688	4	37246688	KIAA1239	Island	0.23	0.0422	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19418648	chr5:176789979	5	176789979	RGS14	Island	-0.07	0.0128	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27460040	chr8:38648995	8	38648995	TACC1	South shelf	-0.1	0.0183	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13962186	chr9:79633650	9	79633650	FOXB2	Island	0.12	0.022	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23574897	chr10:102988836	10	102988836	LBX1;FLJ41350	Island	0.18	0.033	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11360522	chr13:113379828	13	113379828	ATP11A	North shelf	0.08	0.0147	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05248321	chr14:20898128	14	20898128	KLHL33	Open sea	0.09	0.0165	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05638787	chr15:41062273	15	41062273	DNAJC17;C15orf62	Open sea	0.05	0.0092	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24848615	chr19:3368396	19	3368396	NFIC	North shore	-0.09	0.0165	0.000000049	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23913963	chr1:17766917	1	17766917	RCC2	South shore	-0.11	0.0202	0.00000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14752525	chr2:223927446	2	223927446	-	Open sea	-0.09	0.0165	0.00000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03625260	chr6:17102391	6	17102391	-	Island	0.15	0.0275	0.00000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03348792	chr12:53075482	12	53075482	KRT1	Open sea	0.09	0.0165	0.00000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06501716	chr22:19436948	22	19436948	C22orf39	South shore	-0.09	0.0165	0.00000005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19715410	chr1:29139021	1	29139021	OPRD1	Island	0.27	0.0496	0.000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22383924	chr1:3590479	1	3590479	TP73	Open sea	-0.06	0.011	0.000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23762517	chr1:42384310	1	42384310	HIVEP3	South shore	0.16	0.0294	0.000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17230874	chr3:125932073	3	125932073	-	Island	0.11	0.0202	0.000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12250496	chr4:62066787	4	62066787	-	Island	0.16	0.0294	0.000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02956248	chr6:32120901	6	32120901	PPT2;PRRT1	North shore	-0.22	0.0404	0.000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08742502	chr6:106546754	6	106546754	PRDM1	Open sea	-0.13	0.0239	0.000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03641640	chr13:114776416	13	114776416	RASA3	South shore	-0.13	0.0239	0.000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15144068	chr14:106321751	14	106321751	-	Island	-0.1	0.0184	0.000000051	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10527010	chr3:10857795	3	10857795	SLC6A11	Island	0.16	0.0294	0.000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02032558	chr4:155662438	4	155662438	-	North shore	-0.1	0.0184	0.000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13973820	chr6:55444072	6	55444072	HMGCLL1	Island	0.11	0.0202	0.000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20640261	chr6:31707019	6	31707019	MSH5	North shore	-0.09	0.0165	0.000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22209010	chr6:166851891	6	166851891	RPS6KA2	Open sea	0.09	0.0165	0.000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04496906	chr8:145101182	8	145101182	SPATC1	North shore	-0.06	0.011	0.000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10094616	chr8:53478023	8	53478023	FAM150A	Island	0.2	0.0367	0.000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24847230	chr17:46986807	17	46986807	UBE2Z	South shore	-0.04	0.0073	0.000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13370427	chr22:40743980	22	40743980	ADSL	South shore	-0.07	0.0129	0.000000052	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17571335	chr11:128559701	11	128559701	-	North shore	-0.13	0.0239	0.000000053	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04424621	chr6:27101941	6	27101941	HIST1H2BJ	South shore	-0.13	0.0239	0.000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25671837	chr6:127513912	6	127513912	RSPO3	Open sea	-0.12	0.0221	0.000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04773818	chr8:31496966	8	31496966	NRG1	Island	0.19	0.0349	0.000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08646313	chr8:98058371	8	98058371	PGCP	Open sea	-0.14	0.0257	0.000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10721220	chr8:29743492	8	29743492	-	Open sea	-0.13	0.0239	0.000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21845457	chr8:65499091	8	65499091	-	North shore	-0.1	0.0184	0.000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06806711	chr11:60223291	11	60223291	MS4A1	Open sea	0.07	0.0129	0.000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25839482	chr15:75931953	15	75931953	IMP3	Island	-0.13	0.0239	0.000000054	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09182189	chr1:1709203	1	1709203	NADK	North shore	-0.07	0.0129	0.000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17264670	chr6:153452732	6	153452732	RGS17	Island	0.18	0.0331	0.000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25302957	chr6:17282284	6	17282284	RBM24	Island	0.13	0.0239	0.000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05012825	chr19:45147078	19	45147078	PVR	Island	0.2	0.0368	0.000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26486070	chr22:25003675	22	25003675	GGT1	Open sea	-0.1	0.0184	0.000000055	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04105282	chr10:99790170	10	99790170	CRTAC1	Island	0.17	0.0313	0.000000056	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20306574	chr14:24601499	14	24601499	FITM1	Island	0.13	0.0239	0.000000056	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07033372	chr20:37353032	20	37353032	SLC32A1	Island	0.22	0.0405	0.000000056	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26994225	chr2:119616769	2	119616769	-	Island	0.11	0.0203	0.000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24049629	chr3:50376475	3	50376475	RASSF1	North shore	-0.19	0.035	0.000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00327072	chr5:172110477	5	172110477	NEURL1B	Island	-0.28	0.0516	0.000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24566400	chr10:95361208	10	95361208	RBP4	Island	0.15	0.0276	0.000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04439241	chr11:45101593	11	45101593	-	Open sea	0.09	0.0166	0.000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02320481	chr13:110438578	13	110438578	IRS2	Island	0.19	0.035	0.000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24089600	chr13:110960177	13	110960177	COL4A1;COL4A2	Island	0.14	0.0258	0.000000057	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12720965	chr1:245397981	1	245397981	KIF26B	Open sea	-0.1	0.0184	0.000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26324366	chr6:99283652	6	99283652	POU3F2	Island	0.09	0.0166	0.000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26953640	chr17:1174473	17	1174473	BHLHA9	Island	0.17	0.0313	0.000000058	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25837803	chr1:186649909	1	186649909	PTGS2	Island	0.17	0.0314	0.000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13267931	chr7:101006308	7	101006308	EMID2	Island	0.17	0.0314	0.000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10928294	chr17:41739326	17	41739326	MEOX1	Open sea	-0.07	0.0129	0.000000059	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17525406	chr1:4715520	1	4715520	AJAP1	Island	0.14	0.0258	0.00000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07571951	chr7:75931608	7	75931608	HSPB1	North shore	0.04	0.0074	0.00000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08668551	chr11:126873181	11	126873181	-	Island	0.16	0.0295	0.00000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16201674	chr13:95364586	13	95364586	SOX21	Island	0.11	0.0203	0.00000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09247392	chr14:94424156	14	94424156	ASB2	Open sea	-0.08	0.0148	0.00000006	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09888330	chr1:156786010	1	156786010	SH2D2A;NTRK1	South shore	-0.05	0.0092	0.000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08247450	chr4:171011099	4	171011099	AADAT	Island	0.13	0.024	0.000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20630655	chr15:75918700	15	75918700	SNUPN	South shore	-0.08	0.0148	0.000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12757310	chr20:32951968	20	32951968	ITCH	Island	0.12	0.0222	0.000000061	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09718582	chr2:240751196	2	240751196	-	Open sea	-0.12	0.0222	0.000000062	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27252776	chr3:124564252	3	124564252	ITGB5	Open sea	-0.11	0.0203	0.000000062	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09423312	chr7:1163549	7	1163549	C7orf50	Open sea	-0.14	0.0259	0.000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02225716	chr8:120220856	8	120220856	MAL2	Island	0.22	0.0407	0.000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20253994	chr11:16628456	11	16628456	-	Island	0.13	0.024	0.000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00716579	chr19:13984990	19	13984990	MIR181C;MIR181D	South shore	-0.12	0.0222	0.000000063	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00549219	chr5:177370476	5	177370476	-	North shore	-0.06	0.0111	0.000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13448753	chr10:25464059	10	25464059	LOC100128811;GPR158	Island	0.16	0.0296	0.000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08173263	chr19:14276911	19	14276911	LPHN1	South shelf	0.11	0.0203	0.000000064	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08924566	chr1:202181869	1	202181869	LGR6	North shore	-0.09	0.0167	0.000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08544331	chr1:25246922	1	25246922	RUNX3	Open sea	-0.11	0.0204	0.000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22079827	chr1:114656043	1	114656043	SYT6	Open sea	0.08	0.0148	0.000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06189394	chr3:66534050	3	66534050	LRIG1	Open sea	-0.1	0.0185	0.000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02172150	chr7:70597774	7	70597774	WBSCR17	Island	0.13	0.0241	0.000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10424892	chr12:9602245	12	9602245	DDX12	South shore	0.16	0.0296	0.000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23721083	chr15:68682927	15	68682927	ITGA11	Open sea	-0.12	0.0222	0.000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02917867	chr19:1265999	19	1265999	-	Island	-0.09	0.0167	0.000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05627639	chr19:34113449	19	34113449	CHST8	Island	0.14	0.0259	0.000000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11816202	chrY:21239332	Y	21239332	TTTY14	Island	0.4	0.0741	0.000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18132076	chr6:1970710	6	1970710	GMDS	Open sea	0.1	0.0185	0.000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25076408	chr6:158733152	6	158733152	TULP4	Open sea	-0.1	0.0185	0.000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21201396	chr11:70665271	11	70665271	SHANK2	North shore	-0.09	0.0167	0.000000066	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23035209	chr5:72795181	5	72795181	BTF3	South shore	-0.1	0.0185	0.000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01439566	chr11:113932189	11	113932189	ZBTB16	Island	0.08	0.0148	0.000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22304262	chr19:47287778	19	47287778	SLC1A5	North shelf	-0.11	0.0204	0.000000067	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05397202	chr1:1245040	1	1245040	PUSL1	Island	-0.07	0.013	0.000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14838433	chr1:55446303	1	55446303	TMEM61	Island	0.12	0.0222	0.000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12761472	chr6:119031922	6	119031922	-	Open sea	-0.11	0.0204	0.000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08928675	chr7:5528044	7	5528044	FBXL18	Island	-0.1	0.0185	0.000000068	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26589669	chr10:106028206	10	106028206	GSTO2	North shore	-0.09	0.0167	0.000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25371036	chr11:94500749	11	94500749	AMOTL1	North shore	-0.08	0.0148	0.000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15415452	chr13:112759355	13	112759355	-	Island	0.15	0.0278	0.000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23848624	chr13:100622582	13	100622582	ZIC5	Island	0.21	0.0389	0.000000069	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01539224	chr14:104639296	14	104639296	KIF26A	Island	-0.11	0.0204	0.00000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08139247	chr14:38725312	14	38725312	CLEC14A	Island	0.18	0.0334	0.00000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02775417	chr19:643457	19	643457	FGF22	Island	-0.3	0.0556	0.00000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08153621	chr19:53561441	19	53561441	-	Island	0.1	0.0185	0.00000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12215340	chr20:4229610	20	4229610	ADRA1D	Island	0.15	0.0278	0.00000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26390598	chr21:41032396	21	41032396	B3GALT5	Open sea	0.18	0.0334	0.00000007	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22786748	chr6:31034042	6	31034042	-	Open sea	-0.09	0.0167	0.000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03084901	chr13:100634630	13	100634630	ZIC2	Island	0.12	0.0223	0.000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01594685	chr16:3115053	16	3115053	IL32	Open sea	-0.08	0.0148	0.000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02482218	chr16:12995568	16	12995568	SHISA9	Island	0.15	0.0278	0.000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08726900	chr16:89550474	16	89550474	ANKRD11	Open sea	0.12	0.0223	0.000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08457011	chr17:2659081	17	2659081	-	Island	0.21	0.039	0.000000071	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09022422	chr3:10857798	3	10857798	SLC6A11	Island	0.18	0.0334	0.000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14943908	chr6:31589196	6	31589196	BAT2	South shore	-0.08	0.0149	0.000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17352276	chr15:66795208	15	66795208	SNORD16;RPL4;SNORD18B	Open sea	-0.09	0.0167	0.000000072	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00458505	chrX:17393449	X	17393449	NHS	Island	0.29	0.0539	0.000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01916333	chr5:121647634	5	121647634	SNCAIP	Island	0.15	0.0279	0.000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05632420	chr7:130793732	7	130793732	MKLN1;FLJ43663	North shore	-0.09	0.0167	0.000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17823346	chr10:80848143	10	80848143	ZMIZ1	Open sea	-0.09	0.0167	0.000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25488288	chr10:735472	10	735472	DIP2C	Island	0.18	0.0334	0.000000073	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08900404	chr7:29605808	7	29605808	PRR15	North shore	-0.18	0.0334	0.000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16567172	chr7:75931606	7	75931606	HSPB1	North shore	0.05	0.0093	0.000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16839083	chr7:193229	7	193229	FAM20C	Island	0.16	0.0297	0.000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00517855	chr8:146016408	8	146016408	RPL8	North shore	-0.06	0.0111	0.000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16856286	chr12:54332992	12	54332992	HOXC13	Island	0.21	0.039	0.000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01567771	chr14:22191382	14	22191382	-	Open sea	-0.09	0.0167	0.000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13855261	chr17:14206572	17	14206572	HS3ST3B1;MGC12916	Island	-0.11	0.0204	0.000000074	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08159291	chr1:4715615	1	4715615	AJAP1	Island	0.14	0.026	0.000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03609960	chr12:99288805	12	99288805	ANKS1B	Island	0.12	0.0223	0.000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16213217	chr13:50074189	13	50074189	PHF11	South shelf	-0.1	0.0186	0.000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19579167	chr18:5543878	18	5543878	EPB41L3	Island	0.19	0.0353	0.000000075	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00602811	chr2:145278564	2	145278564	ZEB2	North shelf	-0.08	0.0149	0.000000076	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09636163	chr2:111829360	2	111829360	ACOXL	Open sea	-0.09	0.0167	0.000000076	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03521812	chr1:192074523	1	192074523	-	Open sea	-0.12	0.0223	0.000000077	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg24735226	chr1:65096537	1	65096537	CACHD1	Open sea	0.14	0.0261	0.000000077	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03499943	chr10:126211704	10	126211704	LHPP	Open sea	-0.21	0.0391	0.000000077	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00582971	chr5:178422128	5	178422128	GRM6	Island	0.23	0.0428	0.000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22418909	chr8:41166738	8	41166738	SFRP1	Island	0.13	0.0242	0.000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14621053	chr10:128077315	10	128077315	ADAM12	Island	0.15	0.0279	0.000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07195577	chr17:27052828	17	27052828	TLCD1	North shore	-0.15	0.0279	0.000000078	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05211057	chr6:70992454	6	70992454	COL9A1	Island	0.16	0.0298	0.000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19053889	chr7:1098703	7	1098703	C7orf50;GPR146	South shore	-0.09	0.0168	0.000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07779120	chr15:99194021	15	99194021	IGF1R	Island	0.25	0.0466	0.000000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03226435	chr1:3058199	1	3058199	PRDM16	North shore	-0.09	0.0168	0.00000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11534240	chr1:183442651	1	183442651	SMG7	South shore	-0.05	0.0093	0.00000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15405439	chr3:96533530	3	96533530	EPHA6	Island	0.12	0.0224	0.00000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15379354	chr4:25032556	4	25032556	LGI2	South shore	0.31	0.0578	0.00000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22747746	chr8:23564193	8	23564193	NKX2-6	Island	0.15	0.0279	0.00000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14557714	chr9:90341385	9	90341385	CTSL1	Island	0.22	0.041	0.00000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06419793	chr19:11376508	19	11376508	-	South shelf	-0.06	0.0112	0.00000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06032349	chr21:40032331	21	40032331	ERG	Island	0.11	0.0205	0.00000008	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18279094	chr1:63790044	1	63790044	FOXD3	Island	0.17	0.0317	0.000000081	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09268963	chr14:64692302	14	64692302	SYNE2	Open sea	-0.08	0.0149	0.000000081	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00116430	chr1:94188268	1	94188268	-	Open sea	-0.1	0.0186	0.000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12810800	chr2:159788345	2	159788345	-	Open sea	-0.08	0.0149	0.000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02105519	chr5:140306205	5	140306205	PCDHA7;PCDHA12;PCDHA6;PCDHAC1;PCDHA10;PCDHA4;PCDHA11;PCDHA8;PCDHA1;PCDHA2;PCDHA9;PCDHA13;PCDHA5;PCDHA3	Island	0.27	0.0503	0.000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03604424	chr5:14171590	5	14171590	TRIO	Open sea	-0.08	0.0149	0.000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10807309	chr6:31761062	6	31761062	VARS	North shelf	0.08	0.0149	0.000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27122536	chr16:86544658	16	86544658	FOXF1	Island	0.12	0.0224	0.000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03568305	chr17:38183559	17	38183559	MED24;SNORD124	Open sea	-0.09	0.0168	0.000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15059065	chr19:17354961	19	17354961	NR2F6	North shore	-0.15	0.028	0.000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14769207	chr21:38071807	21	38071807	SIM2	Island	0.17	0.0317	0.000000082	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04514392	chr3:107086058	3	107086058	-	Open sea	0.13	0.0243	0.000000083	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21884231	chr3:170303721	3	170303721	SLC7A14	Island	0.2	0.0373	0.000000083	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09560590	chr5:143191663	5	143191663	HMHB1	Open sea	0.11	0.0205	0.000000083	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06769918	chr6:13015005	6	13015005	PHACTR1	Island	-0.07	0.0131	0.000000083	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18769303	chrX:151806352	X	151806352	GABRQ	Island	0.15	0.028	0.000000084	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18857467	chr1:32787489	1	32787489	HDAC1	Open sea	-0.1	0.0187	0.000000084	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25963041	chr19:57049777	19	57049777	ZFP28	Island	0.21	0.0392	0.000000084	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22972989	chr7:54614210	7	54614210	VSTM2A	Island	0.18	0.0336	0.000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26170604	chr7:8482614	7	8482614	NXPH1	Island	0.2	0.0373	0.000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00396865	chr9:139620597	9	139620597	SNHG7;SNORA43	North shore	-0.06	0.0112	0.000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13929328	chr10:129535898	10	129535898	FOXI2	Island	0.14	0.0261	0.000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10279487	chr17:76355288	17	76355288	SOCS3	Island	-0.16	0.0299	0.000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09472159	chr19:14693814	19	14693814	CLEC17A	Open sea	0.09	0.0168	0.000000085	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09172850	chr1:191933198	1	191933198	-	Open sea	-0.09	0.0168	0.000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11566172	chr1:159751352	1	159751352	DUSP23	Island	0.07	0.0131	0.000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03698948	chr6:39760092	6	39760092	DAAM2	Island	0.1	0.0187	0.000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg14333542	chr10:75647561	10	75647561	-	Open sea	-0.07	0.0131	0.000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20045492	chr10:46992909	10	46992909	GPRIN2	Island	0.19	0.0355	0.000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25252598	chr12:6641602	12	6641602	-	North shore	-0.08	0.0149	0.000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03721291	chr17:73649149	17	73649149	RECQL5	Open sea	0.04	0.0075	0.000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12856708	chr17:43442340	17	43442340	-	Open sea	-0.08	0.0149	0.000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12699865	chr20:32583031	20	32583031	RALY	South shore	-0.06	0.0112	0.000000086	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19654061	chr2:233243398	2	233243398	ALPP	North shore	-0.1	0.0187	0.000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01598596	chr3:187464648	3	187464648	BCL6	South shelf	-0.12	0.0224	0.000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13751113	chr11:118085214	11	118085214	AMICA1	Open sea	-0.09	0.0168	0.000000087	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11238048	chr6:168720487	6	168720487	DACT2	Island	0.13	0.0243	0.000000088	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03345093	chr13:100634198	13	100634198	ZIC2	Island	0.16	0.0299	0.000000088	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05057720	chr14:38724675	14	38724675	CLEC14A	Island	0.25	0.0467	0.000000088	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15410835	chr8:143125637	8	143125637	-	Open sea	-0.12	0.0224	0.000000089	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg17065712	chr10:80850605	10	80850605	ZMIZ1	Open sea	-0.09	0.0168	0.000000089	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15874092	chr20:59827921	20	59827921	CDH4	Island	0.16	0.0299	0.000000089	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13658542	chr4:187645059	4	187645059	FAT1	Island	0.26	0.0486	0.00000009	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01677601	chr11:12399777	11	12399777	PARVA	Island	0.13	0.0243	0.00000009	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11146034	chr12:96590670	12	96590670	ELK3	South shore	-0.07	0.0131	0.00000009	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04800503	chr17:46648533	17	46648533	HOXB3	Open sea	-0.21	0.0393	0.00000009	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23651812	chr1:1104366	1	1104366	MIR429	South shelf	-0.16	0.0299	0.000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22874893	chr6:17281624	6	17281624	RBM24	Island	0.17	0.0318	0.000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19429281	chr19:53496738	19	53496738	ZNF702P	Island	0.29	0.0543	0.000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23473819	chr19:708670	19	708670	PALM	Island	0.12	0.0225	0.000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27212232	chr20:53091600	20	53091600	DOK5	North shore	-0.07	0.0131	0.000000091	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26376241	chr2:65594021	2	65594021	SPRED2	Open sea	-0.13	0.0243	0.000000092	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00237876	chr17:41924043	17	41924043	CD300LG	Open sea	-0.1	0.0187	0.000000092	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15553397	chr1:76695186	1	76695186	ST6GALNAC3	Open sea	0.06	0.0112	0.000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18450254	chr3:64200005	3	64200005	PRICKLE2	Open sea	0.11	0.0206	0.000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12654519	chr4:148715234	4	148715234	ARHGAP10	Open sea	-0.08	0.015	0.000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22871668	chr6:133562492	6	133562492	EYA4	Island	0.22	0.0412	0.000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06716508	chr7:99816473	7	99816473	GATS;PVRIG	Open sea	-0.09	0.0169	0.000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg11701471	chr8:54164051	8	54164051	OPRK1	Island	0.18	0.0337	0.000000093	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10451760	chrX:136649093	X	136649093	ZIC3	Island	0.15	0.0281	0.000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26234787	chr2:133174042	2	133174042	GPR39	Island	0.13	0.0244	0.000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg02315870	chr7:26236721	7	26236721	HNRNPA2B1	North shelf	-0.07	0.0131	0.000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05053979	chr14:89681043	14	89681043	FOXN3	Open sea	-0.12	0.0225	0.000000094	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10159215	chr1:99470560	1	99470560	LPPR5	Island	0.18	0.0337	0.000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05360477	chr2:12959313	2	12959313	-	Open sea	-0.09	0.0169	0.000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23395310	chr9:139623427	9	139623427	SNHG7	Island	-0.07	0.0131	0.000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg22635096	chr21:46550644	21	46550644	ADARB1	North shelf	0.06	0.0112	0.000000095	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23106251	chrX:144900190	X	144900190	SLITRK2	Island	0.13	0.0244	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg13385220	chr1:202250453	1	202250453	LGR6	Open sea	-0.11	0.0206	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg03450948	chr2:177053274	2	177053274	HOXD1	Island	0.15	0.0281	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg19399165	chr2:27301252	2	27301252	EMILIN1	Open sea	-0.09	0.0169	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21681705	chr2:107506849	2	107506849	-	South shelf	0.12	0.0225	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15593298	chr3:142681996	3	142681996	PAQR9	Island	0.19	0.0356	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16703956	chr5:1446217	5	1446217	SLC6A3	Island	0.15	0.0281	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04791256	chr9:126131309	9	126131309	CRB2	North shore	-0.06	0.0112	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08776660	chr16:1670473	16	1670473	CRAMP1L	Open sea	-0.08	0.015	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04716990	chr20:13976126	20	13976126	MACROD2	Island	0.23	0.0431	0.000000096	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06621863	chrX:83443154	X	83443154	RPS6KA6	Island	0.11	0.0206	0.000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04606861	chr12:132905735	12	132905735	GALNT9	Island	0.11	0.0206	0.000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01105802	chr17:5023696	17	5023696	ZNF232	North shelf	-0.05	0.0094	0.000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg00324097	chr17:75446549	17	75446549	SEPT9	North shore	-0.06	0.0113	0.000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg10064322	chr19:14591203	19	14591203	GIPC1	Island	-0.08	0.015	0.000000097	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07177756	chr1:173836307	1	173836307	SNORD75;SNORD78;ZBTB37;SNORD76;GAS5;SNORD77;SNORD44	North shore	-0.15	0.0281	0.000000098	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21408360	chr1:203493477	1	203493477	-	Open sea	-0.09	0.0169	0.000000098	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08712932	chr6:133562463	6	133562463	EYA4	Island	0.13	0.0244	0.000000099	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg27659049	chr12:115173713	12	115173713	-	Island	0.13	0.0244	0.000000099	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg08152546	chr13:112717207	13	112717207	-	Island	0.11	0.0206	0.000000099	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg20329220	chr15:78286521	15	78286521	LOC91450	Open sea	-0.04	0.0075	0.000000099	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15570293	chr19:2327692	19	2327692	LSM7;SPPL2B	North shore	-0.11	0.0206	0.000000099	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16619425	chr20:59828528	20	59828528	CDH4	Island	0.11	0.0206	0.000000099	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg26954951	chr6:167507568	6	167507568	-	Island	-0.05	0.0094	0.0000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06462796	chr9:79634861	9	79634861	FOXB2	Island	0.08	0.015	0.0000001	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16547579	chr20:4954333	20	4954333	SLC23A2	Open sea	-0.13	0.0255	0.00000034	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg09338136	chr5:344057	5	344057	AHRR	Island	-0.07	0.0141	0.00000065	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23351584	chr11:86512100	11	86512100	PRSS23	South shore	-0.11	0.0223	0.00000079	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01757168	chr3:128215565	3	128215565	-	Island	-0.12	0.0247	0.0000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg12101586	chr15:75019203	15	75019203	CYP1A1	Island	-0.13	0.0273	0.000002	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg15698545	chr11:86383723	11	86383723	ME3	South shore	-0.09	0.019	0.0000023	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg23925513	chr17:6923526	17	6923526	-	North shore	-0.06	0.0128	0.000003	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg07162320	chr1:155295267	1	155295267	RUSC1;C1orf104	Island	-0.08	0.0173	0.0000037	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21570209	chr19:46367987	19	46367987	FOXA3;SYMPK	South shore	-0.13	0.0282	0.0000041	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg25317941	chr2:233351153	2	233351153	ECEL1	Island	0.04	0.0092	0.000013	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg16114213	chr6:33165592	6	33165592	RXRB	North shelf	-0.06	0.0148	0.00005	None	31552803_Dugue-PA_smoking_current_vs_never_smoking