EWAS Catalog β

The MRC-IEU catalog of epigenome-wide association studies

Queries related to 6:15000000-25000000

 

Type ID Results Description
region 6:15000000-25000000 4448 genes:52  CpG sites:2429 
gene JARID2 519 location:6:15246527-15522252  sites:190 
gene ATXN1 321 location:6:16299343-16761722  sites:194 
gene CDKAL1 202 location:6:20534688-21232635  sites:145 
gene KIF13A 183 location:6:17759414-17987854  sites:70 
gene RBM24 157 location:6:17281577-17294106  sites:35 
gene FAM65B 132 location:6:24797601-25042238  sites:101 
gene DTNBP1 112 location:6:15523032-15663289  sites:65 
gene E2F3 85 location:6:20402398-20493941  sites:56 
gene GMPR 81 location:6:16238811-16295780  sites:36 
gene CAP2 79 location:6:17393447-17558023  sites:32 
gene ID4 68 location:6:19837617-19840915  sites:15 
gene NHLRC1 67 location:6:18120718-18122851  sites:16 
gene NUP153 63 location:6:17615269-17706656  sites:31 
gene MYLIP 62 location:6:16129356-16148479  sites:23 
gene NRSN1 58 location:6:24126350-24155128  sites:25 
gene SOX4 49 location:6:21593972-21598847  sites:23 
gene GPLD1 48 location:6:24424793-24495433  sites:27 
gene KIAA0319 46 location:6:24544332-24646383  sites:38 
gene RNF144B 43 location:6:18368779-18469105  sites:30 
gene FAM8A1 42 location:6:17600586-17611950  sites:16 
gene ALDH5A1 40 location:6:24495080-24537435  sites:32 
gene DCDC2 38 location:6:24171984-24358280  sites:37 
gene DEK 36 location:6:18224099-18265054  sites:23 
gene MRS2 34 location:6:24403153-24425810  sites:22 
gene MBOAT1 29 location:6:20100935-20212670  sites:29 
gene HDGFL1 27 location:6:22569678-22571892  sites:16 
gene PRL 25 location:6:22287480-22297730  sites:13 
gene C6ORF62 20 location:6:24705089-24721064  sites:16 
gene GMNN 19 location:6:24775159-24786327  sites:18 
gene KDM1B 18 location:6:18155560-18224084  sites:14 
gene ACOT13 17 location:6:24667263-24705293  sites:8 
gene TPMT 4 location:6:18128542-18155305  sites:10 
gene CASC15 2 location:6:21665003-22214734  sites:62 
study 30602389_battram-t_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells 328363 author:Battram T  PMID:30602389   trait:Tissue  tissue:Buccal cells and peripheral blood mononuclear cells  array:Illumina HumanMethylation450  n:215 
study 33450751_mulder-rh_age_model_1_with_age_as_a_fixed_effect 305623 author:Mulder RH  PMID:33450751   trait:age  tissue:Whole blood  array:Illumina HumanMethylation450  n:2338 
study 33450751_mulder-rh_age_model_1_with_age_as_a_random_effect 178952 author:Mulder RH  PMID:33450751   trait:age  tissue:Whole blood  array:Illumina HumanMethylation450  n:2338 
study 33450751_mulder-rh_age_model_2_at_9y_with_age_as_a_random_effect 86083 author:Mulder RH  PMID:33450751   trait:age  tissue:Whole blood  array:Illumina HumanMethylation450  n:2338 
study 33450751_mulder-rh_age_model_2_at_6y_with_age_as_a_fixed_effect 60583 author:Mulder RH  PMID:33450751   trait:age  tissue:Whole blood  array:Illumina HumanMethylation450  n:2338 
study 33450751_mulder-rh_age_model_2_at_9y_with_age_as_a_fixed_effect 58220 author:Mulder RH  PMID:33450751   trait:age  tissue:Whole blood  array:Illumina HumanMethylation450  n:2338 
study 23334450_rheumatoid_arthritis 51476 author:Liu Y  PMID:23334450   trait:Rheumatoid arthritis  tissue:Whole blood  array:Illumina HumanMethylation450  n:691 
study 33450751_mulder-rh_sex_discovery 50532 author:Mulder RH  PMID:33450751   trait:sex  tissue:Whole blood  array:Illumina HumanMethylation450  n:2338 
study 27105112_hiv_infection_discovery 50327 author:Gross AM  PMID:27105112   trait:HIV infection  tissue:Whole blood  array:Illumina HumanMethylation450  n:181 
study 23526956_clear_cell_renal_carcinoma 35550 author:Wozniak MB  PMID:23526956   trait:Clear cell renal carcinoma  tissue:Clear cell renal carcinoma tumour cells, adjacent healthy cells  array:Illumina HumanMethylation450  n:129 
study 25282492_fetal_vs_adult_liver 28901 author:Bonder MJ  PMID:25282492   trait:Fetal vs adult liver  tissue:Liver  array:Illumina HumanMethylation450  n:195 
study 25650246_gestational_age 28718 author:Spiers H  PMID:25650246   trait:Gestational age  tissue:Fetal brain  array:Illumina HumanMethylation450  n:179 
study 27717397_gestational_age_last_menstrual_periodestimated_gestational_age 22743 author:Bohlin J  PMID:27717397   trait:Gestational age  tissue:Cord blood  array:Illumina HumanMethylation450  n:1068 
study 26500701_sex_kora_f4 21778 author:Singmann P  PMID:26500701   trait:Sex  tissue:Whole blood  array:Illumina HumanMethylation450  n:1799 
study 33564054_kashima-k_gestational_age 20297 author:Kashima K  PMID:33564054   trait:gestational age  tissue:Cord blood  array:Illumina HumanMethylation450  n:110 
study 31536415_sikdar-s_smoking_random_effects_meta-analysis 17438 author:Sikdar S  PMID:31536415   trait:Smoking  tissue:Whole blood, CD4+ T cells, CD14+ monocytes  array:Illumina HumanMethylation450  n:15907 
study 27717397_gestational_age_ultrasoundestimated_gestational_age 14501 author:Bohlin J  PMID:27717397   trait:Gestational age  tissue:Cord blood  array:Illumina HumanMethylation450  n:1068 
study 28056824_age_4_vs_age_0 14150 author:Xu CJ  PMID:28056824   trait:Age 4 vs age 0  tissue:Whole blood, cord blood  array:Illumina HumanMethylation450  n:269 
study 26857698_primary_sjogrens_syndrome_whole_blood 11785 author:Imgenberg-Kreuz J  PMID:26857698   trait:Primary Sjogrens syndrome  tissue:Whole blood  array:Illumina HumanMethylation450  n:500 
study 24500968_pancreatic_ductal_adenocarcinoma 11634 author:Nones K  PMID:24500968   trait:Pancreatic ductal adenocarcinoma  tissue:Pancreatic ductal adenocarcinoma, adjacent nontransformed pancreata  array:Illumina HumanMethylation450  n:196 
study 27105112_hiv_infection_neutrophils 10725 author:Gross AM  PMID:27105112   trait:HIV infection  tissue:Neutrophils  array:Illumina HumanMethylation450  n:60 
study 23177740_battram-t_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 10541 author:Battram T  PMID:23177740   trait:Age  tissue:Whole blood  array:Illumina HumanMethylation450  n:656 
study 27651444_smoking_current_vs_never_smoking 9159 author:Joehanes R  PMID:27651444   trait:Smoking  tissue:CD4+ T cells, monocytes  array:Illumina HumanMethylation450  n:9389 
study 29016858_sharp-gc_maternal_body_mass_index_meta-analysis 9044 author:Sharp GC  PMID:29016858   trait:Maternal body mass index  tissue:Cord blood  array:Illumina HumanMethylation450  n:7523 
study 29410382_lichtenfels-aj_nitrogen_dioxide_exposure 9018 author:Lichtenfels AJ  PMID:29410382   trait:Nitrogen dioxide exposure  tissue:Whole blood  array:Illumina HumanMethylation450  n:1656 
study 32453742_natrii-h_papuan_ancestry 8796 author:NatriI H  PMID:32453742   trait:Papuan ancestry  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:116 
study 25888029_ageing 8540 author:Marttila S  PMID:25888029   trait:Ageing  tissue:Whole blood  array:Illumina HumanMethylation450  n:143 
study 31789449_dugue-p-a_alcohol_consumption_previous_week_consumption_discovery 6729 author:Dugue P-A  PMID:31789449   trait:Alcohol consumption  tissue:Whole blood  array:Illumina HumanMethylation450  n:5606 
study 27105112_hiv_infection_cd4_tcells 6454 author:Gross AM  PMID:27105112   trait:HIV infection  tissue:CD4+ T-cells  array:Illumina HumanMethylation450  n:60 
study 33450751_mulder-rh_age_sex_discovery 6014 author:Mulder RH  PMID:33450751   trait:age*sex  tissue:Whole blood  array:Illumina HumanMethylation450  n:2338 
study 27886173_battram-t_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 5414 author:Battram T  PMID:27886173   trait:Crohn's disease  tissue:Whole blood  array:Illumina HumanMethylation450  n:161 
study 28811542_age 5168 author:Li S  PMID:28811542   trait:Age  tissue:Whole blood  array:Illumina HumanMethylation450  n:1366 
study 26500701_sex_kora_f3 5041 author:Singmann P  PMID:26500701   trait:Sex  tissue:Whole blood  array:Illumina HumanMethylation450  n:500 
study 30966880_hannon-e_gestational_age 4299 author:Hannon E  PMID:30966880   trait:gestational age  tissue:Whole blood  array:Illumina HumanMethylation450  n:1316 
study 33279932_li-m_schizophrenia_main 4277 author:Li M  PMID:33279932   trait:Schizophrenia  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:999 
study 33279932_li-m_schizophrenia_adjusted_for_cell_composition 4277 author:Li M  PMID:33279932   trait:Schizophrenia  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:999 
study 31015461_kupers-l_birthweight_meta_analysis_all_ancestries 4170 author:Kupers L  PMID:31015461   trait:Birthweight  tissue:Cord blood  array:Illumina HumanMethylation450  n:8825 
study 29016858_sharp-gc_maternal_overweight_obesity_meta-analysis 4037 author:Sharp GC  PMID:29016858   trait:Maternal overweight/obesity  tissue:Cord blood  array:Illumina HumanMethylation450  n:7523 
study 27886173_battram-t_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 3632 author:Battram T  PMID:27886173   trait:Inflammatory bowel disease  tissue:Whole blood  array:Illumina HumanMethylation450  n:240 
study 27886173_battram-t_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 3406 author:Battram T  PMID:27886173   trait:Ulcerative colitis  tissue:Whole blood  array:Illumina HumanMethylation450  n:163 
study 33593402_christiansen-c_smoking_current_vs_never_smoking_meta-analysis_in_european_samples 3348 author:Christiansen C  PMID:33593402   trait:Smoking  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:912 
study 31789449_dugue-p-a_alcohol_consumption_lifetime_consumption_discovery 3192 author:Dugue P-A  PMID:31789449   trait:Alcohol consumption  tissue:Whole blood  array:Illumina HumanMethylation450  n:5606 
study 31536415_sikdar-s_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis 3096 author:Sikdar S  PMID:31536415   trait:Prenatal smoke exposure  tissue:Cord blood, whole blood  array:Illumina HumanMethylation450  n:5648 
study 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns 3094 author:Joubert BR  PMID:27040690   trait:Maternal smoking in pregnancy  tissue:Cord blood  array:Illumina HumanMethylation450  n:5647 
study 31789449_dugue-p-a_alcohol_consumption_previous_decade_consumption_discovery 2941 author:Dugue P-A  PMID:31789449   trait:Alcohol consumption  tissue:Whole blood  array:Illumina HumanMethylation450  n:5606 
study 23332324_child_abuse 2856 author:Yang BZ  PMID:23332324   trait:Child abuse  tissue:Saliva  array:Illumina HumanMethylation450  n:192 
study 27843151_alcohol_consumption_per_day_european_ancestry 2626 author:Liu C  PMID:27843151   trait:Alcohol consumption per day  tissue:Whole blood  array:Illumina HumanMethylation450  n:9643 
study 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts 2620 author:Joubert BR  PMID:27040690   trait:Maternal smoking in pregnancy  tissue:Cord blood  array:Illumina HumanMethylation450  n:5647 
study 31230546_kazmi-n_preeclampsia_meta_analysis_unadjusted_model 2581 author:Kazmi N  PMID:31230546   trait:Preeclampsia  tissue:Cord blood  array:Illumina HumanMethylation450  n:3460 
study 25404168_age_t_cells 2570 author:Reynolds LM  PMID:25404168   trait:Age  tissue:T cells  array:Illumina HumanMethylation450  n:227 
study 33257653_zhang-l_alzheimers_disease_braak_stage_meta-analysis 2304 author:Zhang L  PMID:33257653   trait:alzheimers disease braak stage  tissue:Prefrontal cortex  array:Illumina HumanMethylation450  n:1030 
study 27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns 2187 author:Joubert BR  PMID:27040690   trait:Maternal smoking in pregnancy  tissue:Cord blood  array:Illumina HumanMethylation450  n:6685 
study 31230546_kazmi-n_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model 2161 author:Kazmi N  PMID:31230546   trait:Hypertensive disorders of pregnancy  tissue:Cord blood  array:Illumina HumanMethylation450  n:5242 
study 26500701_sex_metaanalysis 1881 author:Singmann P  PMID:26500701   trait:Sex  tissue:Whole blood  array:Illumina HumanMethylation450  n:1999 
study 31552803_dugue-pa_smoking_current_vs_never_smoking 1862 author:Dugue PA  PMID:31552803   trait:Smoking  tissue:Whole blood  array:Illumina HumanMethylation450  n:1851 
study 25404168_age_monocytes 1703 author:Reynolds LM  PMID:25404168   trait:Age  tissue:Monocytes  array:Illumina HumanMethylation450  n:1264 
study 25249537_sex_discovery 1687 author:Shah S  PMID:25249537   trait:Sex  tissue:Whole blood  array:Illumina HumanMethylation450  n:815 
study 25249537_sex_replication 1687 author:Shah S  PMID:25249537   trait:Sex  tissue:Whole blood  array:Illumina HumanMethylation450  n:445 
study 25282492_battram-t_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse61278__compared_fetal_liver_tissue_to_adult_liver_tissue_of_different_individuals 1622 author:Battram T  PMID:25282492   trait:Age  tissue:Fetal liver, adult liver  array:Illumina HumanMethylation450  n:110 
study 26553366_sex 1341 author:Yousefi P  PMID:26553366   trait:Sex  tissue:Cord Blood  array:Illumina HumanMethylation450  n:111 
study 30264654_wang-y_aging 1316 author:Wang Y  PMID:30264654   trait:Aging  tissue:Whole blood  array:Illumina HumanMethylation450  n:1011 
study 33184255_neumann-a_adhd_at_birth 1271 author:Neumann A  PMID:33184255   trait:ADHD  tissue:Cord Blood  array:Illumina HumanMethylation450  n:2477 
study 31426852_tajuddin-sm_age_in_african_american_individuals 1254 author:Tajuddin SM  PMID:31426852   trait:Age  tissue:Whole Blood  array:Illumina HumanMethylationEPIC  n:237 
study 25855720_maternal_underweight_birth 1225 author:Sharp GC  PMID:25855720   trait:Maternal underweight  tissue:Cord blood  array:Illumina HumanMethylation450  n:601 
study 27572077_schizophrenia_phase_1 1223 author:Hannon E  PMID:27572077   trait:Schizophrenia  tissue:Whole blood  array:Illumina HumanMethylation450  n:675 
study 30779925_somineni-h_crohn_s_disease 1189 author:Somineni H  PMID:30779925   trait:Crohn's disease  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:238 
study 28785368_attention_deficit_hyperactivity_disorder_longterm_prenatal_exposure_to_paracetamol_versus_controls 1146 author:Gervin K  PMID:28785368   trait:Attention deficit hyperactivity disorder  tissue:Cord blood  array:Illumina HumanMethylation450  n:115 
study 30736859_lund-jb_mortality_cox_regression 1145 author:Lund JB  PMID:30736859   trait:Mortality  tissue:Whole blood  array:Illumina HumanMethylation450  n:1425 
study 26731791_air_pollution_exposure_28day_trailing_average_particle_matter_concentration 1112 author:Panni T  PMID:26731791   trait:Air pollution exposure  tissue:Whole blood  array:Illumina HumanMethylation450  n:2956 
study 33450751_mulder-rh_age_model_2_at_6y_with_age_as_a_random_effect 1091 author:Mulder RH  PMID:33450751   trait:age  tissue:Whole blood  array:Illumina HumanMethylation450  n:2338 
study 28225026_tobacco_smoking 1062 author:Chatziioannou A  PMID:28225026   trait:Tobacco smoking  tissue:Whole blood  array:Illumina HumanMethylation450  n:454 
study 28603561_cleft_palate_vs_cleft_lip 1056 author:Sharp GC  PMID:28603561   trait:Cleft palate vs cleft lip  tissue:Whole blood  array:Illumina HumanMethylation450  n:98 
study 33646943_hannon-e_schizophrenia_random_effects_meta-analysis 1048 author:Hannon E  PMID:33646943   trait:schizophrenia  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:3264 
study 33646943_hannon-e_schizophrenia_fixed_effects_meta-analysis 1048 author:Hannon E  PMID:33646943   trait:schizophrenia  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:3264 
study 30779925_somineni-h_crohn_s_disease_inflammatory_crohn_s_disease 1000 author:Somineni H  PMID:30779925   trait:Crohn's disease  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:224 
study 23691101_smoking_current_vs_never_smoking_discovery 972 author:Zeilinger S  PMID:23691101   trait:Smoking  tissue:Whole blood  array:Illumina HumanMethylation450  n:1011 
study 27843151_alcohol_consumption_per_day_african_ancestry 942 author:Liu C  PMID:27843151   trait:Alcohol consumption per day  tissue:Whole blood  array:Illumina HumanMethylation450  n:2423 
study 28785368_attention_deficit_hyperactivity_disorder_longterm_prenatal_exposure_to_paracetamol_versus_sporadic_prenatal_exposure_to_paracetamol 922 author:Gervin K  PMID:28785368   trait:Attention deficit hyperactivity disorder  tissue:Cord blood  array:Illumina HumanMethylation450  n:96 
study 31230546_kazmi-n_hypertensive_disorders_of_pregnancy_meta_analysis_adjusted_model 920 author:Kazmi N  PMID:31230546   trait:Hypertensive disorders of pregnancy  tissue:Cord blood  array:Illumina HumanMethylation450  n:5242 
study 23334450_battram-t_rheumatoid_arthritis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse42861 817 author:Battram T  PMID:23334450   trait:Rheumatoid arthritis  tissue:Whole blood  array:Illumina HumanMethylation450  n:689 
study 28693600_age 787 author:Johnson KC  PMID:28693600   trait:Age  tissue:Breast  array:Illumina HumanMethylation450  n:100 
study 26864933_smoking_current_vs_never_smoking 748 author:Ambatipudi S  PMID:26864933   trait:Smoking  tissue:Whole blood  array:Illumina HumanMethylation450  n:721 
study 29383109_battram-t_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse101961 717 author:Battram T  PMID:29383109   trait:Age  tissue:Breast  array:Illumina HumanMethylation450  n:121 
study 31910897_cronjã©-ht_alcohol_consumption 710 author:Cronje HT  PMID:31910897   trait:Alcohol consumption  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:108 
study 30343628_carmona-jj_lung_function_decline_discovery__fvc__lung_function_decline_in_this_paper_is_defined_as_a_decrease_in_fvc_between_visits_ 685 author:Carmona JJ  PMID:30343628   trait:Lung function decline  tissue:Whole blood  array:Illumina HumanMethylation450  n:633 
study 31789449_dugue-p-a_alcohol_consumption_replication 666 author:Dugue P-A  PMID:31789449   trait:Alcohol consumption  tissue:Whole blood  array:Illumina HumanMethylation450  n:5704 
study 30045751_battram-t_alzheimer_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse66351 653 author:Battram T  PMID:30045751   trait:Alzheimer's disease  tissue:Brain  array:Illumina HumanMethylation450  n:190 
study 27651444_smoking_former_vs_never_smoking 648 author:Joehanes R  PMID:27651444   trait:Smoking  tissue:CD4+ T cells, monocytes  array:Illumina HumanMethylation450  n:13474 
study 24603599_battram-t_progressive_supranuclear_palsy_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53740 582 author:Battram T  PMID:24603599   trait:Progressive supranuclear palsy  tissue:Whole blood  array:Illumina HumanMethylation450  n:236 
study 28558807_utero_arsenic_exposure_discovery 579 author:Kaushal A  PMID:28558807   trait:Utero arsenic exposure  tissue:Cord blood  array:Illumina HumanMethylation450  n:64 
study 27843151_alcohol_consumption_per_day_cd14_monocytes 566 author:Liu C  PMID:27843151   trait:Alcohol consumption per day  tissue:CD14+ monocytes  array:Illumina HumanMethylation450  n:1251 
study 30291105_battram-t_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse113904 532 author:Battram T  PMID:30291105   trait:Age  tissue:Colon, rectum  array:Illumina HumanMethylation450  n:232 
study 25650246_sex 521 author:Spiers H  PMID:25650246   trait:Sex  tissue:Fetal brain  array:Illumina HumanMethylation450  n:179 
study 30989176_xu-z_breast_cancer_case_vs_control_discovery 510 author:Xu Z  PMID:30989176   trait:breast cancer  tissue:Whole blood  array:Illumina HumanMethylation450  n:2443 
study 32202197_soriano-tarraga-c_ischaemic_stroke 500 author:Soriano-Tarraga C  PMID:32202197   trait:Ischaemic stroke  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:401 
study 27358653_fetal_alcohol_spectrum_disorder 499 author:Portales-Casamar E  PMID:27358653   trait:Fetal alcohol spectrum disorder  tissue:Buccal  array:Illumina HumanMethylation450  n:206 
study 33593402_christiansen-c_smoking_current_vs_never_smoking_meta-analysis_in_trans-ethnic_samples 486 author:Christiansen C  PMID:33593402   trait:Smoking  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:3425 
study 32202197_soriano-tarraga-c_ischaemic_stroke_meta_analysis 474 author:Soriano-Tarraga C  PMID:32202197   trait:Ischaemic stroke  tissue:Whole blood  array:Illumina HumanMethylationEPIC  n:793 
study 31197173_liu-j_fasting_glucose_base_plus_bmi 465 author:Liu J  PMID:31197173   trait:fasting glucose  tissue:whole blood  array:Illumina HumanMethylation450  n:4808 

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